Group leader

ALSOVA Group leader

Anne Maria Koivisto
Chief Neurologist Consultant
MD, PhD, Special Competence in Medical Education

ALSOVA group leader outside in Kuopio, Finland.

Department of Neurology
Visiting address:
Building 4, 5th floor
Kuopio University Hospital
Kuopio, Finland
+358-(0)44-717 5629 (mobile)
+358-(0)44- 7173029 (office)
+358-(0)17-172 305 (fax)

anne.koivisto (at)


  • Alzheimer’s disease, Normal Pressure Hydrocephalus and other memory disorders:
    • Early diagnosis, differential diagnostics, disease progression, therapy, genetics, health economics, quality of life research, care
  • Treatment of headaches
  • Improvement of medical education

in University of Eastern Finland (UEF) and Kuopio University Hospital (KUH)

  • Professor  in Neurology, Institute of Clinical Medicine, UEF
  • Chief Neurologist Consultant, NeuroCenter, Neurology, KUH
  • Member, Executive Board, NeuroCenter, KUH
  • Chair
    • Regional Group of Experts to Improve Treatment Chains for Persons with Memory Disorders, KUH /  County of North Savo, Finland
    • Keystone Lecturers, Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, UEF
    • Study Program Coordinators for Year 4 Medical Students, Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, UEF
  • Chair/Coordinator, Committee to design and found the KUH Driving Assessment Polyclinic,  KUH
  • Group Leader
    • PI, ALSOVA – Study, UEF
    • PI, BEGAD – Study, UEF and KUH
  • Senior Researcher
    • NPH and Early AD studies, UEF and KUH, Finland
    • Alzheimer Clinical Studies and Genetics, UEF
    • APOLLO – Study, UEF and KUH
    • Obstructive Sleep Apnea and brain study, UEF and KUH
    • Medicine use in Parkinson disease, Pharmacy and Pharmaceutical Sciences, CMUS, Monash University, Melbourne, Australia


  • Chair, Special Competence in Memory Disorders – Finnish Medical Association Committee
  • Board member, The Association for Medical Education in Finland, – Finnish Medical Association Committee
  • Committee member, Neurology Trust Committee, Finnish Brain Society (Suomen Aivosäätiö)
  • Board deputy member, The Alzheimer Research Society , Finland
  • Deputy Chair, Savilahti Neurological Society (SNS), Kuopio, Finland


  • 14 PhD students
    • 6 accepted theses
    • 8 ongoing theses
  • 3 post-doctoral students
    • 1  achieved  associate professorship
  • several Master Degree theses under supervision


Professor Koivisto has collaborated and is still collaborating with several national and international research groups (since 1997) while working as investigator in multicenter clinical trials (e.g. Exelon, Aricept, Galantamine, Memantine studies) and as researcher in scientific studies.


Leinonen, V Junkkari A, Rauramaa T, Jääskeläinen JE, Vanninen R, Savolainen S, Hiltunen M, Remes AM and Koivisto AM. Normal pressure hydrocephalus (NPH) – clinical characteristics, diagnosis and treatment. Duodecim, 2019;135(3):265-73. (In Finnish, Abstract in English)

Peloso GM, van der Lee SJ; International Genomics of Alzheimer’s Project (IGAP), Destefano AL, Seshardi S. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer’s disease. Alzheimers Dement (Amst). 2018 Sep 22;10:595-598. doi: 10.1016/j.dadm.2018.08.008. eCollection 2018. PubMed PMID: 30422133; PubMed Central PMCID: PMC6215982.

Katisko K, Kokkonen N, Krüger J, Hartikainen P, Koivisto AM, Helisalmi S, Korhonen VE, Kokki M, Tuusa J, Herukka SK, Solje E, Haapasalo A, Tasanen K, Remes AM. The Association Between Frontotemporal Lobar Degeneration and Bullous Pemphigoid. J Alzheimers Dis. 2018;66(2):743-750.

Koivisto AM, Teemu Paajanen T, Juha Rinne J, Hokkanen L, Vanninen R, Herukka S-K, Lötjönen J and Hallikainen M. Early recognition of Alzheimer’s disease. Duodecim 2018;134(24):2519-28 (In Finnish, Abstract in English)

Välimäki T, Gilmartin-Thomas JF, Bell JS, Selander T, Koivisto AM. Longitudinal study of medication use in caregivers of people with Alzheimer’s disease – Kuopio ALSOVA study. Dementia (London). 2018 Oct 2:1471301218802675. doi: 10.1177/1471301218802675. [Epub ahead of print] PubMed PMID: 30278783.

Leal NS, Dentoni G, Schreiner B, Kämäräinen OP, Partanen N, Herukka SK, Koivisto AM, Hiltunen M, Rauramaa T, Leinonen V, Ankarcrona M. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients. Acta Neuropathol Commun. 2018  Oct 1;6(1):102. doi: 10.1186/s40478-018-0605-2. PubMed PMID: 30270816; PubMed Central PMCID: PMC6166280.

Katisko K, Solje E, Koivisto AM, Krüger J, Kinnunen T, Hartikainen P, Helisalmi S, Korhonen V, Herukka SK, Haapasalo A, Remes AM. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers. J Neuroimmunol. 2018 Aug  15;321:29-35. doi: 10.1016/j.jneuroim.2018.05.011. Epub 2018 May 22. PubMed PMID: 29957385.

Saari T, Hallikainen I, Hänninen T, Räty H, Koivisto A. Relationships between Cognition and Activities of Daily Living in Alzheimer’s Disease During a 5-Year Follow-Up: ALSOVA Study. J Alzheimers Dis. 2018;64(1):269-279. doi: 10.3233/JAD-171059. PubMed PMID: 29889073.

Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto AM, Jääskeläinen JE, Hiltunen M, Herukka SK, Blennow K, Zetterberg H, Jokinen P, Rokka J, Helin S, Haaparanta-Solin M, Solin O, Okamura N, Kolb HC, Rinne JO. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies. J Alzheimers Dis. 2018;64(1):171-179. doi: 10.3233/JAD-180071. PubMed PMID: 29865068.

Hallikainen I, Koivisto AM, Välimäki T. The influence of the individual neuropsychiatric symptoms of people with Alzheimer disease on family caregiver distress-A longitudinal ALSOVA study. Int J Geriatr Psychiatry. 2018 May 30. doi: 10.1002/gps.4911. [Epub ahead of print] PubMed PMID: 29851148.

Vanhala V, Junkkari A, Korhonen VE, Kurki MI, Hiltunen M, Rauramaa T, Nerg O, Koivisto AM, Remes AM, Perälä J, Suvisaari J, Lehto SM, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus. Neurosurgery. 2018 May 8. doi: 10.1093/neuros/nyy147.[Epub ahead of print] PubMed PMID: 29741669.

Katisko K, Haapasalo A, Koivisto A, Krüger J, Hartikainen P, Korhonen V, Helisalmi S, Herukka SK, Remes AM, Solje E. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration. J Alzheimers Dis. 2018;62(2):789-794. doi: 10.3233/JAD-170854. PubMed PMID: 29480183.

Haapalinna F, Kokki M, Jääskeläinen O, Hallikainen M, Helisalmi S, Koivisto A, Kokki H, Paajanen T, Penttinen J, Pikkarainen M, Rautiainen M, Soininen H, Solje E, Remes AM, Herukka SK. Subtle Cognitive Impairment and Alzheimer’s Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects. J Alzheimers Dis. 2018;62(1):165-174. doi: 10.3233/JAD-170534. PubMed PMID: 29439329.

Hallikainen I, Hongisto K, Välimäki T, Hänninen T, Martikainen J, Koivisto AM. The Progression of Neuropsychiatric Symptoms in Alzheimer’s Disease During a Five-Year Follow-Up: Kuopio ALSOVA Study. J Alzheimers Dis. 2018;61(4):1367-1376. doi: 10.3233/JAD-170697. PubMed PMID: 29376861.

Pyykkö OT, Nerg O, Niskasaari HM, Niskasaari T, Koivisto AM, Hiltunen M, Pihlajamäki J, Rauramaa T, Kojoukhova M, Alafuzoff I, Soininen H, Jääskeläinen JE, Leinonen V. Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus. World Neurosurg. 2018 Apr;112:e624-e631. doi: 10.1016/j.wneu.2018.01.107. Epub 2018 Jan 31. PubMed PMID: 29374607.

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. Alzheimer’s Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus. J Alzheimers Dis. 2017;60(3):1077-1085. doi: 10.3233/JAD-170583. PubMed PMID: 28984604.

Junkkari A, Roine RP, Luikku A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Häyrinen A, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Why Does the Health-Related Quality of Life in Idiopathic Normal-Pressure Hydrocephalus Failo Improve Despite the Favorable Clinical Outcome? World Neurosurg. 2017 Dec;108:356-366. Epub 2017 Sep 5. IF 2.592.

Sims R, van der Lee SJ, Naj AC, Bellenguez C…Koivisto AM…Schellenberg GD with researchers from 280 universities . Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. Nat Genet. 2017 Jul 17. doi: 10.1038/ng.3916. [Epub ahead of print] PubMed PMID: 28714976.

Törmälehto S., Martikainen J., Bell S.J. and Koivisto AM. Use of psychotropic medications in relation to neuropsychiatric symptoms, cognition and functional performance in Alzheimer’s disease over a three-year period: Kuopio ALSOVA study. Int Psychogeriatr. 2017 Jun 19:1-11.