{"id":1438,"date":"2021-09-13T15:42:44","date_gmt":"2021-09-13T12:42:44","guid":{"rendered":"https:\/\/sites.uef.fi\/biophysics\/?page_id=1438"},"modified":"2025-08-20T16:17:35","modified_gmt":"2025-08-20T13:17:35","slug":"ramis-group","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/","title":{"rendered":"Cell and Tissue Biomechanics"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Principal investigators<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/rami.korhonen\/\">Rami K. Korhonen<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/juha.toyras\/\/\">Juha T\u00f6yr\u00e4s<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/petri.tanska\/\">Petri Tanska<\/a><\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Senior researchers &amp; postdocs<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/lauri.stenroth\/\">Lauri Stenroth<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/aapo.ristaniemi\/\">Aapo Ristaniemi<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/amir.esrafilian\/\">Amir Esrafilian<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/atte.eskelinen\">Atte Eskelinen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/sana.jahangir\">Sana Jahangir<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/adam.kositsky\/\">Adam Kositsky<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/joonas.kosonen\/\">Joonas Kosonen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/alexander.paz-carvajal\/\">Alexander Paz Carvajal<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Doctoral researchers<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/aya.abdelsalam\/\">Aya Abdelsalam<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/will.bosch-vuononen\/\">Will Lumi Bosch-Vuononen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/sanna.hakonen\/\">Sanna Hakonen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/moustafa.hamada\/\">Moustafa Hamada<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/ellen.hellman\/\">Ellen Hellman<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/rasmus.hiltunen\/\">Rasmus Hiltunen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/katja.honkapaa\/\">Katja Honkap\u00e4\u00e4<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/fatemeh.jalali\/\">Fatemeh Jalali<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/mahan.nematollahi-sanij\/\">Mahan Nematollahi Sanij<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/mikko.nissinen-2\">Mikko Nissinen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/joose.peitola\/\">Joose Peitola<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/uefconnect.uef.fi\/en\/person\/juuso.tuppurainen\/\">Juuso Tuppurainen<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Collaborators<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/be.mit.edu\/directory\/alan-j-grodzinsky\">Professor Alan J. Grodzinsky<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/experts.griffith.edu.au\/18616-david-lloyd\">Professor David G. Lloyd<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.oulu.fi\/university\/researcher\/simo-saarakkala\">Professor Simo Saarakkala<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/portal.research.lu.se\/en\/persons\/hanna-isaksson\">Professor Hanna Isaksson<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/vbn.aau.dk\/en\/persons\/103093\">Professor Michael S. Andersen<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.kuleuven.be\/wieiswie\/en\/person\/00015567\">Professor Ilse Jonkers<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Overview<\/h4>\n\n\n\n<p>Chondrocytes respond differently to varying loading conditions in articular cartilage and their deformations are thought to be related to tissue biosynthesis. Cell deformation behavior in human joints is affected by the applied loading and properties of the cartilage tissue surrounding cells. Altered loading and material properties of the tissue affects cell responses, cartilage synthesis and degradation, and consequently the progression of osteoarthritis. Currently there are no tool to quantitatively evaluate how osteoarthritis progresses in a patient, thus, the prevention of the disease is extremely challenging.<\/p>\n\n\n\n<p>Objectives of our research are to characterize biological materials (primarily articular cartilage) in tissue and cellular level and their behavior and responses under loading, thus, to provide insight into the mechanisms behind osteoarthritis. We also developed state-of-the art models of cartilage and chondrocytes embedded in cartilage matrix for the estimation of the effect of changed loading and cartilage structure on cell deformations (e.g. in disease). In order to quantify tissue and cell responses in human joints, we develop <strong>multi-scale computational models<\/strong> where joint level forces are used as an input to analyze tissue and cell responses. Ultimately these studies aim at patient-specific estimation of joint mechanics, in which imaging and sophisticated computational modeling are combined to estimate stresses, strains, failure sites and progression of osteoarthritis in human joints.<\/p>\n\n\n\n<p>The main methods are macro-, micro- and nano- level mechanical testing, computational modeling and different imaging modalities in different length scales. This is very multidisciplinary research area (e.g. biomechanics, bioengineering, cell biology, public health science). Several national research groups are involved in this research and an active international collaboration and mobility exist within this research area.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Methods<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/sites.uef.fi\/biophysics\/biomechanics-and-modeling\/\">Biomechanics and modeling<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/sites.uef.fi\/biophysics\/cell-mechanics-and-modeling\/\">Cell mechanics and modeling<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/sites.uef.fi\/biophysics\/functional-imaging\/\">Functional imaging<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/sites.uef.fi\/humea\/humea-laboratory\/human-motion-and-performance-analysis\/\">Motion analysis<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Funding<\/h4>\n\n\n    <div class=\"funders grid\">\n                        <a href=\"https:\/\/www.aka.fi\/en\/\" class=\"funders__link grid__item hover-scale-down\" title=\"Research Council of Finland\">\n                            <div class=\"funders__image\">\n                    <img decoding=\"async\" src=\"https:\/\/sites.uef.fi\/biophysics\/wp-content\/uploads\/sites\/87\/2023\/12\/research-council-of-finland-logo-horizontal-16-10.jpg\" alt=\"Research Council of Finland\" \/>\n                <\/div>\n                                    <p class=\"funders__description\">Research Council of Finland<\/p>\n                                                    <div class=\"funders__arrow\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"25px\" viewBox=\"0 -960 960 960\" width=\"24px\" ><path fill=\"currentColor\" d=\"M200-120q-33 0-56.5-23.5T120-200v-560q0-33 23.5-56.5T200-840h280v80H200v560h560v-280h80v280q0 33-23.5 56.5T760-120H200Zm188-212-56-56 372-372H560v-80h280v280h-80v-144L388-332Z\"\/><\/svg>                    <\/div>\n                <\/a>\n                            \n                        <a href=\"https:\/\/www.sigridjuselius.fi\/en\/\" class=\"funders__link grid__item hover-scale-down\" title=\"Sigrid Jus\u00e9lius Foundation\">\n                            <div class=\"funders__image\">\n                    <img decoding=\"async\" src=\"https:\/\/sites.uef.fi\/biophysics\/wp-content\/uploads\/sites\/87\/2024\/02\/SigridJuselius.png\" alt=\"Sigrid Jus\u00e9lius Foundation\" \/>\n                <\/div>\n                                    <p class=\"funders__description\">Sigrid Jus\u00e9lius Foundation<\/p>\n                                                    <div class=\"funders__arrow\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"25px\" viewBox=\"0 -960 960 960\" width=\"24px\" ><path fill=\"currentColor\" d=\"M200-120q-33 0-56.5-23.5T120-200v-560q0-33 23.5-56.5T200-840h280v80H200v560h560v-280h80v280q0 33-23.5 56.5T760-120H200Zm188-212-56-56 372-372H560v-80h280v280h-80v-144L388-332Z\"\/><\/svg>                    <\/div>\n                <\/a>\n                            \n            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Principal investigators Senior researchers &amp; postdocs Doctoral researchers Collaborators Overview Chondrocytes respond differently to varying loading conditions in articular cartilage and their deformations are thought to be related to tissue biosynthesis. Cell deformation behavior in human joints is affected by the applied loading and properties of the cartilage tissue surrounding cells. Altered loading and material [&hellip;]<\/p>\n","protected":false},"author":629,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-1438","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cell and Tissue Biomechanics - Biophysics Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell and Tissue Biomechanics - Biophysics Research Group\" \/>\n<meta property=\"og:description\" content=\"Principal investigators Senior researchers &amp; postdocs Doctoral researchers Collaborators Overview Chondrocytes respond differently to varying loading conditions in articular cartilage and their deformations are thought to be related to tissue biosynthesis. Cell deformation behavior in human joints is affected by the applied loading and properties of the cartilage tissue surrounding cells. Altered loading and material [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/\" \/>\n<meta property=\"og:site_name\" content=\"Biophysics Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-20T13:17:35+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/ramis-group\\\/\",\"url\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/ramis-group\\\/\",\"name\":\"Cell and Tissue Biomechanics - Biophysics Research Group\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/#website\"},\"datePublished\":\"2021-09-13T12:42:44+00:00\",\"dateModified\":\"2025-08-20T13:17:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/ramis-group\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/ramis-group\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/ramis-group\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cell and Tissue Biomechanics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/#website\",\"url\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/\",\"name\":\"Biophysics Research Group\",\"description\":\"Biophysics\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sites.uef.fi\\\/biophysics\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cell and Tissue Biomechanics - Biophysics Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/","og_locale":"en_US","og_type":"article","og_title":"Cell and Tissue Biomechanics - Biophysics Research Group","og_description":"Principal investigators Senior researchers &amp; postdocs Doctoral researchers Collaborators Overview Chondrocytes respond differently to varying loading conditions in articular cartilage and their deformations are thought to be related to tissue biosynthesis. Cell deformation behavior in human joints is affected by the applied loading and properties of the cartilage tissue surrounding cells. Altered loading and material [&hellip;]","og_url":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/","og_site_name":"Biophysics Research Group","article_modified_time":"2025-08-20T13:17:35+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/","url":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/","name":"Cell and Tissue Biomechanics - Biophysics Research Group","isPartOf":{"@id":"https:\/\/sites.uef.fi\/biophysics\/#website"},"datePublished":"2021-09-13T12:42:44+00:00","dateModified":"2025-08-20T13:17:35+00:00","breadcrumb":{"@id":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.uef.fi\/biophysics\/ramis-group\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.uef.fi\/biophysics\/ramis-group\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.uef.fi\/biophysics\/"},{"@type":"ListItem","position":2,"name":"Cell and Tissue Biomechanics"}]},{"@type":"WebSite","@id":"https:\/\/sites.uef.fi\/biophysics\/#website","url":"https:\/\/sites.uef.fi\/biophysics\/","name":"Biophysics Research Group","description":"Biophysics","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.uef.fi\/biophysics\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/pages\/1438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/users\/629"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/comments?post=1438"}],"version-history":[{"count":1,"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/pages\/1438\/revisions"}],"predecessor-version":[{"id":5730,"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/pages\/1438\/revisions\/5730"}],"wp:attachment":[{"href":"https:\/\/sites.uef.fi\/biophysics\/wp-json\/wp\/v2\/media?parent=1438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}