Clinical Epilepsy Research

Clinical Epilepsy Research build upon close collaboration between researchers within the University of Eastern Finland and Kuopio University Hospital Epilepsy Center. Professor Reetta Kälviäinen leads the research group with the focus on clinical epileptology including identifying biomarkers of seizure activity, epileptogenesis, progression, and drug-resistancy in cohorts of newly diagnosed and drug-resistant chronic patients. These aspects of scientific projects are combined with therapeutic neuropharmacological and neurosurgical interventions. The group uses genetic data from carefully phenotyped patient cohorts to discover genes related to epilepsy syndromes and to characterize patient disease trajectories. Reetta Kälviäinen is an expert of rare, neurodegenerative, progressive myoclonus epilepsies and has collected and deep-phenotyped the largest cohort of progressive myoclonus type 1 (EPM1) patients in the world.

The overall objective of the clinical epilepsy group is to optimize the treatment outcomes of patients with epilepsy both using current therapies but also striving to develop new more effective and safer treatments for tomorrow.  Our group achieves these goals through a multi-disciplinary team of investigators including specialists in adult and pediatric epileptology, neuropsychology, neurophysiology, neuroradiology, neuropathology, and genetics. We also immediately incorporate our research efforts in routine clinical care.

Clinical Epilepsy Research belongs to UEF Neuroscience Research Community NSciRC the goal of which is to understand the disease-specific and common molecular mechanisms underlying neurodegenerative diseases and epilepsy, and to identify biomarkers and novel therapeutic approaches for their prevention and cure by merging biological and computational neurosciences.