{"id":1047,"date":"2022-08-21T20:30:27","date_gmt":"2022-08-21T17:30:27","guid":{"rendered":"https:\/\/sites.uef.fi\/drug-targeting\/?page_id=1047"},"modified":"2026-07-03T17:59:34","modified_gmt":"2026-07-03T14:59:34","slug":"transporters","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/drug-targeting\/transporters\/","title":{"rendered":"Transporters We Study"},"content":{"rendered":"\n<p>Membrane transporters play a central role in the distribution and disposition of endogenous compounds, nutrients, metabolites, hormones, neurotransmitters, and therapeutic agents throughout the body. In particular, members of the Solute Carrier (SLC) and ATP-Binding Cassette (ABC) transporter families regulate the movement of molecules across biological membranes and therefore influence both physiology and pharmacotherapy.<\/p>\n\n\n\n<p>Our research focuses on understanding transporter function and exploiting these transport systems for targeted drug delivery. We investigate how transporters can be utilized to enhance drug delivery to specific organs, cell types, and intracellular organelles, as well as how modulation of transporter expression and function can improve therapeutic efficacy and safety.<\/p>\n\n\n\n<p><strong>Currently, our research encompasses the following transporter families and molecular targets <\/strong>(<em>more information behind the links)<\/em>:<\/p>\n\n\n\n<div class=\"links-block\">\n\n    \n    <ul class=\"link-list\">\n        \n            \n            <li class=\"link-list-item\">\n                <a href=\"https:\/\/sites.uef.fi\/drug-targeting\/transporters\/lat1\/\" class=\"link-reset link hover-scale-down\">\n                    <svg\n        width=\"43\" height=\"25\"\n        viewBox=\"0 0 43 25\"\n        xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path\n        d=\"M30.027 0 43 12.5 30.027 25 27 22.083 34.351 15H0v-5h34.351L27 2.917z\"\n        fill=\"currentColor\"\n        fill-rule=\"evenodd\"\/>\n<\/svg>                    <div>L-Type Amino Acid Transporter 1 (LAT1)<\/div>\n                <\/a>\n                <div class=\"link-info\">\n                                    <\/div>\n            <\/li>\n\n        \n            <li class=\"link-list-item\">\n                <a href=\"https:\/\/sites.uef.fi\/drug-targeting\/transporters\/oatps\/\" class=\"link-reset link hover-scale-down\">\n                    <svg\n        width=\"43\" height=\"25\"\n        viewBox=\"0 0 43 25\"\n        xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path\n        d=\"M30.027 0 43 12.5 30.027 25 27 22.083 34.351 15H0v-5h34.351L27 2.917z\"\n        fill=\"currentColor\"\n        fill-rule=\"evenodd\"\/>\n<\/svg>                    <div>Organic Anion Transporting Polypeptides (OATPs)<\/div>\n                <\/a>\n                <div class=\"link-info\">\n                                    <\/div>\n            <\/li>\n\n        \n            <li class=\"link-list-item\">\n                <a href=\"https:\/\/sites.uef.fi\/drug-targeting\/SNATs\" class=\"link-reset link hover-scale-down\">\n                    <svg\n        width=\"43\" height=\"25\"\n        viewBox=\"0 0 43 25\"\n        xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path\n        d=\"M30.027 0 43 12.5 30.027 25 27 22.083 34.351 15H0v-5h34.351L27 2.917z\"\n        fill=\"currentColor\"\n        fill-rule=\"evenodd\"\/>\n<\/svg>                    <div>Sodium-dependent Neutral Amino Acid Transporters (SNATs)<\/div>\n                <\/a>\n                <div class=\"link-info\">\n                                    <\/div>\n            <\/li>\n\n        \n            <li class=\"link-list-item\">\n                <a href=\"https:\/\/sites.uef.fi\/drug-targeting\/SMVT\" class=\"link-reset link hover-scale-down\">\n                    <svg\n        width=\"43\" height=\"25\"\n        viewBox=\"0 0 43 25\"\n        xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path\n        d=\"M30.027 0 43 12.5 30.027 25 27 22.083 34.351 15H0v-5h34.351L27 2.917z\"\n        fill=\"currentColor\"\n        fill-rule=\"evenodd\"\/>\n<\/svg>                    <div>Sodium-dependent Multivitamin Transporter (SMVT)<\/div>\n                <\/a>\n                <div class=\"link-info\">\n                                    <\/div>\n            <\/li>\n\n        \n            <li class=\"link-list-item\">\n                <a href=\"https:\/\/sites.uef.fi\/drug-targeting\/sglt1\/\" class=\"link-reset link hover-scale-down\">\n                    <svg\n        width=\"43\" height=\"25\"\n        viewBox=\"0 0 43 25\"\n        xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path\n        d=\"M30.027 0 43 12.5 30.027 25 27 22.083 34.351 15H0v-5h34.351L27 2.917z\"\n        fill=\"currentColor\"\n        fill-rule=\"evenodd\"\/>\n<\/svg>                    <div>Sodium\/Glucose Cotransporter 1 (SGLT1)<\/div>\n                <\/a>\n                <div class=\"link-info\">\n                                    <\/div>\n            <\/li>\n\n                <\/ul>\n<\/div>\n\n\n<p><em>In addition to membrane transporters, we investigate selected molecular targets involved in disease mechanisms and therapeutic development.<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-1024x683.jpg\" alt=\"\" class=\"wp-image-2370\" style=\"aspect-ratio:1.499259636168256;width:467px;height:auto\" srcset=\"https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-1024x683.jpg 1024w, https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-300x200.jpg 300w, https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-768x512.jpg 768w, https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-1536x1024.jpg 1536w, https:\/\/sites.uef.fi\/drug-targeting\/wp-content\/uploads\/sites\/59\/2026\/07\/FarmasiaKierros99-2048x1365.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Membrane transporters play a central role in the distribution and disposition of endogenous compounds, nutrients, metabolites, hormones, neurotransmitters, and therapeutic agents throughout the body. In particular, members of the Solute Carrier (SLC) and ATP-Binding Cassette (ABC) transporter families regulate the movement of molecules across biological membranes and therefore influence both physiology and pharmacotherapy. Our research [&hellip;]<\/p>\n","protected":false},"author":140,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-1047","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Transporters We Study - Transporter Targeted Drug Delivery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/drug-targeting\/transporters\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transporters We Study - Transporter Targeted Drug Delivery\" \/>\n<meta property=\"og:description\" content=\"Membrane transporters play a central role in the distribution and disposition of endogenous compounds, nutrients, metabolites, hormones, neurotransmitters, and therapeutic agents throughout the body. In particular, members of the Solute Carrier (SLC) and ATP-Binding Cassette (ABC) transporter families regulate the movement of molecules across biological membranes and therefore influence both physiology and pharmacotherapy. 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