{"id":96,"date":"2020-04-27T12:27:53","date_gmt":"2020-04-27T09:27:53","guid":{"rendered":"https:\/\/sites.uef.fi\/edcmet\/?page_id=96"},"modified":"2024-04-10T14:39:37","modified_gmt":"2024-04-10T11:39:37","slug":"partners","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/edcmet\/home\/partners\/","title":{"rendered":"Partners"},"content":{"rendered":"\t<div id=\"accordion-block_9a07e7561315a504d54b00cbca53db4b\" class=\"accordions\">\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-3533\" aria-expanded=\"false\" id=\"accordion-control-3533\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tUniversity of Eastern Finland\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-3533\" aria-hidden=\"true\" id=\"content-3533\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-298\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/UEF-logo.jpg\" alt=\"Logo\" width=\"250\" height=\"249\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/UEF-logo.jpg 278w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/UEF-logo-150x150.jpg 150w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/UEF-logo-100x100.jpg 100w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><br \/>\nThe University of Eastern Finland (UEF) is one of the largest universities in Finland with over 15000 students and 2500 staff members on two campuses. The Faculty of Health Sciences, located at the UEF Kuopio campus, is unique in Finland and offers education in medicine, pharmacy, dentistry, biomedicine and health sciences. The multidisciplinary research carried out at UEF is of high international standard and has been ranked among the best in several fields. The top-level international strategic research areas at the Faculty of Health Sciences departments participating to EDCMET, A.I.Virtanen Institute, Institute of Biomedicine and School of Pharmacy, address the global challenges of ageing, lifestyles and health, including cardiovascular and metabolic diseases.<\/p>\n<p>Within EDCMET, UEF is responsible for the overall coordination and management of the project. UEF scientists from five research groups will be involved in all scientific work packages, including identification of mechanisms of action of EDs in silico, development of ED screening methods using reporter assays, in vitro metabolic profiling of EDs and multi-omics analyses for ED-related AOP refinement and development, development of in vivo models to assess metabolic effects of EDs, and the search for biomarkers for ED exposure from human samples.<\/p>\n<p>At UEF, there are five research groups working in the project<\/p>\n<ul>\n<li>Vittorio Fortino, WP1<\/li>\n<li>Paavo Honkakoski, WP2<\/li>\n<li>Anna-Liisa Levonen, WP2 and WP3<\/li>\n<li>Jorma Palvimo, WP2<\/li>\n<li>Jaana Rys\u00e4, WP3 and WP4<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-63\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Levonen-Anna-Liisa-kuva.jpg\" alt=\"Anna-Liisa Levonen\" width=\"200\" height=\"280\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Levonen-Anna-Liisa-kuva.jpg 591w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Levonen-Anna-Liisa-kuva-214x300.jpg 214w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nAnna-Liisa Levonen<br \/>\nCoordinator, Professor<br \/>\nUniversity of Eastern Finland, A.I. Virtanen Institute<br \/>\ntel. +358 40 3589907<br \/>\nemail: anna-liisa.levonen (at) uef.fi<br \/>\nwebsite: <a href=\"https:\/\/www.uef.fi\/en\/etusivu\" target=\"_blank\" rel=\"noopener noreferrer\">www.uef.fi<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-4132\" aria-expanded=\"false\" id=\"accordion-control-4132\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tUniversity of Oulu\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-4132\" aria-hidden=\"true\" id=\"content-4132\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-304 size-full\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Oulu-logo.png\" alt=\"Logo\" width=\"475\" height=\"106\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Oulu-logo.png 475w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Oulu-logo-300x67.png 300w\" sizes=\"auto, (max-width: 475px) 100vw, 475px\" \/><\/p>\n<p>The University of Oulu (UOULU) is an international science university founded in 1958. UOULU community is 13500 students and 2800 employees strong, and one of the biggest and the most multidisciplinary universities in Finland. The university consists of eight faculties and many specialized research units. The university strategy is based on five thematic, internationally significant research focus areas: Creating sustainability by materials and systems, molecular and environmental basis of life-long health, digital solutions in sensing and interactions, earth and near-space system environmental change, and understanding humans in change. The Faculty of Medicine, an integral part of the Kontinkangas Life Sciences Campus, is situated next to the University Hospital of Oulu. The campus is a unique combination of partners in research, education, health services and business.<\/p>\n<p>Within EDCMET, UOULU leads two scientific work packages: WP3, In vivo models for the assessment of metabolic effects of EDs, and WP4, Population based assessment of exposure to chemicals and ED-related metabolic effects. The scientists aim to development and optimize protocols for in vivo tests, support alternative test development, discover novel methods and biomarkers of exposure in population studies, estimate human health risk of EDs, and to characterize of mode of action and adverse outcome pathway for selected EDs.<\/p>\n<p>In the University of Oulu, three research groups work in the project:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.oulu.fi\/mrc\/research-groups\/hakkola-hukkanen\" target=\"_blank\" rel=\"noopener noreferrer\">Jukka Hakkola<\/a>, WP3<\/li>\n<li>Arja Rautio, WP4<\/li>\n<li>Marjo-Riitta J\u00e4rvelin, WP4<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-241\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38-768x1024.jpg\" alt=\"Jukka Hakkola\" width=\"200\" height=\"267\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38-768x1024.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38-225x300.jpg 225w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38-1152x1536.jpg 1152w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38-1536x2048.jpg 1536w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Hakkola-Jukka-38.jpg 1772w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nJukka Hakkola, Professor<br \/>\nUniversity of Oulu, Research Unit of Biomedicine<br \/>\ntel: +358-924-485235<br \/>\nemail: jukka.hakkola(at)oulu.fi<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-256\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/RautioArja_DSC9422-1024x681.jpg\" alt=\"Arja Rautio\" width=\"301\" height=\"200\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/RautioArja_DSC9422-1024x681.jpg 1024w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/RautioArja_DSC9422-300x200.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/RautioArja_DSC9422-768x511.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/RautioArja_DSC9422.jpg 1515w\" sizes=\"auto, (max-width: 301px) 100vw, 301px\" \/><br \/>\nArja Rautio, Professor<br \/>\nUniversity of Oulu, Thule Institute and Faculty of Medicine<br \/>\ntel: +358 40 58 55 776<br \/>\nemail: arja.rautio(at)oulu.fi<\/p>\n<p>website: <a href=\"http:\/\/www.oulu.fi\" target=\"_blank\" rel=\"noopener noreferrer\">www.oulu.fi<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-6283\" aria-expanded=\"false\" id=\"accordion-control-6283\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tEurosafe\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-6283\" aria-hidden=\"true\" id=\"content-6283\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-280 size-full\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Eurosafe-logo.png\" alt=\"Logo\" width=\"329\" height=\"153\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Eurosafe-logo.png 329w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Eurosafe-logo-300x140.png 300w\" sizes=\"auto, (max-width: 329px) 100vw, 329px\" \/><\/p>\n<p>Eurosafe has long-standing experience of working in the field of absorption, distribution, metabolism and elimination (ADME), in vitro metabolism studies such as CYP enzyme phenotyping, inhibition and induction studies, transporters studies, drug-drug interaction studies for pre-clinical drug development. Eurosafe also has expertise in the domains of in silico studies such as structure modeling and molecular docking for protein structure prediction for individual or small set of proteins, toxicity screening and quantitative structure-activity relationship (QSAR) and tissue specific screening. The in silico omics studies also extend to search for signature sequences on HepaRG genome for toxicity prediction of test compounds and EDs.<\/p>\n<p>Within EDCMET, Eurosafe will participate to WPs 1, 2 and 5.<br \/>\nWP1: In silico methods to identify endocrine disrupting effects of chemicals<br \/>\nWP2: In vitro and omics methods to assess metabolic effects of Eds<br \/>\nWP5: Dissemination and outreach<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1357\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2023\/10\/Thomas-Darde.jpg\" alt=\"Thomas Darde\" width=\"250\" height=\"250\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2023\/10\/Thomas-Darde.jpg 400w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2023\/10\/Thomas-Darde-300x300.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2023\/10\/Thomas-Darde-150x150.jpg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><br \/>\nThomas Darde<br \/>\nemail: t.darde (at) wepredic.com<br \/>\nwebsite: <a href=\"https:\/\/www.eurosafecro.com\/en\">www.eurosafecro.com<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-192\" aria-expanded=\"false\" id=\"accordion-control-192\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tPamGene\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-192\" aria-hidden=\"true\" id=\"content-192\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-307\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Pamgene-logo2.jpg\" alt=\"Logo\" width=\"250\" height=\"117\" \/><\/p>\n<p>The Dutch biotech company PamGene has developed a micro array platform for activity proteomics, which allows for functional characterization of proteins and modulation thereof by compounds. The target protein is repeatedly pumped through a porous solid phase with immobilized probes and enables diffusion-independent interaction kinetics resulting in short assay time and thus preservation of target protein integrity.<\/p>\n<p>Using this approach, the activity of Nuclear Receptors (NRs), a family of ligand-activated transcription factors, is characterised through binding to a set of peptide probes representing a wide range of coregulator proteins. In vivo, the coregulators that are recruited by the NR at the target gen locus, modulate local chromatin structure thus regulate DNA accessibility for gene transcription by RNA polymerase. Differential (co)expression and utilisation of coregulators for cell types and genes play an important role in compound response.<\/p>\n<p>Characterisation of compounds through the Micro array Assay for Real-time Coregulator-Nuclear receptor Interaction (MARCoNI) has been successfully applied in various drug development programs as well as identification and characterisation of toxic substances.<\/p>\n<p>Within the in vitro WP2 of EDCMET, PamGene will subject a series of ED candidate chemicals to MARCoNI using a range of NRs. This screen will provide mechanistic data for the identification of compounds with a capability of canonical NR activity modulation. These data can be used to 1. generate or validate in silico models for target engagement and AOP (WP1), 2. bridge and validate in vitro assays (WP2) such as target binding and gene reporter assays and 3. functionally classify EDs for compound prioritisation and as a predictor for (differential) AOPs in general.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-714\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen-1024x1024.jpg\" alt=\"Rinie van Beuningen\" width=\"200\" height=\"200\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen-1024x1024.jpg 1024w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen-300x300.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen-150x150.jpg 150w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen-768x768.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/11\/Rinie-van-Beuningen.jpg 1321w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nRinie van Beuningen<br \/>\nVP Business Development<br \/>\nemail: rvbeuningen (at) pamgene.com<br \/>\ntel. +31 73 615 80 80<\/p>\n<p>website: <a href=\"https:\/\/www.pamgene.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.pamgene.com<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-7774\" aria-expanded=\"false\" id=\"accordion-control-7774\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tUniversity of Th\u00fcbingen\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-7774\" aria-hidden=\"true\" id=\"content-7774\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-277 size-full\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/EKUT-logo.png\" alt=\"Logo\" width=\"491\" height=\"157\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/EKUT-logo.png 491w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/EKUT-logo-300x96.png 300w\" sizes=\"auto, (max-width: 491px) 100vw, 491px\" \/><\/p>\n<p>Innovative, interdisciplinary, international: These three words summarize what makes the University of T\u00fcbingen special. Excellent research and teaching are T\u00fcbingen\u2019s answer to the challenges of the future in a globalized world. We maintain exchanges with partners around the globe \u2013 both at institutions of higher education and at non-university research institutions. Networks and cooperation across faculty and subject boundaries are the pillars of our successful strategy. This is reflected in our good position in international rankings. In addition, we are one of the eleven German universities distinguished with the title of \u201cexcellent.\u201d<\/p>\n<p>Within EDCMET, the Drug Design research group at Internal Medicine VIII will be engaged in molecular modeling and molecular dynamics simulations of different endocrine protein targets, especially nuclear receptors. The research group, lead by guest professor Antti Poso, will use novel computational methods to allow more precise evaluation and predictions of atomistic interactions between human proteins and potentially harmful compounds. The final aim is to develop better and more accurate ways to predict biological activity of organic compounds.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-235\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/AnttiPoso.jpg\" alt=\"Antti Poso\" width=\"160\" height=\"242\" \/><br \/>\nProfessor Antti Poso<br \/>\nemail: firstname.surname@uef.fi<br \/>\nphone: +358-40-3552462 (Mobile) and +49(0)7071-29 76969<\/p>\n<p>University Hospital T\u00fcbingen<br \/>\nDept. of Internal Medicine VIII<br \/>\nOtfried-M\u00fcller-Strasse 14<br \/>\n72076 T\u00fcbingen<br \/>\nGermany<\/p>\n<p>website: https:\/\/uni-tuebingen.de\/en\/<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-9630\" aria-expanded=\"false\" id=\"accordion-control-9630\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tCharles University\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-9630\" aria-hidden=\"true\" id=\"content-9630\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-274\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CharlesUniversityLogo.png-1024x206.jpg\" alt=\"Logo\" width=\"600\" height=\"121\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CharlesUniversityLogo.png-1024x206.jpg 1024w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CharlesUniversityLogo.png-300x60.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CharlesUniversityLogo.png-768x155.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CharlesUniversityLogo.png.jpg 1118w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>The Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9 continues in the old and long-time tradition of the education of pharmacy as well as pharmaceutical research at the Charles University. The research activities involve all aspects of contemporary pharmaceutical sciences and the Faculty of Pharmacy at the Charles University is in terms of scientific activity among the top institutions in the Czech Republic. Every year more than a hundred works successfully published in prestigious scientific journals are issued by our research staff, and our staff are the authors of a number of patents and inventions.<\/p>\n<p>Within EDCMET project, the group of Professor Pavek at the Department of Pharmacology and Toxicology will participate in development of cellular screening method for interaction testing of potential endocrine disruptors with nuclear receptors. In addition, we will work on animal models for analysis of hormonal and metabolic interference of endocrine disruptors.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-253\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/prof.P\u00e1vek.png\" alt=\"Petr Pavek\" width=\"200\" height=\"301\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/prof.P\u00e1vek.png 235w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/prof.P\u00e1vek-199x300.png 199w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nProf. PharmDr. Petr P\u00e1vek, Ph.D<br \/>\n<a href=\"https:\/\/portal.faf.cuni.cz\/Groups\/Group-of-Clinical-and-Molecular-Pharmacotherapy\/Research-Projects\/\" target=\"_blank\" rel=\"noopener noreferrer\">Website<\/a><br \/>\nCharles University, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9<br \/>\nDepartment of Pharmacology and Toxicology<br \/>\nAkademika Heyrovsk\u00e9ho 1203<br \/>\n500 05 Hradec Kr\u00e1lov\u00e9<br \/>\nthe Czech Republic<\/p>\n<p>websites: <a href=\"https:\/\/www.faf.cuni.cz\/?lang=en-gb\" target=\"_blank\" rel=\"noopener noreferrer\">www.faf.cuni.cz<\/a> and <a href=\"https:\/\/www.cuni.cz\/UKEN-1.html\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.cuni.cz\/UKEN-1.html<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-6488\" aria-expanded=\"false\" id=\"accordion-control-6488\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tWageningen University\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-6488\" aria-hidden=\"true\" id=\"content-6488\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-301\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Wageningen-logo.png\" alt=\"Logo\" width=\"350\" height=\"67\" \/><\/p>\n<p>The Division of Human Nutrition and Health at Wageningen University pursues an integrated approach in human nutrition education and research at the level of the cell, the individual, and the population. The Division covers the full causal chain from determinants of food choice to the impact of foods and nutrients on health and disease. Within this Division, the Nutrition, Metabolism and Genomics research group investigates the molecular mechanism of action of dietary nutrients and their impact on human health and metabolism.<\/p>\n<p>Within EDCMET, the Nutrition, Metabolism and Genomics group will be involved in the assessment of the metabolic effects of EDs using in vivo models and OMICS tools. The groups has long standing expertise in the study of metabolic dysfunction in rodent models, as well as in the application of OMICS tools in nutrition and metabolism research.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-259\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/SanderKersten.jpg\" alt=\"Sander Kersten\" width=\"200\" height=\"251\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/SanderKersten.jpg 265w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/SanderKersten-239x300.jpg 239w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nSander Kersten, PhD<br \/>\nProfessor of Nutrition, Metabolism and Genomics<br \/>\nDivision of Human Nutrition and Health<br \/>\nWageningen University<br \/>\nStippeneng 4<br \/>\n6708WE Wageningen<br \/>\nNetherlands<br \/>\nemail: firstname.surname@wur.nl<br \/>\nphone: +31 317 485787 or +31 317 485177<\/p>\n<p>website: https:\/\/www.wur.nl\/en\/wageningen-university.htm<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-1777\" aria-expanded=\"false\" id=\"accordion-control-1777\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tUniversity of Leeds\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-1777\" aria-hidden=\"true\" id=\"content-1777\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-283\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Leeds-logo-musta.png\" alt=\"Logo\" width=\"350\" height=\"102\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Leeds-logo-musta.png 417w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Leeds-logo-musta-300x87.png 300w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/p>\n<p>The University of Leeds (UoL) is a leading member of the UK\u2019s prestigious research-intensive Russell Group universities, and is ranked within the top 100 universities worldwide. In 2017, it was named the UK University of the Year for its outstanding commitment to student education (Times Higher). The most recent Research Excellence Framework (REF) exercise identified that &gt;82% of its research activity was either \u201cworld leading\u201d or \u201cinternationally excellent\u201d. Leeds hosts over 32,000 students from 141 countries attached to 560 different undergraduate and 300 postgraduate degree programmes. In 2015\/16, it had an annual income in excess of \u20ac752m and its annual research income exceeded \u20ac150m of which 14.3% was derived from EU awards.<\/p>\n<p>Within EDCMET, UoL will lead work-package 1, the in silico exploration of the effects of ED chemicals. Specifically, UoL will reconstruct a dynamic model of human liver metabolism, informed and validated by experimental data from the literature and other work-packages within EDCMET. We will use this model to explore how metabolic disruption by EDs can lead to fatty liver, a condition that is associated with long-term adverse health effects, including obesity, diabetes, and liver cancer. Through this approach, we aim to inform future risk assessments of the potential risk of ED exposure to human health.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-250\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/NickPlant.png\" alt=\"Nick Plant\" width=\"200\" height=\"190\" \/><br \/>\nProfessor Nick Plant<br \/>\nDean of Research Quality and Impact<br \/>\nProfessor of Systems Biology<br \/>\nemail: n.plant (at) leeds.ac.uk<\/p>\n<p>website: <a href=\"https:\/\/www.leeds.ac.uk\/\">www.leeds.ac.uk<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-6881\" aria-expanded=\"false\" id=\"accordion-control-6881\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tSpanish National Research Council\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-6881\" aria-hidden=\"true\" id=\"content-6881\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-268\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC-1024x402.jpg\" alt=\"Logo\" width=\"300\" height=\"118\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC-1024x402.jpg 1024w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC-300x118.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC-768x302.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC-1536x604.jpg 1536w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIC.jpg 2038w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-271\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIS-Idaea-logo.png\" alt=\"Logo\" width=\"250\" height=\"139\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIS-Idaea-logo.png 610w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/CSIS-Idaea-logo-300x167.png 300w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/p>\n<p>The Group of study on Trace Pollutants in Humans of the Department of Environmental Chemistry of the Institute of Environmental Assessment and Water Research (ID\u04d4A-CSIC) is devoted to the analysis of organic pollutants and metals of environmental or toxicological interest that are present in air, water, sediments, soils and organisms as well as those found at trace levels in human fluids such as serum, breast milk, urine, meconium, hair and exhaled breath. The developed methods are designed for the analysis of large numbers of samples to be consistent with the requirements of cohort studies. The group performs research on modelling the human intake processes of these compounds and participates in the study of correlations between internal pollutant doses and health effects.<\/p>\n<p>Within EDCMET, the group will study the concentrations of selected EDs such as hexachlorobenzene, 4,4\u2019-DDE and other DDT metabolites, polychlorobiphenyls (including congener 99), vinclozolin, 3-phenoxybenzoic acid, carbofuran and bisphenol A. Analytical methods for the analysis of these compounds in urine or serum will be developed if needed. In addition, new EDs identified upon application of EDselect will be measured in the samples collected from the cohorts as this group has recently acquired a GC-MS provided with a q-exactive Orbitrap that allows the non-target identification and quantification of compounds with high-resolution mass spectrometry. This partner has also LC-MS with the Orbitrap technology that allows obtaining mass spectra in scan modes without loss of sensitivity. This task will allow the experimental check of the in silico ED results by analyzing the new Eds in human fluids and study of the metabolic dysfunctions in the cohorts. CSIC has a strong expertise in the development of the analytical methods for analysis of trace constituents.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-244 size-full\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/JoanOGrimalt.jpg\" alt=\"Joan Grimalt\" width=\"196\" height=\"247\" \/><br \/>\nJoan O. Grimalt<br \/>\nDepartment of Environmental Chemistry<br \/>\nInstitute of Environmental Assessment and Water Research (IDAEA)<br \/>\nSpanish Council for Scientific Research (CSIC)<br \/>\nJordi Girona, 18<br \/>\n08034-Barcelona<br \/>\nphone: +34934006118<br \/>\nfax: +34932045904<br \/>\nemail: joan.grimalt (at) idaea.csic.es<br \/>\npersonal website:<a href=\"https:\/\/www.cid.csic.es\/homes\/grimalt\/\" target=\"_blank\" rel=\"noopener noreferrer\"> www.cid.csic.es\/homes\/grimalt\/<\/a><\/p>\n<p>website: <a href=\"https:\/\/www.idaea.csic.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.idaea.csic.es <\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-2012\" aria-expanded=\"false\" id=\"accordion-control-2012\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tGerman Federal Institute for Risk Assessment\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-2012\" aria-hidden=\"true\" id=\"content-2012\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-289\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Logo_BfR_Namen_100_prozent_CMYK.jpg\" alt=\"Logo\" width=\"400\" height=\"139\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Logo_BfR_Namen_100_prozent_CMYK.jpg 978w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Logo_BfR_Namen_100_prozent_CMYK-300x105.jpg 300w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/Logo_BfR_Namen_100_prozent_CMYK-768x268.jpg 768w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<div id=\"content\">\n<div id=\"main-content\" class=\"uefhae-subpage\" role=\"main\">\n<div class=\"portlet-layout row-fluid\">\n<div id=\"column-3\" class=\"portlet-column portlet-column-last spancol2\">\n<div id=\"layout-column_column-3\" class=\"portlet-dropzone portlet-column-content portlet-column-content-last\">\n<div id=\"p_p_id_56_INSTANCE_ZG5II4io9ROG_\" class=\"portlet-boundary portlet-boundary_56_ portlet-static portlet-static-end portlet-borderless portlet-journal-content \">\n<div class=\"portlet-borderless-container\">\n<div class=\"portlet-body\">\n<div class=\"journal-content-article\">\n<p>The German Federal Institute for Risk Assessment (BfR) is the national institute which prepares expert reports and opinions on questions concerning the safety of food, feed and chemicals, as well as consumer health protection, on the basis of internationally recognised scientific evaluation criteria. It advises the Federal Government and other institutions and interest groups in these areas. The BfR conducts its own research on topics that are closely linked to its assessment tasks. It is an institution with legal capacity within the portfolio of the German Federal Ministry of Food and Agriculture (BMEL).<\/p>\n<p>Within EDCMET, the Department of Food Safety of the BfR will be engaged in in vitro experimentation related to functional metabolic profiling of EDs and multi-omics analyses devoted to ED-related AOP refinement and development. BfR will also participate in the analyses of animal studies with selected EDs in order to elucidate in vivo effects and related AOPs. BfR will lead the EDCMET activities related to dissemination and outreach, including effective communication and stakeholder involvement, workshop organization, and communication of the project results to supranational bodies to foster future regulatory implementation of ED test systems.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-33\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-681x1024.jpg\" alt=\"Albert Braeuning\" width=\"200\" height=\"301\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-681x1024.jpg 681w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-200x300.jpg 200w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-768x1154.jpg 768w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-1022x1536.jpg 1022w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-1362x2048.jpg 1362w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/04\/Braeuning_Albert-scaled.jpg 1703w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\nAlbert Braeuning<br \/>\nGerman Federal Institute for Risk Assessment<br \/>\nMax-Dohrn-Str. 8-10<br \/>\n10589 Berlin<br \/>\nGermany<\/p>\n<p>email: pressestelle (at) bfr.bund.de<br \/>\nphone: +49-(0)30-18412-88000<br \/>\nfax: +49-(0)30-18412-22399<\/p>\n<p>website: <a href=\"https:\/\/www.bfr.bund.de\/en\/home.html\" target=\"_blank\" rel=\"noopener noreferrer\">www.bfr.bund.de<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"accordion accordion-js\">\n\t\t\t\t<button class=\"accordion__button\" aria-controls=\"content-2252\" aria-expanded=\"false\" id=\"accordion-control-2252\">\n\t\t\t\t\t<h3 class=\"accordion__heading\" >\n\t\t\t\t\t\tNorwegian University of Science and Technology\t\t\t\t\t<\/h3>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"accordion__content\" role=\"region\" aria-labelledby=\"accordion-control-2252\" aria-hidden=\"true\" id=\"content-2252\">\n\t\t\t\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-292 size-full\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/NTNU-logo.png\" alt=\"Logo\" width=\"390\" height=\"129\" srcset=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/NTNU-logo.png 390w, https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/NTNU-logo-300x99.png 300w\" sizes=\"auto, (max-width: 390px) 100vw, 390px\" \/><\/p>\n<p>Norwegian University of Science and Technology, department of Public Health and Nursing is one of eight international partners supported by the European Commission Horizon 2020 \u2013 Research and Innovation Framework Programme.<\/p>\n<p>The project Metabolic effects of Endocrine Disrupting Chemicals: novel testing methods and adverse outcome pathways (EDCMET), brings together experts in various research fields, toxicologists, biologists with understanding of the molecular mechanisms of metabolic disease, in vitro and in vivo methodological skills and epidemiologists linking environmental exposure to adverse metabolic outcomes.<\/p>\n<p>NTNU contributes in the project with own research on topics closely linked to its assessment tasks, such as population based studies. Endocrine disrupting chemicals in the human body, at birth, in childhood and later. Cohorts from Scandinavia, Russia and Spain with different exposure patterns are available. Estimation of human health risks for selected endocrine disrupting compounds will be evaluated.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-247\" src=\"https:\/\/sites.uef.fi\/edcmet\/wp-content\/uploads\/sites\/57\/2020\/05\/JonOOdland.png\" alt=\"Jon Oyvind Odland\" width=\"150\" height=\"198\" \/><br \/>\nProfessor Jon \u00d8yvind Odland<br \/>\nemail: jon.o.odland (at) ntnu.no<\/p>\n<p>website: <a href=\"https:\/\/www.ntnu.edu\/\">www.ntnu.edu<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":18,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-96","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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