Lähteet

Semifenaakki on kuvitteellinen lääkeaine, joka muistuttaa jonkin verran diklofenaakkia. Tehtävien taustalla on kirjallisuudessa esitettyjä tutkimustuloksia diklofenaakin farmakokinetiikasta.

Kirjallisuus

Ho HO, Liu CH, Lin HM, Sheu MT: The development of matrix tablets for diclofenac sodium based on an empirical in vitro and in vivo correlation. Journal of Controlled Release 49:149–156, 1997

Idkaidek NM, Amidon GL, Smith DE, Najib NM, Hassan MM: Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM. Biopharm Drug Dispos 19:169–174, 1998

Kambayashi  A, Blume H, Dressman J: Understanding the in Vivo Performance of Enteric Coated Tablets Using an in Vitro-In Silico-In Vivo Approach: Case Example Diclofenac. Eur J Pharm Biopharm 85(3 Pt B):1337-1347, 2013

Willis JV, Kendall MJ, Flinn RM, Thornhill DP, Welling PG: The pharmacokinetics of diclofenac sodium following intravenous and oral administration. European Journal of Clinical Pharmacology 16:405–410, 1979

Willis JV, Kendall MJ, Jack DB: The influence of food on the absorption of diclofenac after single and multiple oral doses. Eur J Clin Pharmacol 19(1):33-37, 1981