{"id":3997,"date":"2023-12-05T13:14:57","date_gmt":"2023-12-05T11:14:57","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=3997"},"modified":"2025-02-26T12:57:42","modified_gmt":"2025-02-26T10:57:42","slug":"pericytes-in-parkinsons-disease","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/pericytes-in-parkinsons-disease\/","title":{"rendered":"Pericytes in Parkinson\u2019s disease"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

The research aims to determine the role of pericytes in Parkinson\u2019s disease pathology. First, we want to discover how LRRK2 mutation affects the function of pericytes. Later we will assess how changes observed in the pericytes will reflect on the function of the blood-brain barrier. We will also determine the effect of Parkinson\u2019s disease like environment induced by exposure to alpha synuclein pre-formed fibrils, protein aggregating on Parkinson\u2019s disease, and pro-inflammatory cytokine IL-1b, the level of which is increased in cerebrospinal fluid of PD patients.<\/p>\n\n\n\n

Publications<\/h2>\n\n\n\n

Peltonen, S<\/strong>., Sonninen, T.-M., Niskanen, J., Koistinaho, J., Ruponen, M., Lehtonen, \u0160. (2024). Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells. Fluids Barriers CNS 21(1):92. https:\/\/doi.org\/10.1186\/s12987-024-00592-y<\/a><\/p>\n\n\n\n

Sonninen, T.-M., Peltonen, S<\/strong>., Niskanen, J., H\u00e4m\u00e4l\u00e4inen R.-H., Koistinaho, J., Lehtonen, \u0160. (2024) LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased \u03b1-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses. International Journal of Molecular Sciences 25(23):12874. https:\/\/doi.org\/10.3390\/ijms252312874<\/a><\/p>\n\n\n\n

Monikh, F. A., Lehtonen, \u0160., Kek\u00e4l\u00e4inen, J., Karkossa, I., Auriola, S., Schubert, K., Zanut, A., Peltonen, S<\/strong>., Niskanen, J., Bandekar, M., von Bergen, M., Leskinen, J., Bogialli, S., Guo, Z., Chen, C., Lynch, I. (2024) Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro Blood-Brain Barrier: An in-depth quantitative analysis. Nano Today 59, 102466.\u00a0https:\/\/doi.org\/10.1016\/j.nantod.2024.102466<\/a><\/p>\n\n\n\n

Albert, K., K\u00e4lv\u00e4l\u00e4, S., Hakosalo, V., Syv\u00e4nen, V., Krupa, P., Niskanen, J., Peltonen, S.<\/strong>, Sonninen, T.-M. & Lehtonen, \u0160. (2022). Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study. Biomedicines 10, 2649 https:\/\/doi.org\/10.3390\/biomedicines10102649<\/a> <\/p>\n\n\n\n

Wu, Y.-C., Sonninen, T.-M., Peltonen, S<\/strong>., Koistinaho, J., and Lehtonen, \u0160. (2021). Blood\u2013Brain Barrier and Neurodegenerative Diseases\u2014Modeling with iPSC-Derived Brain Cells. International Journal of Molecular Sciences 22, 7710.  https:\/\/doi.org\/10.3390\/ijms22147710<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The research aims to determine the role of pericytes in Parkinson\u2019s disease pathology. First, we want to discover how LRRK2 mutation affects the function of pericytes. Later we will assess how changes observed in the pericytes will reflect on the function of the blood-brain barrier. We will also determine the effect of Parkinson\u2019s disease like […]<\/p>\n","protected":false},"author":1034,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3997","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPericytes in Parkinson\u2019s disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/pericytes-in-parkinsons-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pericytes in Parkinson\u2019s disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"The research aims to determine the role of pericytes in Parkinson\u2019s disease pathology. 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