{"id":4004,"date":"2023-12-05T13:05:14","date_gmt":"2023-12-05T11:05:14","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=4004"},"modified":"2025-02-21T09:51:41","modified_gmt":"2025-02-21T07:51:41","slug":"microbiota-gut-brain-axis-in-parkinsons-disease-2","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/","title":{"rendered":"Microbiota-gut-brain-axis in Parkinson&#8217;s disease"},"content":{"rendered":"\n<p>The methodology employed in our study entails the use of models based on the gut-brain axis, incorporating human induced pluripotent stem cell-derived enteric neural cells and midbrain dopaminergic neurons, which are cultured on a microfluidic chip. Furthermore, human intestinal organoids will be used to model the gut in a more physiologically relevant context. We will assess the impact of alpha-synuclein pathology on the cells using healthy and PD donor cells. In addition, we will scrutinize the role of dysregulated gut microbiota and their mutual interplay with gut epithelial and neuronal cells and elucidate their role in alpha-synuclein pathology initiation as well as transfer to the brain.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"680\" src=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-1024x680.png\" alt=\"\" class=\"wp-image-4184\" srcset=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-1024x680.png 1024w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-300x199.png 300w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-768x510.png 768w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-1536x1019.png 1536w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4.png 1918w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>Figure<\/strong>: Conceptual figure of the project and preliminary data: (A-B) Representative images of enteric neurons forming axonal processes through the microchannels towards midbrain dopaminergic neurons on the gut-brain-axis chip. (C-D) Fluorescence images showing phosphorylated alpha-synuclein inclusions which are transferred with axonal processes to the midbrain dopaminergic neurons (E).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<p><strong>Syv\u00e4nen, V<\/strong>., Koistinaho J. &amp; Lehtonen \u0160. (2024). Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease. Expert Opin DrugDiscov. 2024 May;19(5):603-616. <a href=\"https:\/\/doi.org\/10.1080\/17460441.2024.2322988\">https:\/\/doi.org\/10.1080\/17460441.2024.2322988<\/a><\/p>\n\n\n\n<p>Albert, K., K\u00e4lv\u00e4l\u00e4, S., Hakosalo, V., <strong>Syv\u00e4nen, V.<\/strong>, Krupa, P., Niskanen, J., Peltonen, S., Sonninen, T-M. &amp; Lehtonen, \u0160. Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study, Biomedicines. 2022 Oct 20;10(10):2649. <a href=\"https:\/\/doi.org\/10.3390\/biomedicines10102649\">https:\/\/doi.org\/10.3390\/biomedicines10102649<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The methodology employed in our study entails the use of models based on the gut-brain axis, incorporating human induced pluripotent stem cell-derived enteric neural cells and midbrain dopaminergic neurons, which are cultured on a microfluidic chip. Furthermore, human intestinal organoids will be used to model the gut in a more physiologically relevant context. We will [&hellip;]<\/p>\n","protected":false},"author":1034,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4004","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Microbiota-gut-brain-axis in Parkinson&#039;s disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microbiota-gut-brain-axis in Parkinson&#039;s disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"The methodology employed in our study entails the use of models based on the gut-brain axis, incorporating human induced pluripotent stem cell-derived enteric neural cells and midbrain dopaminergic neurons, which are cultured on a microfluidic chip. 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We will [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-21T07:51:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1918\" \/>\n\t<meta property=\"og:image:height\" content=\"1273\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/\",\"name\":\"Microbiota-gut-brain-axis in Parkinson's disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4-1024x680.png\",\"datePublished\":\"2023-12-05T11:05:14+00:00\",\"dateModified\":\"2025-02-21T07:51:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/#primaryimage\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4.png\",\"contentUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-4.png\",\"width\":1918,\"height\":1273},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Microbiota-gut-brain-axis in Parkinson&#8217;s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\",\"name\":\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Microbiota-gut-brain-axis in Parkinson's disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/microbiota-gut-brain-axis-in-parkinsons-disease-2\/","og_locale":"en_US","og_type":"article","og_title":"Microbiota-gut-brain-axis in Parkinson's disease - Lehtonen lab\/ Human Brain Disease Modelling Research Group","og_description":"The methodology employed in our study entails the use of models based on the gut-brain axis, incorporating human induced pluripotent stem cell-derived enteric neural cells and midbrain dopaminergic neurons, which are cultured on a microfluidic chip. 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