{"id":4099,"date":"2024-07-29T14:49:26","date_gmt":"2024-07-29T11:49:26","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=4099"},"modified":"2024-08-26T13:07:14","modified_gmt":"2024-08-26T10:07:14","slug":"alternative-non-animal-methods-in-biomedical-research","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/alternative-non-animal-methods-in-biomedical-research\/","title":{"rendered":"Alternative non-animal methods in biomedical research\u00a0"},"content":{"rendered":"\n
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Course description:<\/strong> <\/strong>Animal models are important in biomedical research, yet they do not fully recapitulate human development or diseases and can be expensive. Non-animal methods, often known as \u201cin vitro\u201d or \u201cin silico\u201d, aim to reduce and partly replace the use of animals in scientific experiments. Their use also promotes the 3R principles in research and has become increasingly important since the FDA no longer requires animal experiments prior to human drug trials and the European Union has issued a directive to end all laboratory experiments within the EU (Directive 2010\/63\/EU). The aim of the course is to give students a comprehensive overview of the different non-animal methods used in biomedical research, industry, and toxicology testing. The course will also showcase the latest technologies, including organ-on-chip, and findings from using alternative methods. Speakers from academia, industry, and regulatory bodies will discuss their work using alternative non-animal methods. The students will have the opportunity to present their scientific work and to meet the speaker for informal interactions. There will also be opportunities to visit local biomedical research companies to learn about their work on alternative methods in practice.<\/p>\n\n\n\n

Credit points<\/strong>: 1-2 (1 ECTS for attendance at lectures; 2 ECTS for attendance at lectures, and a written report, a short summary of 1-2 lectures written after the course or a poster or presentation).<\/p>\n\n\n\n

Course director:<\/strong> \u0160\u00e1rka Lehtonen (UEF\/AIVI), board member of Finnish 3R for replacement<\/p>\n\n\n\n

Course co-organizers:<\/strong> Johanna Englund (UH), Jenni Hakkarainen (Experimentica), Virve Sihvola (ECHA)<\/p>\n\n\n\n

Venue:<\/strong> <\/strong>Kuopio campus, Medistudia building, room MS301, Yliopistonrinne 3, Kuopio<\/p>\n\n\n\n

26.-27.8. 2024 (Medistudia, UEF, Kuopio)<\/strong><\/p>\n\n\n\n

Registration: <\/strong>https:\/\/link.webropolsurveys.com\/Participation\/Public\/921c26ec-eacb-4ab1-8de9-f8bab28382f9?displayId=Fin3129106<\/a> <\/strong>by August 8th<\/sup>, 2024<\/strong><\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

DAY 1. (26.8.2024)<\/strong><\/p>\n\n\n\n

12.30 – 13.00  Registration<\/strong><\/p>\n\n\n\n

13.00 – 13.15  Welcome, practical matters and introduction of participants<\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

SESSION 1. Basic science session<\/strong><\/em> (chairperson \u0160\u00e1rka Lehtonen<\/em>)<\/p>\n\n\n\n

13.15 – 14.00\u00a0<\/strong>Plenary lecture Jonathan Curd <\/strong>(University of Nottingham, Co-founder & CEO PeptiMatrix): Customisable peptide hydrogels as user-defined biomimetic models of specific tissue microenvironments<\/p>\n\n\n\n

14.00 – 14.40  Coffee, exhibition and a poster session<\/p>\n\n\n\n

14.40 – 15.10  Hanna Vuorenp\u00e4\u00e4<\/strong> (Tampere University): In vitro models in replacing animal models -new era of Organ-on-Chip technology<\/p>\n\n\n\n

15.10 – 15.40  Erdogan Pekcan Erkan<\/strong> (Tampere University): Imperfect, yet useful: modeling abdominal cancers with patient-derived tumor organoids<\/p>\n\n\n\n

15.40 – 16.10  Maria Hytti<\/strong> (UEF) Exploring disease mechanisms using induced pluripotent stem cell-derived cells from patients and healthy controls \u2013 focus on age-related macular degeneration<\/p>\n\n\n\n

16.10 – 16.40  Prateek Singh<\/strong> (Founder & CEO Finnadvance): Open architecture microfluidics for scalable organ-on-chips<\/p>\n\n\n\n

16.40 \u2013 17.00 Meet the speakers<\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

DAY 2. (27.8.2024)<\/strong><\/p>\n\n\n\n

SESSION 2.<\/strong><\/em> <\/em><\/strong>Regulatory bodies + Companies<\/em><\/strong><\/p>\n\n\n\n

09.00 – 09.45\u00a0 Plenary lecture\u00a0Sirpa Pietik\u00e4inen<\/strong>\u00a0(<\/strong>Member\u00a0of EPPA)<\/strong><\/p>\n\n\n\n

09.45 – 10.15   Elina Brusila<\/strong> (ECHA): Regulatory Application – Alternative methods to industrial chemicals<\/p>\n\n\n\n

10.15 – 10.45   Coffee, exhibition and a poster session<\/p>\n\n\n\n

10.45 – 11.15    Pauliina Lehtolainen-Dalkilic<\/strong> (FIMEA): Regulatory perspective update:  how EMA and National Agencies are advancing 3Rs<\/p>\n\n\n\n

11.15 – 11.45   Tony Kiuru<\/strong> (UPM): GrowDex \u2013 Animal-free option for automated 3D cell culture assays<\/p>\n\n\n\n

Student presentations<\/strong><\/p>\n\n\n\n

11.45 – 11.55 \u00a0 Sara K\u00e4lv\u00e4l\u00e4<\/strong> (UEF): Midbrain organoids at the air-liquid interface recapitulate alpha-synuclein pathology in a human a human brain-like in vitro model<\/p>\n\n\n\n

11.55 – 12.05 \u00a0 Kateryna Gaertner <\/strong>(Tampere University): Hare fibroblasts reveal a species difference in glycerol-3-phosphate metabolism associated with adaptive thermogenesis<\/p>\n\n\n\n

12.05 – 12.15 \u00a0 Johanna Englund <\/strong>(FIN3R replacement)<\/p>\n\n\n\n

12.15 – 13.00   Lunch and exhibition<\/p>\n\n\n\n

<\/p>\n\n\n\n

SESSION 3. Companies<\/strong><\/em> (chairperson Jenni Hakkarainen)<\/p>\n\n\n\n

13.00 – 13.45   Plenary lecture Melina Malinen<\/strong> (ORION): Advancing Drug Discovery: Harnessing Human-Based Alternatives<\/p>\n\n\n\n

13.45 – 13.55   Wrapping up the course<\/strong><\/p>\n\n\n\n

13.55 – 14.15   Coffee and exhibition<\/p>\n\n\n\n

14.45 – 16:00   Visit to company 1 –Experimentica Ltd  <\/strong>2×30 min, 12+12 students<\/p>\n\n\n\n

14.45 – 16:00   Visit to company 2 –Ferring VENTURE Oy<\/strong> 2×30, 12+12 students<\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Course description: Animal models are important in biomedical research, yet they do not fully recapitulate human development or diseases and can be expensive. Non-animal methods, often known as \u201cin vitro\u201d or \u201cin silico\u201d, aim to reduce and partly replace the use of animals in scientific experiments. Their use also promotes the 3R principles in research and […]<\/p>\n","protected":false},"author":1034,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4099","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nAlternative non-animal methods in biomedical research\u00a0 - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/alternative-non-animal-methods-in-biomedical-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alternative non-animal methods in biomedical research\u00a0 - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"Course description: Animal models are important in biomedical research, yet they do not fully recapitulate human development or diseases and can be expensive. 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