{"id":4186,"date":"2025-02-17T13:58:38","date_gmt":"2025-02-17T11:58:38","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=4186"},"modified":"2025-02-26T13:10:21","modified_gmt":"2025-02-26T11:10:21","slug":"the-impact-of-environment-polluting-agents-in-parkinsons-disease","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/the-impact-of-environment-polluting-agents-in-parkinsons-disease\/","title":{"rendered":"The impact of environment polluting agents in Parkinson\u2019s disease\u00a0"},"content":{"rendered":"\n

Despite ongoing research, the evidence is inconclusive regarding whether exposure to microparticles induce neuroinflammation and drives neurodegeneration in PD. To address this knowledge gap, the concept idea of the project is illustrated below: <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Publications<\/h2>\n\n\n\n

Monikh, FA., Lehtonen, \u0160.<\/em><\/strong>, Kek\u00e4l\u00e4inen, J., Karkossa, I., et al. 2024<\/strong> Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis. Nanotoday, <\/em>59, 102466 https:\/\/doi.org\/10.1016\/j.nantod.2024.102466<\/a><\/p>\n\n\n\n

Guden, D.S.<\/strong>, Temiz-Resitoglu, M., Senol, S.P., Kibar, D., et al. 2021<\/strong> mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats. Can. J. Physiol. Pharmacol.,<\/em> 99(9), 921\u2013934 https:\/\/doi.org\/10.1139\/cjpp-2020-0487<\/a><\/p>\n\n\n\n

Guden, D.S<\/strong>., Ar\u0131c\u0131oglu, F.  2020<\/strong>. A link between PKR, inflammasome and synaptic plasticity:   is it an emerging therapeutic option for cognitive dysfunction? Psychiatry and Clinical Psychopharmacology<\/em>, 30(3), 313 https:\/\/doi.org\/10.5455\/pcp.20200801015342<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Despite ongoing research, the evidence is inconclusive regarding whether exposure to microparticles induce neuroinflammation and drives neurodegeneration in PD. To address this knowledge gap, the concept idea of the project is illustrated below:  Publications Monikh, FA., Lehtonen, \u0160., Kek\u00e4l\u00e4inen, J., Karkossa, I., et al. 2024 Biotransformation of nanoplastics in human plasma and their permeation through a model […]<\/p>\n","protected":false},"author":1034,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4186","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nThe impact of environment polluting agents in Parkinson\u2019s disease\u00a0 - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/the-impact-of-environment-polluting-agents-in-parkinsons-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The impact of environment polluting agents in Parkinson\u2019s disease\u00a0 - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"Despite ongoing research, the evidence is inconclusive regarding whether exposure to microparticles induce neuroinflammation and drives neurodegeneration in PD. To address this knowledge gap, the concept idea of the project is illustrated below:  Publications Monikh, FA., Lehtonen, \u0160., Kek\u00e4l\u00e4inen, J., Karkossa, I., et al. 2024 Biotransformation of nanoplastics in human plasma and their permeation through a model […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/the-impact-of-environment-polluting-agents-in-parkinsons-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-26T11:10:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-8.png\" \/>\n\t<meta property=\"og:image:width\" content=\"618\" \/>\n\t<meta property=\"og:image:height\" content=\"1125\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/the-impact-of-environment-polluting-agents-in-parkinsons-disease\/\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/the-impact-of-environment-polluting-agents-in-parkinsons-disease\/\",\"name\":\"The impact of environment polluting agents in Parkinson\u2019s disease\u00a0 - 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