{"id":426,"date":"2021-05-17T09:35:23","date_gmt":"2021-05-17T06:35:23","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=426"},"modified":"2025-10-06T11:41:59","modified_gmt":"2025-10-06T08:41:59","slug":"key-publications","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain.<\/strong> Albert, K<\/span><\/strong>., Peltonen, S., Vanne, A., K\u00e4lv\u00e4l\u00e4, S., Syv\u00e4nen, V., Koistinaho, J., Luk, K.C., Lehtonen, \u0160.<\/span><\/strong> (2025) Brain, Behavior, and Immunity<\/em> 130, 106097. Open access<\/a>
<\/p>\n\n\n\n

From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells.<\/strong> Sonninen, T.-M., Peltonen, S., K\u00e4lv\u00e4l\u00e4, S., Nguyen, H.-T., Ruponen, M., Singh, P., Lehtonen, \u0160.<\/span><\/strong> (2025) Fluids and Barriers of the CNS<\/em> 22, 58. <\/p>\n\n\n\n

Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis.<\/strong> Monikh, FA., Lehtonen, \u0160.<\/em><\/u><\/strong>, Kek\u00e4l\u00e4inen, J., Karkossa, I., Auriola, S., Schubert, K., Zanut, A., Leskinen, J., Bogialli, S., Guo Z., Kukkonen, J., Chen, C., Lynch, I. (2024) Nano today <\/em>59:102466.<\/p>\n\n\n\n

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces abberant phenotype in human microglia.<\/strong> Niskanen, J., Peltonen, S., Fazaludeen MF., Giudice, L., Luk, KC., Koistinaho, J., Malm, T., Goldsteins, G., Albert, K., Lehtonen, \u0160.<\/u><\/strong> (2024) Glia <\/em>24626, 1098-1136.<\/p>\n\n\n\n

Beta-amyloid overproduction induces cerebral amyloid angiopathy-like changes in human iPSC-derived mural cells.<\/em><\/strong> <\/em>Wu,Y-Ch., Lehtonen,\u0160<\/u><\/strong>., Trontti,K., Leinonen,V., Laakso,M., Kuusisto,J., Hovatta,I., Rolova,T., Koistinaho, J. (2024) Fluids and barriers of the CNS <\/em>21(1):78.<\/p>\n\n\n\n

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia.<\/strong> Orhan, F., Malwade, S., Khanlarkhani, N., Gkoga, A., Langeder, A., Jungholm, O., Koskuvi, M., Lehtonen, \u0160.,<\/u><\/strong> Schwieler, L., Jardemark, K., Tiihonen, J., Koistinaho, J., Erhardt, S., Engberg, G., Samudyata, S., Sellgren, CM (2024) accepted to Am J. Psychiatry<\/em><\/p>\n\n\n\n

Novel therapeutic strategies and common mechanism of neurodegenerative diseases.Lehtonen,\u0160<\/u><\/strong>. and Jolkkonen, J. (2024)  Neuroprotection (editorial) https:\/\/doi.org\/10.1002\/nep3.52<\/em><\/p>\n\n\n\n

Perspective on stem cell transplantation in brain diseases<\/strong>. Albert, K., Goldsteine, G., K\u00e4lv\u00e4l\u00e4, S., Jolkkonen, J.,Lehtonen, \u0160.<\/em><\/u><\/strong> (2024) Translational Medicine<\/em> Communications <\/em>9:22.<\/p>\n\n\n\n

Presenilin-1 \u0394E9 mutation associated sarcoplasmic reticulum leak alters [Ca2+<\/sup>]i <\/sub>distribution in human iPSC-derived cardiomyocytes.<\/strong> Naumenko, N., Koivum\u00e4ki, JT., Lunko, O., Tuomainen, T., Leigh, R., Rabie, M., Laurila, J., Oksanen, M., Lehtonen, \u0160.,<\/u><\/strong> Koistinaho, J. and Tavi, P. (2024) J Mol and Cell Cardiol <\/em>193: 78-87.<\/p>\n\n\n\n

Induced pluripotent stem cell-derived microglia to study NLRP3 inflammasome activation in Alzheimer\u2019s disease.<\/strong> Erdogan \u00d6ner, A., Dansokho, C., Koistinaho, J., Lehtonen, \u0160.<\/u><\/strong>, Solakoglu, S., Heneka, MT (2024) J Ist Faculty Med 2024 DOI: 10.26650\/IUITFD.1451011<\/em><\/p>\n\n\n\n

The link between Amyloid \u03b2 and ferroptosis pathway in Alzheimer\u2019s disease progression.<\/strong> Majern\u00edkov\u00e1, N., Marmolejo-Garza, A., Salinas, C., Luu, M., Zhang, Y., Trombetta-Lima, M., Tomin, T., Birner-Gruenberge, R., Lehtonen, \u0160<\/u>.<\/em><\/strong>, Koistinaho, J., Wolters, J., Ayton, S., den Dunnen WFA., Dolga, AM.  (2024) accepted to Cell Death & Disease <\/em>15:782.<\/p>\n\n\n\n

The impact of VEGF-C-induced dural lymphatic vessel growth on ischemic stroke pathology<\/strong>. Keuters, MH., Antilla, S., Immonen, R., Plotnikova, L., Wojciechowski, S., Lehtonen,\u0160<\/u><\/strong>., Alitalo, K., Koistinaho, J., Dhungana, H. (2024) Transl Stroke Res <\/em>doi: 10.1007\/s12975-024-01262-9. <\/p>\n\n\n\n

Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia. <\/strong>Spathopoulou, A., Fenkart, G., Marteau, V., Podlesnic, M., Kruszewski K., Koskuvi, M., Rethelyi, J., Ap\u00e1ti, A., Conti, L., Ku, M., Koal, T., M\u00fcller, U., Talmazan, R., Ojansuu, I., Vaurio, O., L\u00e4hteenvuo, M., Lehtonen, \u0160.,<\/u><\/strong> Mertens, J., G\u00fcnther, K., Tiihonen, J., Koistinaho, J., Trajanoski, Z., Edenhofer, F. (2024) Mol Psychiatry <\/em>29(10):3128-3140<\/p>\n\n\n\n

Astrocytes regulate neuronal network burst frequency through NMDA receptors species- and donor-specifically.<\/strong> R\u00e4s\u00e4nen, N., Tiihonen, J., Koskuvi, M., Lehtonen,\u0160<\/u><\/strong>., Jalkanen, N., Karmila, N., Weert, I., Pietil\u00e4inen, O., Koistinaho, J. (2024) Biological Psychiatry<\/em>: Global Open Science <\/em>4(4):100313.<\/p>\n\n\n\n

Genetic contribution to microglial activation in schizophrenia.<\/strong> Koskuvi, M., P\u00f6rsti, E., Hewitt, T., R\u00e4s\u00e4nen, N., Wu, YC., Trontti, K., McQuade, A., Ojansuu, I., Vario, O., Cannon, T., L\u00f6nnqvist, J., Therman, S., Suvisaari, J., Kaprio, J., Blurton-Jones, M., Hovatta, I., L\u00e4hteenvuo, M., Rolova, T., Lehtonen \u0160.,<\/u><\/strong> Tiihonen, J.,Koistinaho, J. (2024) Mol Psychiatry <\/em>29(9): 2622-2633.<\/p>\n\n\n\n

Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease.<\/strong> Syv\u00e4nen, V., Koistinaho, J., Lehtonen, \u0160.<\/u><\/strong>(2024) Expert Opin Drug Discov <\/em>19(5):603-616.<\/p>\n\n\n\n

Particulate matter from car exhaust alters function of human iPSC-derived microglia.<\/strong> J\u00e4ntti, H., Jonk, S., Gomez-Budia, M., Ohtonen, S., Fagerlund, I., Fazaludeen, MF., Aakko-Saksa, P., Pebay, A., Lehtonen, \u0160.,<\/u><\/strong> Koistinaho, J., Kanninen, KM., Jalava, PI., Malm, T., Korhonen, P. (2024) Part Fibre Toxicol <\/em>21(1):6.<\/p>\n\n\n\n

Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling.<\/strong> Nguyen, H-T., Rissanen S-L., Peltokangas, M., Laakkonen, T., Ketunen, J., Barthod, L., Sivakumar, R., Paloj\u00e4rvi, A., Junttila, P., Talvitie, J., Bassis, M., Nickels, SL., K\u00e4lv\u00e4l\u00e4, S., Lehtonen, \u0160.,<\/u><\/strong> Schwamborn, JC, Mosser, S., Singh, P. (2024) Tissue Barriers <\/em>doi: 10.1080\/21688370.2024.2315702.<\/p>\n\n\n\n

Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson\u2019s disease related transcriptional profile and functions.<\/strong> Ohtonen, S., Giudice, L., J\u00e4ntti, H., Fazaludeen, F., Shakirzyanova, A., Gomez-Budia, M., V\u00e4lim\u00e4ki, NN., Korvenlaita, N., Fagerlund, I., Bruder, J., Renner, H., Sch\u00f6ler, H., Koistinaho, J., Amiry-Moghaddam, M., Savchenko, E., Roybon, L., Lehtonen, \u0160<\/u>.,<\/em><\/strong> Korhonen, P., Malm, T. (2023) Scientific Reports<\/em> 13 (1):22118.<\/p>\n\n\n\n

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.<\/strong> Kettunen, P., Lesnikova, A., R\u00e4s\u00e4nen, N., Ojha, R., Palmunen, L., Laakso, M., Lehtonen, \u0160., Kuusisto, J., Pietil\u00e4inen, O., Saber, S. H., Joensuu, M., Vapalahti, O. P., Koistinaho, J., Rolova, T., & Balistreri, G. (2023). Journal of Virology<\/em>, 97<\/em>(4), e00144-23.<\/p>\n\n\n\n

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction.<\/strong> Sabogal-Gu\u00e1queta, A. M., Marmolejo-Garza, A., Trombetta-Lima, M., Oun, A., Hunneman, J., Chen, T., Koistinaho, J., Lehtonen, S., Kortholt, A., Wolters, J. C., Bakker, B. M., Eggen, B. J. L., Boddeke, E., & Dolga, A. (2023). Nature Communications<\/em>, 14<\/em>(1), 6454.<\/p>\n\n\n\n

Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study.<\/strong> Albert, K., K\u00e4lv\u00e4l\u00e4, S., Hakosalo, V., Syv\u00e4nen, V., Krupa, P., Niskanen, J., Peltonen, S., Sonninen, T.-M., & Lehtonen, \u0160. (2022). Biomedicines<\/em>, 10<\/em>(10), 2649.<\/p>\n\n\n\n

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases.<\/strong> Goldsteins, G., Hakosalo, V., Jaronen, M., Keuters, M. H., Lehtonen, \u0160., & Koistinaho, J. (2022). Antioxidants<\/em>, 11<\/em>(2), 405.<\/p>\n\n\n\n

Microglial amyloid beta clearance is driven by PIEZO1 channels.<\/strong> J\u00e4ntti, H., Sitnikova, V., Ishchenko, Y., Shakirzyanova, A., Giudice, L., Ugidos, I. F., G\u00f3mez-Budia, M., Korvenlaita, N., Ohtonen, S., Belaya, I., Fazaludeen, F., Mikhailov, N., Gotkiewicz, M., Ketola, K., Lehtonen, \u0160., Koistinaho, J., Kanninen, K. M., Hern\u00e1ndez, D., P\u00e9bay, A., \u2026 Malm, T. (2022). Journal of Neuroinflammation<\/em>, 19<\/em>(1), 147<\/p>\n\n\n\n

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia.<\/strong> Koskuvi, M., Lehtonen, \u0160., Trontti, K., Keuters, M., Wu, Y., Koivisto, H., Ludwig, A., Plotnikova, L., Virtanen, P. L. J., R\u00e4s\u00e4nen, N., Kaipainen, S., Hy\u00f6tyl\u00e4inen, I., Dhungana, H., Giniatullina, R., Ojansuu, I., Vaurio, O., Cannon, T. D., L\u00f6nnqvist, J., Therman, S., \u2026 Koistinaho, J. (2022). Glia<\/em>, 70<\/em>(4), 650\u2013660.<\/p>\n\n\n\n

The iPSC perspective on schizophrenia.<\/strong> R\u00e4s\u00e4nen, N., Tiihonen, J., Koskuvi, M., Lehtonen, \u0160., & Koistinaho, J. (2022). Trends in Neurosciences<\/em>, 45<\/em>(1), 8\u201326.<\/p>\n\n\n\n

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice.<\/strong> V\u00e4lim\u00e4ki, N.-N., Bakreen, A., H\u00e4kli, S., Dhungana, H., Keuters, M. H., Dunlop, Y., Koskuvi, M., Keksa-Goldsteine, V., Oksanen, M., J\u00e4ntti, H., Lehtonen, \u0160., Malm, T., Koistinaho, J., & Jolkkonen, J. (2022). Stroke<\/em>, 53<\/em>(10), 3192\u20133201.<\/p>\n\n\n\n

Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia. <\/strong>Albert, K., Niskanen, J., K\u00e4lv\u00e4l\u00e4, S., & Lehtonen, \u0160. (2021). International Journal of Molecular Sciences<\/em>, 22<\/em>(9), 4334.<\/p>\n\n\n\n

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids.<\/strong> Fagerlund, I., Dougalis, A., Shakirzyanova, A., G\u00f3mez-Budia, M., Pelkonen, A., Konttinen, H., Ohtonen, S., Fazaludeen, M. F., Koskuvi, M., Kuusisto, J., Hern\u00e1ndez, D., Pebay, A., Koistinaho, J., Rauramaa, T., Lehtonen, \u0160., Korhonen, P., & Malm, T. (2021). Cells<\/em>, 11<\/em>(1), 124.<\/p>\n\n\n\n

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo.<\/strong> Keuters, M. H., Keksa-Goldsteine, V., Dhungana, H., Huuskonen, M. T., Pomeshchik, Y., Savchenko, E., Korhonen, P. K., Singh, Y., Wojciechowski, S., Lehtonen, \u0160., Kanninen, K. M., Malm, T., Sirvi\u00f6, J., Muona, A., Koistinaho, M., Goldsteins, G., & Koistinaho, J. (2021). Scientific Reports<\/em>, 11<\/em>(1), 3518.<\/p>\n\n\n\n

Metabolic and immune dysfunction of glia in neurodegenerative disorders: Focus on iPSC models.<\/strong> R\u00f5lova, T., Lehtonen, \u0160., Goldsteins, G., Kettunen, P., & Koistinaho, J. (2021). Stem Cells<\/em>, 39<\/em>(3), 256\u2013265.<\/p>\n\n\n\n

Studying non\u2013cell-autonomous neurodegeneration in Parkinson\u2019s disease with induced pluripotent stem cells. <\/strong>Sonninen, T.-M., Plotnikova, L., Laham-Karam, N., Goldsteins, G., Koistinaho, J., & Lehtonen, \u0160. (2021). In IPSCs for Modeling Central Nervous System Disorders<\/em> (pp. 251\u2013276). Elsevier.<\/p>\n\n\n\n

Molecular signaling pathways underlying schizophrenia.<\/strong> Tiihonen, J., Koskuvi, M., L\u00e4hteenvuo, M., Trontti, K., Ojansuu, I., Vaurio, O., Cannon, T. D., L\u00f6nnqvist, J., Therman, S., Suvisaari, J., Cheng, L., Tanskanen, A., Taipale, H., Lehtonen, \u0160., & Koistinaho, J. (2021). Schizophrenia Research<\/em>, 232<\/em>, 33\u201341.<\/p>\n\n\n\n

Blood\u2013Brain Barrier and Neurodegenerative Diseases\u2014Modeling with iPSC-Derived Brain Cells.<\/strong> Wu, Y.-C., Sonninen, T.-M., Peltonen, S., Koistinaho, J., & Lehtonen, \u0160. (2021). International Journal of Molecular Sciences<\/em>, 22<\/em>(14), 7710.<\/p>\n\n\n\n

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.<\/strong> Grubman, A., Vandekolk, T. H., Schr\u00f6der, J., Sun, G., Hatwell-Humble, J., Chan, J., Oksanen, M., Lehtonen, S., Hunt, C., Koistinaho, J. E., Nilsson, S. K., Haynes, J. M., Pouton, C. W., & Polo, J. M. (2020). Stem Cell Reports<\/em>, 14<\/em>(6), 1018\u20131032.<\/p>\n\n\n\n

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery.<\/strong>  Oikari, L. E., Pandit, R., Stewart, R., Cun\u00ed-L\u00f3pez, C., Quek, H., Sutharsan, R., Rantanen, L. M., Oksanen, M., Lehtonen, S., De Boer, C. M., Polo, J. M., G\u00f6tz, J., Koistinaho, J., & White, A. R. (2020). Stem Cell Reports<\/em>, 14<\/em>(5), 924\u2013939.<\/p>\n\n\n\n

NF\u2010E2\u2010related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin\u20101 mutated Alzheimer\u2019s disease astrocytes. <\/strong>Oksanen, M., Hy\u00f6tyl\u00e4inen, I., Trontti, K., Rolova, T., Wojciechowski, S., Koskuvi, M., Viitanen, M., Levonen, A., Hovatta, I., Roybon, L., Lehtonen, \u0160., Kanninen, K. M., H\u00e4m\u00e4l\u00e4inen, R. H., & Koistinaho, J. (2020). Glia<\/em>, 68<\/em>(3), 589\u2013599.<\/p>\n\n\n\n

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer\u2019s disease. <\/strong>Rolova, T., Wu, Y.-C., Koskuvi, M., Voutilainen, J., Sonninen, T.-M., Kuusisto, J., Laakso, M., H\u00e4m\u00e4l\u00e4inen, R. H., Koistinaho, J., & Lehtonen, \u0160. (2020). Stem Cell Research<\/em>, 48<\/em>, 101968.<\/p>\n\n\n\n

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases.<\/strong> Sonninen, T.-M., Goldsteins, G., Laham-Karam, N., Koistinaho, J., & Lehtonen, \u0160. (2020). Cells<\/em>, 9<\/em>(10), 2183.<\/p>\n\n\n\n

Metabolic alterations in Parkinson\u2019s disease astrocytes. <\/strong>Sonninen, T.-M., H\u00e4m\u00e4l\u00e4inen, R. H., Koskuvi, M., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, K., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J., & Lehtonen, \u0160. (2020). Scientific Reports<\/em>, 10<\/em>(1), 14474.<\/p>\n\n\n\n

Neurobiological roots of psychopathy.<\/strong> Tiihonen, J., Koskuvi, M., L\u00e4hteenvuo, M., Virtanen, P. L. J., Ojansuu, I., Vaurio, O., Gao, Y., Hy\u00f6tyl\u00e4inen, I., Puttonen, K. A., Repo-Tiihonen, E., Paunio, T., Rautiainen, M.-R., Tyni, S., Koistinaho, J., & Lehtonen, \u0160. (2020). Molecular Psychiatry<\/em>, 25<\/em>(12), 3432\u20133441.<\/p>\n\n\n\n

PSEN1<\/strong>\u0394<\/strong>E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. <\/strong>Konttinen, H., Cabral-da-Silva, M. E. C., Ohtonen, S., Wojciechowski, S., Shakirzyanova, A., Caligola, S., Giugno, R., Ishchenko, Y., Hern\u00e1ndez, D., Fazaludeen, M. F., Eamen, S., Budia, M. G., Fagerlund, I., Scoyni, F., Korhonen, P., Huber, N., Haapasalo, A., Hewitt, A. W., Vickers, J., \u2026 Malm, T. (2019). Stem Cell Reports<\/em>, 13<\/em>(4), 669\u2013683.<\/p>\n\n\n\n

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis. <\/strong>Korhonen, P., Pollari, E., Kanninen, K. M., Savchenko, E., Lehtonen, \u0160., Wojciechowski, S., Pomeshchik, Y., Van Den Bosch, L., Goldsteins, G., Koistinaho, J., & Malm, T. (2019). IBRO Reports<\/em>, 6<\/em>, 74\u201386.<\/p>\n\n\n\n

Dysfunction of Cellular Proteostasis in Parkinson\u2019s Disease. <\/strong>Lehtonen, \u0160., Sonninen, T.-M., Wojciechowski, S., Goldsteins, G., & Koistinaho, J. (2019). Frontiers in Neuroscience<\/em>, 13<\/em>, 457.<\/p>\n\n\n\n

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms. <\/strong>Oksanen, M., Lehtonen, S., Jaronen, M., Goldsteins, G., H\u00e4m\u00e4l\u00e4inen, R. H., & Koistinaho, J. (2019). Cellular and Molecular Life Sciences<\/em>, 76<\/em>(14), 2739\u20132760.<\/p>\n\n\n\n

Sex-specific transcriptional and proteomic signatures in schizophrenia. <\/strong>Tiihonen, J., Koskuvi, M., Storvik, M., Hy\u00f6tyl\u00e4inen, I., Gao, Y., Puttonen, K. A., Giniatullina, R., Poguzhelskaya, E., Ojansuu, I., Vaurio, O., Cannon, T. D., L\u00f6nnqvist, J., Therman, S., Suvisaari, J., Kaprio, J., Cheng, L., Hill, A. F., L\u00e4hteenvuo, M., Tohka, J., \u2026 Koistinaho, J. (2019). Nature Communications<\/em>, 10<\/em>(1), 3933.<\/p>\n\n\n\n

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling. <\/strong>Koivum\u00e4ki, J. T., Naumenko, N., Tuomainen, T., Takalo, J., Oksanen, M., Puttonen, K. A., Lehtonen, \u0160., Kuusisto, J., Laakso, M., Koistinaho, J., & Tavi, P. (2018). Frontiers in Physiology<\/em>, 9<\/em>, 80.<\/p>\n\n\n\n

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer\u2019s disease. <\/strong>Lehtonen, \u0160., H\u00f6ytyl\u00e4inen, I., Voutilainen, J., Sonninen, T.-M., Kuusisto, J., Laakso, M., H\u00e4m\u00e4l\u00e4inen, R. H., Oksanen, M., & Koistinaho, J. (2018). Stem Cell Research<\/em>, 30<\/em>, 96\u201399.<\/p>\n\n\n\n

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer\u2019s disease patient carrying a double KM670\/671NL (Swedish) mutation in APP gene. <\/strong>Oksanen, M., Hy\u00f6tyl\u00e4inen, I., Voutilainen, J., Puttonen, K. A., H\u00e4m\u00e4l\u00e4inen, R. H., Graff, C., Lehtonen, \u0160., & Koistinaho, J. (2018). Stem Cell Research<\/em>, 31<\/em>, 181\u2013185.<\/p>\n\n\n\n

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer\u2019s Disease. <\/strong>Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, \u0160., Gubert Oliv\u00e9, M., Shakirzyanova, A., Leskel\u00e4, S., Saraj\u00e4rvi, T., Viitanen, M., Rinne, J. O., Hiltunen, M., Haapasalo, A., Giniatullin, R., Tavi, P., Zhang, S.-C., Kanninen, K. M., H\u00e4m\u00e4l\u00e4inen, R. H., & Koistinaho, J. (2017). Stem Cell Reports<\/em>, 9<\/em>(6), 1885\u20131897.<\/p>\n\n\n\n

Creation of a library of induced pluripotent stem cells from Parkinsonian patients. <\/strong>Holmqvist, S., Lehtonen, \u0160., Chumarina, M., Puttonen, K. A., Azevedo, C., Lebedeva, O., Ruponen, M., Oksanen, M., Djelloul, M., Collin, A., Goldwurm, S., Meyer, M., Lagarkova, M., Kiselev, S., Koistinaho, J., & Roybon, L. (2016). Npj Parkinson\u2019s Disease<\/em>, 2<\/em>(1), 16009.<\/p>\n\n\n\n

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP +<\/sup> Toxicity-Induced Parkinson\u2019s Disease Models.  <\/strong>Lehtonen, \u0160., Jaronen, M., Vehvil\u00e4inen, P., Lakso, M., Rudgalvyte, M., Keksa-Goldsteine, V., Wong, G., Courtney, M. J., Koistinaho, J., & Goldsteins, G. (2016) Antioxidants & Redox Signaling<\/em>, 25<\/em>(8), 485\u2013497.<\/p>\n\n\n\n

Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases.<\/strong> Lehtonen, \u0160., Lehtonen, M., & Koistinaho, J. (2016). In M. Tomizawa (Ed.), Pluripotent Stem Cells\u2014From the Bench to the Clinic<\/em>. InTech.<\/p>\n\n\n\n

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. <\/strong>Lemarchant, S., Pomeshchik, Y., Kidin, I., K\u00e4rkk\u00e4inen, V., Valonen, P., Lehtonen, S., Goldsteins, G., Malm, T., Kanninen, K., & Koistinaho, J. (2016). Molecular Neurodegeneration<\/em>, 11<\/em>(1), 10.<\/p>\n\n\n\n

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. <\/strong>Liddell, J. R., Lehtonen, S., Duncan, C., Keksa-Goldsteine, V., Levonen, A.-L., Goldsteins, G., Malm, T., White, A. R., Koistinaho, J., & Kanninen, K. M. (2016). Journal of Neuroinflammation<\/em>, 13<\/em>(1), 49.<\/p>\n\n\n\n

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. <\/strong>Korhonen, P., Kanninen, K. M., Lehtonen, \u0160., Lemarchant, S., Puttonen, K. A., Oksanen, M., Dhungana, H., Loppi, S., Pollari, E., Wojciechowski, S., Kidin, I., Garc\u00eda-Berrocoso, T., Giralt, D., Montaner, J., Koistinaho, J., & Malm, T. (2015). Brain, Behavior, and Immunity<\/em>, 49<\/em>, 322\u2013336.<\/p>\n\n\n\n

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury.  <\/strong>Pomeshchik, Y., Kidin, I., Korhonen, P., Savchenko, E., Jaronen, M., Lehtonen, S., Wojciechowski, S., Kanninen, K., Koistinaho, J., & Malm, T. (2015). Brain, Behavior, and Immunity<\/em>, 44<\/em>, 68\u201381.<\/p>\n\n\n\n

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal Cord Injury.<\/strong>  Pomeshchik, Y., Puttonen, K. A., Kidin, I., Ruponen, M., Lehtonen, S., Malm, T., \u00c5kesson, E., Hovatta, O., & Koistinaho, J. (2015). Cell Transplantation<\/em>, 24<\/em>(9), 1799\u20131812.<\/p>\n\n\n\n

Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against A<\/strong>\u03b2<\/strong> Toxicity.<\/strong>  K\u00e4rkk\u00e4inen, V., Pomeshchik, Y., Savchenko, E., Dhungana, H., Kurronen, A., Lehtonen, S., Naumenko, N., Tavi, P., Levonen, A.-L., Yamamoto, M., Malm, T., Magga, J., Kanninen, K. M., & Koistinaho, J. (2014). Stem Cells<\/em>, 32<\/em>(7), 1904\u20131916.<\/p>\n\n\n\n

Tyrosine hydroxylase gene transfections to different sites of striatum in the rat model of Parkinson\u2019s disease. <\/strong>Raasmaja, A., Lehtonen, S., K\u00e4\u00e4ri\u00e4inen, T., Lampela, P., Huotari, M., & Lecklin, A. (2013). Open Journal of Genetics<\/em>, 03<\/em>(02), 30\u201337.<\/p>\n\n\n\n

Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells. <\/strong>Huuskonen, P., Storvik, M., Kyll\u00f6nen, T., Lehtonen, S., El-Nezami, H., Auriola, S., & Pasanen, M. (2012). Toxicology Letters<\/em>, 211<\/em>, S186.<\/p>\n\n\n\n

Production of monocytic cells from bone marrow stem cells: Therapeutic usage in Alzheimer\u2019s disease.<\/strong> Magga, J., Savchenko, E., Malm, T., Rolova, T., Pollari, E., Valonen, P., Lehtonen, \u0160., Jantunen, E., Aarnio, J., Lehenkari, P., Koistinaho, M., Muona, A., & Koistinaho, J. (2012). Journal of Cellular and Molecular Medicine<\/em>, 16<\/em>(5), 1060\u20131073.<\/p>\n\n\n\n

Aflatoxin B1 \u2013 a potential endocrine disruptor \u2013 up-regulates CYP19A1 in JEG-3 cells.<\/strong> Storvik, M., Huuskonen, P., Kyll\u00f6nen, T., Lehtonen, S., El-Nezami, H., Auriola, S., & Pasanen, M. (2011). Toxicology Letters<\/em>, 202<\/em>(3), 161\u2013167.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain. Albert, K., Peltonen, S., Vanne, A., K\u00e4lv\u00e4l\u00e4, S., Syv\u00e4nen, V., Koistinaho, J., Luk, K.C., Lehtonen, \u0160. (2025) Brain, Behavior, and Immunity 130, 106097. Open access From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial […]<\/p>\n","protected":false},"author":575,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-426","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain. Albert, K., Peltonen, S., Vanne, A., K\u00e4lv\u00e4l\u00e4, S., Syv\u00e4nen, V., Koistinaho, J., Luk, K.C., Lehtonen, \u0160. (2025) Brain, Behavior, and Immunity 130, 106097. Open access From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/\" \/>\n<meta property=\"og:site_name\" content=\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-06T08:41:59+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"12 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/\",\"name\":\"Publications - Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\"},\"datePublished\":\"2021-05-17T06:35:23+00:00\",\"dateModified\":\"2025-10-06T08:41:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\",\"name\":\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications - Lehtonen lab\/ Human Brain Disease Modelling Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/","og_locale":"en_US","og_type":"article","og_title":"Publications - Lehtonen lab\/ Human Brain Disease Modelling Research Group","og_description":"Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain. Albert, K., Peltonen, S., Vanne, A., K\u00e4lv\u00e4l\u00e4, S., Syv\u00e4nen, V., Koistinaho, J., Luk, K.C., Lehtonen, \u0160. (2025) Brain, Behavior, and Immunity 130, 106097. Open access From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial […]","og_url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/","og_site_name":"Lehtonen lab\/ Human Brain Disease Modelling Research Group","article_modified_time":"2025-10-06T08:41:59+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"12 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/","url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/","name":"Publications - Lehtonen lab\/ Human Brain Disease Modelling Research Group","isPartOf":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website"},"datePublished":"2021-05-17T06:35:23+00:00","dateModified":"2025-10-06T08:41:59+00:00","breadcrumb":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/key-publications\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website","url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/","name":"Lehtonen lab\/ Human Brain Disease Modelling Research Group","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/users\/575"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/comments?post=426"}],"version-history":[{"count":1,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/426\/revisions"}],"predecessor-version":[{"id":4247,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/426\/revisions\/4247"}],"wp:attachment":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/media?parent=426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}