{"id":464,"date":"2021-05-18T11:17:16","date_gmt":"2021-05-18T08:17:16","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=464"},"modified":"2025-02-26T13:00:07","modified_gmt":"2025-02-26T11:00:07","slug":"brain-organoid","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/","title":{"rendered":"Brain organoid"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Midbrain organoids as Parkinson\u2019s disease models<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"724\" height=\"1024\" src=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-724x1024.png\" alt=\"\" class=\"wp-image-4208\" srcset=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-724x1024.png 724w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-212x300.png 212w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-768x1086.png 768w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png 827w\" sizes=\"auto, (max-width: 724px) 100vw, 724px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Publications<\/strong><\/h3>\n\n\n\n<p><strong>Sara K\u00e4lv\u00e4l\u00e4<\/strong>, Polina Abushik, Antonios Dougalis, Tarja Malm, Anssi Pelkonen, \u0160\u00e1rka Lehtonen. Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia. Preprint at bioRxiv. 2023.10.10.561672; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2023.10.10.561672\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1101\/2023.10.10.561672<\/a><\/p>\n\n\n\n<p>Albert K, <strong>K\u00e4lv\u00e4l\u00e4 S<\/strong>, Hakosalo V, Syv\u00e4nen V, Krupa P, Niskanen J, Peltonen S, Sonninen T-M, Lehtonen \u0160. Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study. Biomedicines. 2022; 10(10):2649.&nbsp;<a href=\"https:\/\/doi.org\/10.3390\/biomedicines10102649\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3390\/biomedicines10102649<\/a><\/p>\n\n\n\n<p>Albert K, Niskanen J, <strong>K\u00e4lv\u00e4l\u00e4 S<\/strong>, Lehtonen \u0160. Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia. International Journal of Molecular Sciences. 2021 Apr;22(9). <a href=\"https:\/\/doi.org\/10.3390\/ijms22094334\"><a href=\"https:\/\/doi.org\/10.3390\/ijms22094334\">https:\/\/doi.org\/10.3390\/ijms22094334<\/a><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Midbrain organoids as Parkinson\u2019s disease models Publications Sara K\u00e4lv\u00e4l\u00e4, Polina Abushik, Antonios Dougalis, Tarja Malm, Anssi Pelkonen, \u0160\u00e1rka Lehtonen. Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia. Preprint at bioRxiv. 2023.10.10.561672; doi:&nbsp;https:\/\/doi.org\/10.1101\/2023.10.10.561672 Albert K, K\u00e4lv\u00e4l\u00e4 S, Hakosalo V, Syv\u00e4nen V, Krupa P, Niskanen J, Peltonen S, Sonninen T-M, Lehtonen \u0160. [&hellip;]<\/p>\n","protected":false},"author":515,"featured_media":0,"parent":411,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-464","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"Midbrain organoids as Parkinson\u2019s disease models Publications Sara K\u00e4lv\u00e4l\u00e4, Polina Abushik, Antonios Dougalis, Tarja Malm, Anssi Pelkonen, \u0160\u00e1rka Lehtonen. Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia. Preprint at bioRxiv. 2023.10.10.561672; doi:&nbsp;https:\/\/doi.org\/10.1101\/2023.10.10.561672 Albert K, K\u00e4lv\u00e4l\u00e4 S, Hakosalo V, Syv\u00e4nen V, Krupa P, Niskanen J, Peltonen S, Sonninen T-M, Lehtonen \u0160. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/\" \/>\n<meta property=\"og:site_name\" content=\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-26T11:00:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png\" \/>\n\t<meta property=\"og:image:width\" content=\"827\" \/>\n\t<meta property=\"og:image:height\" content=\"1169\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/\",\"name\":\"Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-724x1024.png\",\"datePublished\":\"2021-05-18T08:17:16+00:00\",\"dateModified\":\"2025-02-26T11:00:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png\",\"contentUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png\",\"width\":827,\"height\":1169},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Brain organoid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\",\"name\":\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/","og_locale":"en_US","og_type":"article","og_title":"Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group","og_description":"Midbrain organoids as Parkinson\u2019s disease models Publications Sara K\u00e4lv\u00e4l\u00e4, Polina Abushik, Antonios Dougalis, Tarja Malm, Anssi Pelkonen, \u0160\u00e1rka Lehtonen. Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia. Preprint at bioRxiv. 2023.10.10.561672; doi:&nbsp;https:\/\/doi.org\/10.1101\/2023.10.10.561672 Albert K, K\u00e4lv\u00e4l\u00e4 S, Hakosalo V, Syv\u00e4nen V, Krupa P, Niskanen J, Peltonen S, Sonninen T-M, Lehtonen \u0160. [&hellip;]","og_url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/","og_site_name":"Lehtonen lab\/ Human Brain Disease Modelling Research Group","article_modified_time":"2025-02-26T11:00:07+00:00","og_image":[{"width":827,"height":1169,"url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/","url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/","name":"Brain organoid - Lehtonen lab\/ Human Brain Disease Modelling Research Group","isPartOf":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage"},"image":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage"},"thumbnailUrl":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-724x1024.png","datePublished":"2021-05-18T08:17:16+00:00","dateModified":"2025-02-26T11:00:07+00:00","breadcrumb":{"@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#primaryimage","url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png","contentUrl":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept.png","width":827,"height":1169},{"@type":"BreadcrumbList","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/brain-organoid\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/research-front\/"},{"@type":"ListItem","position":3,"name":"Brain organoid"}]},{"@type":"WebSite","@id":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website","url":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/","name":"Lehtonen lab\/ Human Brain Disease Modelling Research Group","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/users\/515"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/comments?post=464"}],"version-history":[{"count":2,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/464\/revisions"}],"predecessor-version":[{"id":4227,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/464\/revisions\/4227"}],"up":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/pages\/411"}],"wp:attachment":[{"href":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-json\/wp\/v2\/media?parent=464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}