{"id":482,"date":"2021-05-18T11:19:45","date_gmt":"2021-05-18T08:19:45","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=482"},"modified":"2025-02-26T13:01:46","modified_gmt":"2025-02-26T11:01:46","slug":"lrrk2-mutation-and-glial-cells-in-pd","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/","title":{"rendered":"Human microglia in Parkinson\u2019s disease pathology\u200b"},"content":{"rendered":"\n<p style=\"font-size:18px\">The doctoral research aims to elucidate how human microglia uptake and process aggregated alpha synuclein fibrils when exposed to inflammatory environment, modelling sporadic Parkinson\u2019s disease. Combining omics (transcriptomics, metabolomics, and lipidomics) together with functional assays (e.g. live-cell imaging, cytokine bead array) and traditional gene and protein analysis (e.g. ICC,WB, qPCR) we aim to get an multifaceted overwiew on the effects. End point is to observe the impact of microglial secretions on the wellbeing of iPSC-derived dopaminergic neurons.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"481\" src=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2-1024x481.png\" alt=\"\" class=\"wp-image-4177\" srcset=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2-1024x481.png 1024w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2-300x141.png 300w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2-768x361.png 768w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2.png 1292w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p style=\"font-size:18px\"><strong><em>Figure 1. Representative images from IFN\u03b3 immunostimulated microglia processing alpha synuclein preformed fibrils (aSyn PFFs). A. <\/em><\/strong><em>Live-imaging from the phagocytosis of ATTO-labeled aSyn PFFs. Scale bar 100\u00b5m.&nbsp; <\/em><strong><em>B. <\/em><\/strong><em>Confocal image of microglia stained with total aSyn (red) and lysosomal-associated membrane protein 1, LAMP1 (green). Scale bar 5\u00b5m.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<p><strong>Niskanen, J<\/strong>, Peltonen, S, Ohtonen, S, Fazaludeen, M.F, Luk, K.C, Giudice, L, Koistinaho, J, Malm, T, Goldsteins, G, Albert, K, Lehtonen, \u0160. 2024<strong> <\/strong>Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia. <em>GLIA<\/em>, 24626,1098-1136, <a href=\"https:\/\/doi.org\/10.1002\/glia.24626\">https:\/\/doi.org\/10.1002\/glia.24626<\/a><\/p>\n\n\n\n<p>Albert, K, K\u00e4lv\u00e4l\u00e4, S, Hakosalo, V, Syv\u00e4nen, V, Krupa, P, <strong>Niskanen, J<\/strong>, Peltonen, S, Sonninen, T.-M, Lehtonen, \u0160.<strong> <\/strong>2022 Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study. <em>Biomedicines<\/em>, 10, 2649. <a href=\"https:\/\/doi.org\/10.3390\/biomedicines10102649\">https:\/\/doi.org\/10.3390\/biomedicines10102649<\/a><\/p>\n\n\n\n<p>Albert, K, <strong>Niskanen, J<\/strong>, K\u00e4lv\u00e4l\u00e4, S, Lehtonen, \u0160. 2021 Utilising induced pluripotent stem cells in neurodegenerative disease research: focus on glia. <em>Int. J. Mol. Sci<\/em>., 22, 4334. <a href=\"https:\/\/doi.org\/10.3390\/ijms22094334\">https:\/\/doi.org\/10.3390\/ijms22094334<\/a><\/p>\n\n\n\n<p>Holmqvist\u00a0S*, Lehtonen \u0160*, Chumarina M, Puttonen KA, Azevedo C,\u00a0Lebedeva O,\u00a0Ruponen\u00a0M,\u00a0Oksanen M, Collin A,\u00a0Goldwurm\u00a0S,\u00a0Meyer M,\u00a0Lagarkova\u00a0M, Kiselev S,\u00a0Koistinaho\u00a0J,\u00a0Roybon\u00a0L.\u00a02016<strong>\u00a0<\/strong>Creation of a library of induced pluripotent stem cells from Parkinsonian patients.\u00a0<em>npj\u00a0Parkinson\u02bcs\u00a0disease<\/em>\u00a02:16009.\u00a0*\u00a0equal contribution\u00a0\u00a0\u200b <a href=\"https:\/\/doi.org\/10.1038\/npjparkd.2016.9\">https:\/\/doi.org\/10.1038\/npjparkd.2016.9<\/a><\/p>\n\n\n\n<p>\u200b<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The doctoral research aims to elucidate how human microglia uptake and process aggregated alpha synuclein fibrils when exposed to inflammatory environment, modelling sporadic Parkinson\u2019s disease. Combining omics (transcriptomics, metabolomics, and lipidomics) together with functional assays (e.g. live-cell imaging, cytokine bead array) and traditional gene and protein analysis (e.g. ICC,WB, qPCR) we aim to get an [&hellip;]<\/p>\n","protected":false},"author":575,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-482","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human microglia in Parkinson\u2019s disease pathology\u200b - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human microglia in Parkinson\u2019s disease pathology\u200b - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"The doctoral research aims to elucidate how human microglia uptake and process aggregated alpha synuclein fibrils when exposed to inflammatory environment, modelling sporadic Parkinson\u2019s disease. Combining omics (transcriptomics, metabolomics, and lipidomics) together with functional assays (e.g. live-cell imaging, cytokine bead array) and traditional gene and protein analysis (e.g. ICC,WB, qPCR) we aim to get an [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/\" \/>\n<meta property=\"og:site_name\" content=\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-26T11:01:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1292\" \/>\n\t<meta property=\"og:image:height\" content=\"607\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/\",\"name\":\"Human microglia in Parkinson\u2019s disease pathology\u200b - Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2-1024x481.png\",\"datePublished\":\"2021-05-18T08:19:45+00:00\",\"dateModified\":\"2025-02-26T11:01:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/#primaryimage\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2.png\",\"contentUrl\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/image-2.png\",\"width\":1292,\"height\":607},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Human microglia in Parkinson\u2019s disease pathology\u200b\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/#website\",\"url\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/\",\"name\":\"Lehtonen lab\/ Human Brain Disease Modelling Research Group\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Human microglia in Parkinson\u2019s disease pathology\u200b - Lehtonen lab\/ Human Brain Disease Modelling Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/lrrk2-mutation-and-glial-cells-in-pd\/","og_locale":"en_US","og_type":"article","og_title":"Human microglia in Parkinson\u2019s disease pathology\u200b - Lehtonen lab\/ Human Brain Disease Modelling Research Group","og_description":"The doctoral research aims to elucidate how human microglia uptake and process aggregated alpha synuclein fibrils when exposed to inflammatory environment, modelling sporadic Parkinson\u2019s disease. 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