{"id":590,"date":"2021-05-24T10:27:10","date_gmt":"2021-05-24T07:27:10","guid":{"rendered":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/?page_id=590"},"modified":"2025-10-06T11:27:40","modified_gmt":"2025-10-06T08:27:40","slug":"blood-brain-barrier-modelling","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/blood-brain-barrier-modelling\/","title":{"rendered":"Blood brain barrier modelling"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"888\" src=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-1024x888.jpg\" alt=\"\" class=\"wp-image-4213\" srcset=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-1024x888.jpg 1024w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-300x260.jpg 300w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-768x666.jpg 768w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-1536x1332.jpg 1536w, https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/wp-content\/uploads\/sites\/286\/2025\/02\/Concept-figure-2048x1776.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>This project aims to study the vascular dysfunction in Parkinson\u00b4s disease. First, we study the contribution of LRRK2 G2019S mutation on hiPSC-derived ECs and astrocytes. Secondly, we aim to develop a 3D model of the blood-brain barrier by using endothelial cells and astrocytes in microfluidic organ-on-chip platform. The organ-on-chip model provides a more realistic environment and allows 3D configuration of the native tissue architecture and cell-cell interactions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<p><strong>Sonninen TM<\/strong>, H\u00e4m\u00e4l\u00e4inen RH, Koskuvi M, Oksanen M, Shakirzyanova A, Wojciechowski S, et al. Metabolic alterations in Parkinson\u2019s disease astrocytes. Sci Rep. 2020 Sep 2;10(1):14474. <a href=\"https:\/\/doi.org\/10.1038\/s41598-020-71329-8\" target=\"_blank\" rel=\"noreferrer noopener\">10.1038\/s41598-020-71329-8<\/a>&nbsp;<\/p>\n\n\n\n<p><strong>Sonninen, TM<\/strong>, Peltonen, S., K\u00e4lv\u00e4l\u00e4, S., Nguyen, H.-T., Ruponen, M., Singh, P., Lehtonen, \u0160., 2025. From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells. Fluids and Barriers of the CNS 22, 58. <a href=\"https:\/\/doi.org\/10.1186\/s12987-025-00672-7\">https:\/\/doi.org\/10.1186\/s12987-025-00672-7<\/a><\/p>\n\n\n\n<p><strong>Sonninen TM<\/strong>, Peltonen S, Niskanen J, H\u00e4m\u00e4l\u00e4inen RH, Koistinaho J, Lehtonen \u0160. LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased \u03b1-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses. Int J Mol Sci. 2024 Nov 29;25(23):12874. <a href=\"https:\/\/doi.org\/10.3390\/ijms252312874\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3390\/ijms252312874<\/a>&nbsp;<\/p>\n\n\n\n<p>Wu YC, <strong>Sonninen TM<\/strong>, Peltonen S, Koistinaho J, Lehtonen \u0160. Blood\u2013Brain Barrier and Neurodegenerative Diseases\u2014Modeling with iPSC-Derived Brain Cells. Int J Mol Sci. 2021 Jul 19;22(14):7710. <a href=\"https:\/\/doi.org\/10.3390\/ijms22147710\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3390\/ijms22147710<\/a>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This project aims to study the vascular dysfunction in Parkinson\u00b4s disease. First, we study the contribution of LRRK2 G2019S mutation on hiPSC-derived ECs and astrocytes. Secondly, we aim to develop a 3D model of the blood-brain barrier by using endothelial cells and astrocytes in microfluidic organ-on-chip platform. The organ-on-chip model provides a more realistic environment [&hellip;]<\/p>\n","protected":false},"author":575,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-590","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Blood brain barrier modelling - Lehtonen lab\/ Human Brain Disease Modelling Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/human-brain-disease-modelling-group\/blood-brain-barrier-modelling\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood brain barrier modelling - Lehtonen lab\/ Human Brain Disease Modelling Research Group\" \/>\n<meta property=\"og:description\" content=\"This project aims to study the vascular dysfunction in Parkinson\u00b4s disease. First, we study the contribution of LRRK2 G2019S mutation on hiPSC-derived ECs and astrocytes. Secondly, we aim to develop a 3D model of the blood-brain barrier by using endothelial cells and astrocytes in microfluidic organ-on-chip platform. 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