Research and Publications

Esmaili H, Tajik B, Tuomainen T-P, Kurl S, Salonen JT, Virtanen JK. Associations of the serum n-6 PUFA concentrations with exercise-induced myocardial ischaemia in middle-aged and older men. British Journal of Nutrition. 2024;132(11):1522-1529. doi:10.1017/S0007114524001971. http://bit.ly/418iHrj

Virtanen J. K., & Larsson S. C. (2024). Eggs – a scoping review for Nordic Nutrition Recommendations 2023Food & Nutrition Research68. https://doi.org/10.29219/fnr.v68.10507

Zhou, B., Bennett, J. E., Wickham, A. P., Singleton, R. K., Mishra, A., Carrillo-Larco, R. M., … & Bjertness, M. B. (2024). General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7· 5 million participantsThe Lancet404(10455), 851-863. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01405-3/fulltext

Meinilä, J., & Virtanen, J. K. (2024). Meat and meat products–a scoping review for Nordic Nutrition Recommendations 2023Food & nutrition research68. https://foodandnutritionresearch.net/index.php/fnr/article/view/10538

O’Keefe, J. H., Tintle, N. L., Harris, W. S., O’Keefe, E. L., Sala-Vila, A., Attia, J., … & Mozaffarian, D. (2024). Omega-3 blood levels and stroke risk: a pooled and harmonized analysis of 183 291 participants from 29 prospective studiesStroke55(1), 50-58. https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044281

Laguzzi, F., Åkesson, A., Marklund, M., Qian, F., Gigante, B., Bartz, T. M., … & Fatty Acids and Outcomes Research Consortium (FORCE). (2024). Role of polyunsaturated fat in modifying cardiovascular risk associated with family history of cardiovascular disease: Pooled de novo results from 15 observational studiesCirculation149(4), 305-316. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065530

Phelps, N. H., Singleton, R. K., Zhou, B., Heap, R. A., Mishra, A., Bennett, J. E., … & Barbagallo, C. M. (2024). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. The Lancet403(10431), 1027-1050. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02750-2/fulltext

Ong, K. L., Marklund, M., Huang, L., Rye, K. A., Hui, N., Pan, X. F., … & Wu, J. H. (2023). Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. bmj380. https://www.bmj.com/content/380/bmj-2022-072909

Ylilauri, M. (2023). Associations of animal protein sources and dietary cholesterol and choline intakes with cognitive functioning: a prospective population-based cohort study (Doctoral dissertation, Itä-Suomen yliopisto). https://erepo.uef.fi/items/337f110c-67db-40c0-b950-8dee48734c10

Wynne-Ellis, M.M., Mursu, J.J., Tuomainen, TP. et al. Dietary fat quality and serum androgen concentrations in middle-aged men. Eur J Clin Nutr 78, 99–106 (2024). https://doi.org/10.1038/s41430-023-01358-9

Virtanen, H. (2023). Dietary protein and protein sources and the risk of chronic diseases: Associations with type 2 diabetes, coronary heart disease, heart failure and mortality among men from Eastern Finland (Doctoral dissertation, Itä-Suomen yliopisto). https://erepo.uef.fi/items/17d1c61a-ab95-474d-98cb-c941fe6a1fc8

Ari Voutilainen, Jyrki K. Virtanen, Sari Hantunen, Tarja Nurmi, Petra Kokko, Tomi-Pekka Tuomainen. Multiplicative, additive, and interactive associations of 25-hydroxyvitamin D with lung and prostate cancerInt. J. Vitam. Nutr. Res. 2024, 94(2), 133–142. https://doi.org/10.1024/0300-9831/a000780

Qian, F., Tintle, N., Jensen, P. N., Lemaitre, R. N., Imamura, F., Feldreich, T. R., … & Fatty Acids and Outcomes Research Consortium (FORCE). (2023). Omega-3 fatty acid biomarkers and incident atrial fibrillation. Journal of the American College of Cardiology82(4), 336-349. https://www.sciencedirect.com/science/article/pii/S0735109723057066?via%3Dihub

Garg, P. K., Guan, W., Nomura, S., Weir, N. L., Tintle, N., Virtanen, J. K., … & Outcomes Research Consortium. (2023). n–6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies. The American Journal of Clinical Nutrition, 118(5), 921-929. https://www.sciencedirect.com/science/article/pii/S0002916523661544?via%3Dihub

Ylilauri, M. P., & Virtanen, J. K. ARE EGGS A SUPERPOWER FOR THE BRAIN AND MEMORY?. https://kids.frontiersin.org/articles/10.3389/frym.2022.697754/full

Hockey, M., Mohebbi, M., Tolmunen, T. et al. Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional studyEur J Nutr 62, 227–237 (2023). https://doi.org/10.1007/s00394-022-02950-8

Ylilauri, M.P.T., Hantunen, S., Lönnroos, E. et al. Associations of dairy, meat, and fish intakes with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Eur J Nutr 61, 2531–2542 (2022). https://doi.org/10.1007/s00394-022-02834-x

Voutilainen, E. K., Hantunen, S., Ruusunen, A., Tuomainen, T. P., & Virtanen, J. K. (2022). Associations of fermented and non-fermented dairy consumption with serum C-reactive protein concentrations–A cross-sectional analysisClinical Nutrition ESPEN48, 401-407. https://clinicalnutritionespen.com/article/S2405-4577(22)00014-6/fulltext

Mäkelä, T. N., Tuomainen, T. P., Hantunen, S., & Virtanen, J. K. (2022). Associations of serum n–3 and n–6 polyunsaturated fatty acids with prevalence and incidence of nonalcoholic fatty liver disease. The American Journal of Clinical Nutrition116(3), 759-770. https://www.sciencedirect.com/science/article/pii/S0002916522000909?via%3Dihub

Esmaili H, Tajik B, Tuomainen T-P, Kurl S, Salonen JT, Virtanen JK. Associations of the serum n-6 PUFA with exercise cardiac power in menBritish Journal of Nutrition. 2023;129(8):1388-1397. https://doi:10.1017/S0007114522002501

Esmaili H, Tajik B, Tuomainen T-P, Kurl S, Salonen JT, Virtanen JK. Associations of the serum n-6 PUFA with exercise cardiac power in men. British Journal of Nutrition. 2023;129(8):1388-1397. doi:10.1017/S0007114522002501 https://bit.ly/4hlftWO

Kunutsor SK, Laukkanen JA, Virtanen JK. Egg and cholesterol intake, apoE4 phenotype and risk of venous thromboembolism: findings from a prospective cohort study. British Journal of Nutrition. 2023;129(2):292-300. doi:10.1017/S0007114522000988 https://bit.ly/4aJZIpX

Voutilainen, A., Brester, C., Kolehmainen, M., & Tuomainen, T. P. (2022). Epidemiological analysis of coronary heart disease and its main risk factors: are their associations multiplicative, additive, or interactive? Annals of Medicine54(1), 1500–1510. https://doi.org/10.1080/07853890.2022.2078875

Brester, C., Voutilainen, A., Tuomainen, T. P., Kauhanen, J., & Kolehmainen, M. (2022). Epidemiological predictive modeling: lessons learned from the Kuopio ischemic heart disease risk factor study. Annals of Epidemiology70, 1-8. https://www.sciencedirect.com/science/article/pii/S1047279722000448?via%3Dihub

Voutilainen, A., Virtanen, J. K., Hantunen, S., Nurmi, T., Kokko, P., & Tuomainen, T. P. (2022). How competing risks affect the epidemiological relationship between vitamin D and prostate cancer incidence? A population‐based study. Andrologia54(6), e14410. https://onlinelibrary.wiley.com/doi/10.1111/and.14410

Tajik, B., Tuomainen, T. P., Jarroch, R., Kauhanen, J., Lip, G. Y., & Isanejad, M. (2022). Lipid levels, apolipoproteins, and risk of incident atrial fibrillation in men: A report from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Journal of Clinical Lipidology16(4), 447-454. https://www.lipidjournal.com/article/S1933-2874(22)00072-1/fulltext

Tajik, B., Voutilainen, A., Kauhanen, J., Mazidi, M., Lip, G. Y., Tuomainen, T. P., & Isanejad, M. (2022). Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men: The Kuopio Ischaemic Heart Disease Risk Factor StudyLipids57(2), 141-149. https://aocs.onlinelibrary.wiley.com/doi/10.1002/lipd.12337

Hockey, M., Hoare, E., Mohebbi, M., Tolmunen, T., Hantunen, S., Tuomainen, T. P., … & Ruusunen, A. (2022). Nonfermented Dairy Intake, but Not Fermented Dairy Intake, Associated with a Higher Risk of Depression in Middle-Age and Older Finnish MenThe Journal of Nutrition152(8), 1916-1926. https://www.sciencedirect.com/science/article/pii/S0022316622007003?via%3Dihub

Voutilainen A, Virtanen JK, Hantunen S, Nurmi T, Kokko P, Tuomainen T-P. Nonoptimal Follow-up Times Make It Difficult to Detect the Epidemiological Inverse Relationship Between 25-Hydroxyvitamin D and Lung Cancer. Biostatistics Research [Internet]. 2021 Sep. 6 [cited 2025 Feb. 2];1(1):1-10. Available from: https://ojs.wiserpub.com/index.php/BSR/article/view/985

Murphy, R. A., Tintle, N., Harris, W. S., Darvishian, M., Marklund, M., Virtanen, J. K., … & Mozaffarian, D. (2022). PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE). The American journal of clinical nutrition115(3), 864-876. https://www.sciencedirect.com/science/article/pii/S0002916522105617?via%3Dihub

Setti, M. O., Kacimi, S. E. O., Niskanen, L., Virtanen, J., & Tuomainen, T. P. (2022). Synergic Interaction of Vitamin D deficiency and renal hyperfiltration on mortality in middle-aged men. Journal of Renal Nutrition, 32(6), 692-701. https://www.jrnjournal.org/article/S1051-2276(22)00009-7/abstract 

Tertsunen, H. M., Hantunen, S., Tuomainen, T. P., Salonen, J. T., & Virtanen, J. K. (2022). A healthy Nordic diet score and risk of incident CHD among men: the Kuopio Ischaemic Heart Disease Risk Factor Study.British Journal of Nutrition, 127(4), 599-606. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/healthy-nordic-diet-score-and-risk-of-incident-chd-among-men-the-kuopio-ischaemic-heart-disease-risk-factor-study/DE93B1D71054B32A2D05071C706838AB 

Harris, W. S., Tintle, N. L., Imamura, F., Qian, F., Korat, A. V. A., Marklund, M., … & Mozaffarian, D. (2021). Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nature communications,12(1), 1-9. https://www.nature.com/articles/s41467-021-22370-2 

Kraav, S. L., Lehto, S. M., Kauhanen, J., Hantunen, S., & Tolmunen, T. (2021). Loneliness and social isolation increase cancer incidence in a cohort of Finnish middle-aged men. A longitudinal study. Psychiatry research, 299, 113868. https://www.sciencedirect.com/science/article/pii/S0165178121001657?via%3Dihub

Tajik, B., Tuomainen, T. P., Isanejad, M., Salonen, J. T., & Virtanen, J. K. (2022). Serum n-6 polyunsaturated fatty acids and risk of atrial fibrillation: the Kuopio Ischaemic Heart Disease Risk Factor Study. European journal of nutrition, 61(4), 1981-1989. https://link.springer.com/article/10.1007/s00394-021-02780-0 

Taskinen, Riikka E., Sari Hantunen, Tomi-Pekka Tuomainen, and Jyrki K. Virtanen. “The associations between whole grain and refined grain intakes and serum C-reactive protein.“ European Journal of Clinical Nutrition 76, no. 4 (2022): 544-550. https://www.nature.com/articles/s41430-021-00996-1 

Zhou, B., Carrillo-Larco, R. M., Danaei, G., Riley, L. M., Paciorek, C. J., Stevens, G. A., … & Breckenkamp, J. (2021). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.The Lancet, 398(10304), 957-980. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01330-1/fulltext

Qian, F., Ardisson Korat, A. V., Imamura, F., Marklund, M., Tintle, N., Virtanen, J. K., … & Sun, Q. (2021). n-3 fatty acid biomarkers and incident type 2 diabetes: an individual participant-level pooling project of 20 prospective cohort studies. Diabetes Care, 44(5), 1133-1142. https://diabetesjournals.org/care/article/44/5/1133/138740/n-3-Fatty-Acid-Biomarkers-and-Incident-Type-2 

Virtanen, J. K., Hantunen, S.; Aina ajankohtainen D-vitamiini – uutta tietoa ihon ja aurinkosuojavoiteiden roolista. Duodecim 2020;136(22):2441-3. https://www.duodecimlehti.fi/lehti/2020/22/duo15883 

Hantunen, S., Virtanen, J.K.; D-vitamiini syövän ehkäisyssä – totta vai tarua? Duodecim 2020;136(6):601-3. https://www.duodecimlehti.fi/lehti/2020/6/duo15463 

Virtanen, J. K., Tuomainen, T. P., & Voutilainen, S. (2020). Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. European Journal of Nutrition, 59, 3857-3861. https://link.springer.com/article/10.1007/s00394-020-02223-2

Imamura, F., Fretts, A. M., Marklund, M., Ardisson Korat, A. V., Yang, W. S., Lankinen, M., … & Forouhi, N. G. (2020). Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: a pooled analysis of prospective cohort studies. PLoS medicine, 17(6), e1003102. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003102 

Tertsunen, H. M., Hantunen, S., Tuomainen, T. P., & Virtanen, J. K. (2020). Healthy Nordic diet and risk of disease death among men: the Kuopio Ischaemic Heart Disease Risk Factor Study. European Journal of nutrition, 59, 3545-3553. https://link.springer.com/article/10.1007/s00394-020-02188-2

Laine, J. T., Tuomainen, T. P., Salonen, J. T., & Virtanen, J. K. (2020). Serum copper-to-zinc-ratio and risk of incident infection in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. European journal of epidemiology, 35, 1149-1156. https://link.springer.com/article/10.1007/s10654-020-00644-1

Kraav, S. L., Awoyemi, O., Junttila, N., Vornanen, R., Kauhanen, J., Toikko, T., … & Tolmunen, T. (2021). The effects of loneliness and social isolation on all-cause, injury, cancer, and CVD mortality in a cohort of middle-aged Finnish men. A prospective study. Aging & mental health, 25(12), 2219-2228. https://www.tandfonline.com/doi/full/10.1080/13607863.2020.1830945 

Olubamwo, O. O., Virtanen, J. K., Pihlajamäki, J., & Tuomainen, T. P. (2019). Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort. BMJ Open Gastroenterology, 6(1), e000219. https://bmjopengastro.bmj.com/content/6/1/e000219 

Olubamwo, O. O., Virtanen, J. K., Pihlajamaki, J., & Tuomainen, T. P. (2019). Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study. BMJ open, 9(7), e026949. https://bmjopen.bmj.com/content/9/7/e026949 

Fretts, A. M., Imamura, F., Marklund, M., Micha, R., Wu, J. H., Murphy, R. A., … & InterAct Consortium. (2019). Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. The American journal of clinical nutrition, 109(4), 1216-1223. https://www.sciencedirect.com/science/article/pii/S0002916522031677?via%3Dihub

Ylilauri, M. P., Voutilainen, S., Lönnroos, E., Virtanen, H. E., Tuomainen, T. P., Salonen, J. T., & Virtanen, J. K. (2019). Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 110(6), 1416-1423. https://www.sciencedirect.com/science/article/pii/S0002916522013375?via%3Dihub

Marklund, M., Wu, J. H., Imamura, F., Del Gobbo, L. C., Fretts, A., De Goede, J., … & Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). (2019). Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality: an individual-level pooled analysis of 30 cohort studies. Circulation, 139(21), 2422-2436. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.038908

Virtanen, H. E., Voutilainen, S., Koskinen, T. T., Mursu, J., Kokko, P., Ylilauri, M. P., … & Virtanen, J. K. (2019). Dietary proteins and protein sources and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 109(5), 1462-1471. https://www.sciencedirect.com/science/article/pii/S0002916522031999?via%3Dihub

Abdollahi, A. M., Virtanen, H. E., Voutilainen, S., Kurl, S., Tuomainen, T. P., Salonen, J. T., & Virtanen, J. K. (2019). Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 110(1), 169-176. https://www.sciencedirect.com/science/article/pii/S0002916522011637?via%3Dihub

Olubamwo, O. O., Virtanen, J. K., Pihlajamaki, J., Mantyselka, P., & Tuomainen, T. P. (2019). Fatty liver index as a predictor of increased risk of cardiometabolic disease: finding from the Kuopio Ischaemic Heart Disease Risk Factor Study Cohort. BMJ open, 9(9), e031420. https://bmjopen.bmj.com/content/9/9/e031420

NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature569, 260–264 (2019). https://doi.org/10.1038/s41586-019-1171-x 

Tajik, B., Tuomainen, T. P., Kurl, S., Salonen, J., & Virtanen, J. K. (2019). Serum long-chain omega-3 fatty acids, hair mercury and exercise-induced myocardial ischaemia in men. Heart, 105(18), 1395-1401. https://heart.bmj.com/content/105/18/1395

“Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.” International journal of epidemiology 47, no. 3 (2018): 872-883i. https://academic.oup.com/ije/article/47/3/872/4944405?login=false 

Serviente, C., Tuomainen, T. P., Virtanen, J., Witkowski, S., Niskanen, L., & Bertone-Johnson, E. (2019). Follicle-stimulating hormone is associated with lipids in postmenopausal women. Menopause, 26(5), 540-545. https://journals.lww.com/menopausejournal/abstract/2019/05000/follicle_stimulating_hormone_is_associated_with.15.aspx 

Virtanen, H. E., Voutilainen, S., Koskinen, T. T., Mursu, J., Tuomainen, T. P., & Virtanen, J. K. (2018). Intake of different dietary proteins and risk of heart failure in men: the Kuopio Ischaemic Heart Disease risk factor study. Circulation: Heart Failure, 11(6), e004531. https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.117.004531

Koskinen, T. T., Virtanen, H. E., Voutilainen, S., Tuomainen, T. P., Mursu, J., & Virtanen, J. K. (2018). Intake of fermented and non-fermented dairy products and risk of incident CHD: the Kuopio Ischaemic Heart Disease Risk Factor Study. British Journal of Nutrition, 120(11), 1288-1297. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/intake-of-fermented-and-nonfermented-dairy-products-and-risk-of-incident-chd-the-kuopio-ischaemic-heart-disease-risk-factor-study/C074295265BE9A67E609E22F0820CA4C

Noerman, S., Kärkkäinen, O., Mattsson, A., Paananen, J., Lehtonen, M., Nurmi, T., … & Virtanen, J. K. (2019). Metabolic profiling of high egg consumption and the associated lower risk of type 2 diabetes in middle‐aged finnish men. Molecular nutrition & food research, 63(5), 1800605. https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201800605 

Lorenz, M. W., Gao, L., Ziegelbauer, K., Norata, G. D., Empana, J. P., Schmidtmann, I., … & PROG-IMT study group. (2018). Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk–Results from the PROG-IMT collaboration.PloS one, 13(4), e0191172. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191172 

Aregbesola, A., de Mello, V. D., Lindström, J., Voutilainen, S., Virtanen, J. K., Keinänen-Kiukaanniemi, S., … & Uusitupa, M. (2018). Serum adiponectin/Ferritin ratio in relation to the risk of type 2 diabetes and insulin sensitivity. Diabetes research and clinical practice, 141, 264-274. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(17)31608-X/abstract

Virtanen, J. K., Wu, J. H., Voutilainen, S., Mursu, J., & Tuomainen, T. P. (2018). Serum n–6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 107(3), 427-435. https://www.sciencedirect.com/science/article/pii/S0002916522028040?via%3Dihub

Yary, T., Virtanen, J. K., Ruusunen, A., Tuomainen, T. P., & Voutilainen, S. (2017). Association between serum zinc and later development of metabolic syndrome in middle aged and older men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Nutrition, 37, 43-47. https://www.sciencedirect.com/science/article/abs/pii/S0899900716302106?via%3Dihub 

Ylilauri, M. P., Voutilainen, S., Lönnroos, E., Mursu, J., Virtanen, H. E., Koskinen, T. T., … & Virtanen, J. K. (2017). Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study.The American Journal of Clinical Nutrition, 105(2), 476-484. https://www.sciencedirect.com/science/article/pii/S0002916522047797?via%3Dihub

Bertone-Johnson, E. R., Virtanen, J. K., Niskanen, L., Nurmi, T., Ronkainen, K., Voutilainen, S., … & Tuomainen, T. P. (2017). Association of follicle-stimulating hormone levels and risk of type 2 diabetes in older postmenopausal women. Menopause, 24(7), 796-802. https://journals.lww.com/menopausejournal/abstract/2017/07000/association_of_follicle_stimulating_hormone_levels.13.aspx

Daneshmand, R., Kurl, S., Tuomainen, T. P., & Virtanen, J. K. (2017). Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study.British Journal of Nutrition, 117(4), 582-590. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/associations-of-estimated-5desaturase-and-6desaturase-activities-with-stroke-risk-factors-and-risk-of-stroke-the-kuopio-ischaemic-heart-disease-risk-factor-study/2132DD77AF527DAAB4972115B281F5A4 

Tajik, B., Kurl, S., Tuomainen, T. P., Savonen, K., & Virtanen, J. K. (2018). Associations of the serum long-chain n-3 PUFA and hair mercury with resting heart rate, peak heart rate during exercise and heart rate recovery after exercise in middle-aged men. British Journal of Nutrition, 119(1), 66-73. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/associations-of-the-serum-longchain-n3-pufa-and-hair-mercury-with-resting-heart-rate-peak-heart-rate-during-exercise-and-heart-rate-recovery-after-exercise-in-middleaged-men/B229CEC467B3B4E7815CCE9EBDAA6969

Bertone-Johnson, E. R., Virtanen, J. K., Nurmi, T., Niskanen, L., Mursu, J., Voutilainen, S., … & Tuomainen, T. P. (2018). Follicle-stimulating hormone levels and subclinical atherosclerosis in older postmenopausal women.American Journal of Epidemiology, 187(1), 16-26. https://academic.oup.com/aje/article-abstract/187/1/16/3860089?redirectedFrom=fulltext&login=false

Virtanen, H. E., Koskinen, T. T., Voutilainen, S., Mursu, J., Tuomainen, T. P., Kokko, P., & Virtanen, J. K. (2017). Intake of different dietary proteins and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. British journal of nutrition, 117(6), 882-893. https://uef.cris.fi/en/publications/UEF-47673475

Virtanen, J. K., Giniatullin, R., Mäntyselkä, P., Voutilainen, S., Nurmi, T., Mursu, J., … & Tuomainen, T. P. (2017). Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men. Scientific Reports, 7(1), 39697. https://www.nature.com/articles/srep39697

Wu, J. H., Marklund, M., Imamura, F., Tintle, N., Korat, A. V. A., De Goede, J., … & Mozaffarian, D. (2017). Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies. The lancet Diabetes & endocrinology, 5(12), 965-974. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30307-8/abstract

Vidgren, M., Virtanen, J. K., Tolmunen, T., Nurmi, T., Tuomainen, T. P., Voutilainen, S., & Ruusunen, A. (2018). Serum concentrations of 25-hydroxyvitamin D and depression in a general middle-aged to elderly population in Finland. The Journal of nutrition, health and aging, 22(1), 159-164. https://www.sciencedirect.com/science/article/pii/S127977072302242X?via%3Dihub

Yary, T., Tolmunen, T., Lehto, S. M., Tuomainen, T. P., Nurmi, T., Kauhanen, J., … & Ruusunen, A. (2017). Serum dihomo-γ-linolenic acid level is inversely associated with the risk of depression. A 21-year follow-up study in general population men. Journal of Affective Disorders, 213, 151-155. https://www.sciencedirect.com/science/article/abs/pii/S0165032716320304?via%3Dihub 

Virtanen, J. K., Mursu, J., Voutilainen, S., & Tuomainen, T. P. (2018). The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.European journal of clinical nutrition, 72(3), 342-348. https://www.nature.com/articles/s41430-017-0009-6 

Abarca-Gómez, L., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B., Acuin, C., … & Cho, Y. (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128· 9 million children, adolescents, and adults. The lancet, 390(10113), 2627-2642. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32129-3/fulltext 

d’Ascoli, T. A., Mursu, J., Voutilainen, S., Kauhanen, J., Tuomainen, T. P., & Virtanen, J. K. (2016). Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study. European Journal of Clinical Nutrition, 70(8), 970-975. https://www.nature.com/articles/ejcn201659 

Virtanen, J. K., Mursu, J., Virtanen, H. E., Fogelholm, M., Salonen, J. T., Koskinen, T. T., … & Tuomainen, T. P. (2016). Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 103(3), 895-901. https://www.sciencedirect.com/science/article/pii/S0002916522065765?via%3Dihub 

Daneshmand, R., Kurl, S., Tuomainen, T. P., & Virtanen, J. K. (2016). Associations of serum n-3 and n-6 PUFA and hair mercury with the risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). British Journal of Nutrition, 115(10), 1851-1859. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/associations-of-serum-n3-and-n6-pufa-and-hair-mercury-with-the-risk-of-incident-stroke-in-men-the-kuopio-ischaemic-heart-disease-risk-factor-study-kihd/EDE52B6C63FC26FEABABC16E21B8BC76 

Daneshmand, R., Kurl, S., Tuomainen, T. P., & Virtanen, J. K. (2016). Associations of serum n-3 and n-6 polyunsaturated fatty acids with plasma natriuretic peptides.European Journal of Clinical Nutrition, 70(8), 963-969. https://www.nature.com/articles/ejcn201658 

Tajik, B., Kurl, S., Tuomainen, T. P., & Virtanen, J. K. (2017). Associations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury with heart rate-corrected QT and JT intervals in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. European journal of nutrition, 56, 2319-2327. https://link.springer.com/article/10.1007/s00394-016-1272-3 

Tamez, M., Virtanen, J. K., & Lajous, M. (2016). Egg consumption and risk of incident type 2 diabetes: a dose–response meta-analysis of prospective cohort studies. British Journal of Nutrition, 115(12), 2212-2218. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/egg-consumption-and-risk-of-incident-type-2-diabetes-a-doseresponse-metaanalysis-of-prospective-cohort-studies/491C61D20E03CF2DB78B685D16C33F8E 

Aregbesola, A., Voutilainen, S., Virtanen, J. K., Mursu, J., & Tuomainen, T. P. (2017). Gender difference in type 2 diabetes and the role of body iron stores. Annals of clinical biochemistry, 54(1), 113-120. https://journals.sagepub.com/doi/10.1177/0004563216646397 

Del Gobbo, L. C., Imamura, F., Aslibekyan, S., Marklund, M., Virtanen, J. K., Wennberg, M., … & Mozaffarian, D. (2016). ω-3 polyunsaturated fatty acid biomarkers and coronary heart disease: pooling project of 19 cohort studies. JAMA internal medicine, 176(8), 1155-1166. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2530286

Yary, T., Voutilainen, S., Tuomainen, T. P., Ruusunen, A., Nurmi, T., & Virtanen, J. K. (2017). Omega‐6 polyunsaturated fatty acids, serum zinc, delta‐5‐and delta‐6‐desaturase activities and incident metabolic syndrome. Journal of Human Nutrition and Dietetics, 30(4), 506-514. https://onlinelibrary.wiley.com/doi/10.1111/jhn.12437 

Nyantika, A. N., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Virtanen, J. K. (2016). Serum long-chain omega-3 polyunsaturated fatty acids and risk of orthostatic hypotension. Hypertension Research, 39(7), 543-547. https://www.nature.com/articles/hr201619 

Yary, T., Voutilainen, S., Tuomainen, T. P., Ruusunen, A., Nurmi, T., & Virtanen, J. K. (2016). Serum n–6 polyunsaturated fatty acids, Δ5-and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 103(5), 1337-1343. https://www.sciencedirect.com/science/article/pii/S0002916523119071?via%3Dihub 

Tajik, B., Kurl, S., Tuomainen, T. P., & Virtanen, J. K. (2016). The association of serum long-chain n-3 PUFA and hair mercury with exercise cardiac power in men. British Journal of Nutrition, 116(3), 487-495. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/association-of-serum-longchain-n3-pufa-and-hair-mercury-with-exercise-cardiac-power-in-men/A99A97C4026F33792C29727002207916 

NCD Risk Factor Collaboration. (2016). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19· 2 million participants. Lancet (London, England), 387(10026), 1377. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30054-X/fulltext 

Zhou, B., Bentham, J., Di Cesare, M., Bixby, H., Danaei, G., Cowan, M. J., … & Cho, B. (2017). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19· 1 million participants. The Lancet, 389(10064), 37-55. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31919-5/fulltext  

Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G., … & Gaciong, Z. (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4· 4 million participants. The lancet, 387(10027), 1513-1530. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00618-8/fulltext 

Yary, T., Lehto, S. M., Tolmunen, T., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Ruusunen, A. (2016). Dietary magnesium intake and the incidence of depression: A 20-year follow-up study. Journal of affective disorders, 193, 94-98. https://www.sciencedirect.com/science/article/abs/pii/S0165032715311824?via%3Dihub 

Virtanen, J. K. (2015). Dietary polyunsaturated fat intake in coronary heart disease risk. Clinical Lipidology and Metabolic Disorders, 10(2). https://www.tandfonline.com/doi/abs/10.2217/clp.15.5 

Danaei, G., Fahimi, S., Lu, Y., Zhou, B., Hajifathalian, K., Di Cesare, M., … & Guan, O. P. (2015). Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants. The lancet Diabetes & endocrinology, 3(8), 624-637. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00129-1/fulltext 

Virtanen, J. K., Mursu, J., Tuomainen, T. P., Virtanen, H. E., & Voutilainen, S. (2015). Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 101(5), 1088-1096. https://www.sciencedirect.com/science/article/pii/S0002916523273931?via%3Dihub 

Virtanen, J. K., Mursu, J., Tuomainen, T. P., Virtanen, H. E., & Voutilainen, S. (2015). Reply to T Kawada. The American Journal of Clinical Nutrition, 102(4), 974-975. https://www.sciencedirect.com/science/article/pii/S0002916523136896?via%3Dihub

Nyantika, A. N., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Virtanen, J. K. (2015). Serum long-chain omega-3 polyunsaturated fatty acids and future blood pressure in an ageing population. The journal of nutrition, health & aging, 19, 498-503. https://www.sciencedirect.com/science/article/pii/S127977072301360X?via%3Dihub 

Yary, T., Virtanen, J. K., Ruusunen, A., Tuomainen, T. P., & Voutilainen, S. (2016). Serum zinc and risk of type 2 diabetes incidence in men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Journal of Trace Elements in Medicine and Biology, 33, 120-124. https://www.sciencedirect.com/science/article/abs/pii/S0946672X15300420?via%3Dihub 

Mursu, J., Nurmi, T., Voutilainen, S., Tuomainen, T. P., & Virtanen, J. K. (2015). The association between serum 25-hydroxyvitamin D 3 concentration and risk of disease death in men: modification by magnesium intake. European Journal of Epidemiology, 30, 343-347. https://link.springer.com/article/10.1007/s10654-015-0006-9 

Virtanen, J. K., Mursu, J., Tuomainen, T. P., & Voutilainen, S. (2014). Dietary fatty acids and risk of coronary heart disease in men: the Kuopio Ischemic Heart Disease Risk Factor Study. Arteriosclerosis, thrombosis, and vascular biology, 34(12), 2679-2687. https://uef.cris.fi/en/publications/UEF-28981609 

Ruusunen, A., Lehto, S. M., Mursu, J., Tolmunen, T., Tuomainen, T. P., Kauhanen, J., & Voutilainen, S. (2014). Dietary patterns are associated with the prevalence of elevated depressive symptoms and the risk of getting a hospital discharge diagnosis of depression in middle-aged or older Finnish men. Journal of affective disorders, 159, 1-6. https://uef.cris.fi/en/publications/UEF-27036929 

Mursu, J., Virtanen, J. K., Tuomainen, T. P., Nurmi, T., & Voutilainen, S. (2014). Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition, 99(2), 328-333. https://uef.cris.fi/en/publications/UEF-27797702 

Lehto, S. M., Tolmunen, T., Ruusunen, A., Voutilainen, S., Tuomainen, T. P., & Kauhanen, J. (2015). Serum zinc and the risk of depression in men: observations from a 20-year follow-up study. Biological psychiatry, 77(3), e11-e12. https://www.biologicalpsychiatryjournal.com/article/S0006-3223(14)00429-6/abstract 

More studies can be found on UEF Connect page: 
https://uefconnect.uef.fi/en/kuopio-ischaemic-heart-disease-risk-factor-kihd-study-nutrition/#publications