Outcomes

Scientific Publications

Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro
Authors: Ilakya Selvarajan, Miika Kiema, Ru-Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna Kathryn Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Maximiliano Arce, Peetra U. Magnusson, Stephen White, Casey E. Romanoski, Merja Heinäniemi, Johanna P. Laakkonen, Yun Fang, Minna U. Kaikkonen
Journal: Arteriosclerosis

Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset
Authors: Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, Sander W. van der Laan
Journal: Frontiers in Genetics

Genetic variation drives differences in obesity-related gene regulation
Author: Minna U. Kaikkonen
Journal: Trends in Genetics

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease
Authors: Ling Li, Shichao Pang, Fabian Starnecker, Bertram Mueller-Myhsok, Heribert Schunkert
Journal: European Heart Journal

Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia
Authors: Valentina d’Escamard, Daniella Kadian-Dodov, Lijiang Ma, Sizhao Lu, Annette King, Yang Xu, Shouneng Peng, Bhargravi V′Gangula, Yu Zhou, Allison Thomas, Katherine C. Michelis, Emir Bander, Rihab Bouchareb, Adrien Georges, Aya Nomura-Kitabayashi, Robert J. Wiener, Kevin D. Costa, Elena Chepurko, Vadim Chepurko, Marika Fava, Temo Barwari, Anelechi Anyanwu, Farzan Filsoufi, Sander Florman, Nabila Bouatia-Naji, Lukas E. Schmidt, Manuel Mayr, Michael G. Katz, Ke Hao, Mary C. M. Weiser-Evans, Johan L. M. Björkegren, Jeffrey W. Olin, Jason C. Kovacic
Journal: Nature Cardiovascular Research

Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis
Authors: Savvina Prapiadou, Luka Živković, Barbara Thorand, Marc J. George, Sander W. van der Laan, Rainer Malik, Christian Herder, Wolfgang Koenig, Thor Ueland, Ola Kleveland, Pål Aukrust, Lars Gullestad, Jürgen Bernhagen, Gerard Pasterkamp, Annette Peters, Aroon D. Hingorani, Jonathan Rosand, Martin Dichgans, Christopher D. Anderson, Marios K. Georgakis
Journal: Circulation

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging
Authors: Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Nathalie Beaufort; Rainer Malik; Martina Schifferer; Mihail Ivilinov Todorov; Dennis Crusius; Sophie Robinson; Andree Schmidt; Jakob Körbelin; Florence Bareyre; Ali Ertürk; Christian Haass; Mikael Simons; Dominik Paquet; Stefan F. Lichtenthaler; Martin Dichgans
Journal: Nature aging

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
Authors: Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ruusalepp, Ke Hao, Seppo Ylä-Herttuala, Marika Väli, Heli Järve, Michal Mokry, Mete Civelek, Clint J. Miller, Jason C. Kovacic, Minna U. Kaikkonen, Christer Betsholtz, Johan L.M. Björkegren
Journal: Circulation Research

The Effects of FABP4 on Cardiovascular Disease in the Aging Population
Authors: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Journal: Current Atherosclerosis Reports

Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions
Authors: Tian Lan, Kaylin C.A. Palm, Luka Hoeben, Ernest Diez Benavente, R. Noah Perry, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Gerard Pasterkamp, Michal Mokry
Journal: Atherosclerosis

Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
Authors: Rainer Malik; Nathalie Beaufort; Jiang Li; Koki Tanaka; Marios K. Georgakis; Yunye He; Masaru Koido; Chikashi Terao; BioBank Japan; Christopher D. Anderson; Yoichiro Kamatani; Ramin Zand; Martin Dichgans
Journal: Nature Cardiovascular Research

Inferring histology-associated gene expression gradients in spatial transcriptomic studies
Authors: Jan Kueckelhaus, Simon Frerich, Jasim Kada-Benotmane, Christina Koupourtidou, Jovica Ninkovic, Martin Dichgans, Juergen Beck, Oliver Schnell, Dieter Henrik Heiland
Journal: Nature Communications

Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex
Authors: Christina Koupourtidou, Veronika Schwarz, Hananeh Aliee, Simon Frerich, Judith Fischer-Sternjak, Riccardo Bocchi, Tatiana Simon-Ebert, Xianshu Bai, Swetlana Sirko, Frank Kirchhoff, Martin Dichgans, Magdalena Götz, Fabian J. Theis, Jovica Ninkovic
Journal: Nature Communications

Conference attendances and presentations

ISGC workshop 2024
ESOC 2024
CNIC 2024
IVBM 2024
AHA Vascular Discovery 2024
European Atherosclerosis Society conference 2024
International Vascular Biology Meeting 2024
From Genetic Discoveries to Gene Function in Human Diseases Conference 2024