Eino Solje

Frontotemporal Lobar Degeneration
and Early Onset Dementia

Photo of research director Eino Solje

Eino Solje
Research director
Adjunct professor (docent), MD, PhD

University of Eastern Finland
Institute of Clinical Medicine / Neurology

P.O.Box 1627 (Yliopistonranta 1C)
FI-70211 Kuopio

+358 (0)40 842 5553
eino.solje (at) uef.fi
room: Ca5027

Visiting researcher, University of Brescia, Italy


  • Frontotemporal lobar degeneration
  • Neurodegenerative disorders

SUPERVISIONS (PhD students and medical students)

  • MD, PHD Kasper Katisko
  • MD Sami Heikkinen (PhD student)
  • BM Marjut Haapanen
  • BM Titta Korhonen
  • BM Annu Toivanen
  • BS Tomi Hietanen
  • LL M Kaisa Näkki
  • BM Helmi Soppela


  • Research Group Director 2019-
  • Auditor, Finnish professional education evaluation of neurology, Finnish Neurological association and University of Eastern Finland, 2018 –


  • Vice president, Finnish Young Doctors Association, 2019-
  • Representative, Finnish Medical Association, 2019-
  • Representative, Committee on medical sciences politics, Finnish Medical Association, 2018-2019
  • Chairman, Committee on future health care and medical professional tracks, Finnish Young Doctors Association, 2018-
  • Member of the board, Finnish Young Doctors Association, 2018-
  • Board member, Committee on medical specialising programs, University of Eastern Finland, 2018-
  • Vice president, Professional committee of Kuopio, Finnish Medical Association, 2017-
  • Board member, Committee on health politics, Finnish Young Doctors Association, 2016-
  • Representative in the Council, Finnish Young Doctors Association, 2015-
  • Representative, The Committee of Development and Assessment of Medical Education, School of Medicine, University of Eastern Finland, 2012-2017
  • Representative in the Faculty Council, Faculty of Health Sciences, University of Eastern Finland, 2014-2015
  • Representative in the University Collegiate Body, University of Eastern Finland, 2014-2015
  • Representative, Committee on Research and Post-Graduation Education Strategy, Faculty of Health Sciences, University of Eastern Finland, 2014
  • Representative, Committee of Curriculum Reform in Medicine, School of Medicine, University of Eastern Finland, 2013-2014



  1. Jääskeläinen O*, Solje E*, Hall A, Katisko K, Korhonen V, Tiainen M, Kangas A, Helisalmi S, Pikkarainen M, Koivisto A, Hartikainen P, Hiltunen M, Ala-Korpela M, Soininen H, Soininen P, Haapasalo A, Remes AM, Herukka SK. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients. J Alzheimers Dis. 2019;72(1).
  2. Katisko K, Cajanus A, Korhonen T, Remes AM, Haapasalo A, Solje E. Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers. Front. Neurosci. 13:658. doi: 10.3389/fnins.2019.00658. Review.
  3. Rostalski H, Leskelä S, Huber N, Katisko K, Cajanus A, Solje E, Marttinen M, Natunen T, Remes AM, Hiltunen M, Haapasalo A. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS. Front Neurosci. 2019 May 15;13:486. doi: 10.3389/fnins.2019.00486. eCollection 2019. Review.
  4. Luukkainen L, Helisalmi S, Kytövuori L, Ahmasalo R, Solje E, Haapasalo A, Hiltunen M, Remes AM, Krüger J. Mutation Analysis of the Genes Linked to Early Onset Alzheimer’s Disease and Frontotemporal Lobar Degeneration. J Alzheimers Dis. 2019;69(3):775-782. doi: 10.3233/JAD-181256.
  5. Katisko K, Kokkonen N, Krüger J, Hartikainen P, Koivisto A, Helisalmi S, Korhonen V, Tuusa J, Herukka SK, Solje E, Haapasalo A, Tasanen K, Remes AM. The Association between Frontotemporal Lobar Degeneration and Bullous Pemphigoid. J Alzheimers Dis 2018;66(2):743-750
  6. Katisko K, Solje E, Koivisto AM, Krüger J, Kinnunen T, Hartikainen P, Helisalmi S, Korhonen V, Herukka SK, Haapasalo A, Remes AM. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers. J Neuroimmunol. 2018 Aug 15;321:29-35. doi: 10.1016/j.jneuroim.2018.05.011
  7. Katisko K, Haapasalo A, Koivisto A, Krüger J, Hartikainen P, Korhonen V, Helisalmi S, Herukka SK, Remes AM, Solje E. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration J Alzheimers Dis. 2018;62(2):789-794. doi: 10.3233/JAD-170854.
  8. Solje E, Remes AM. Otsalohkodementia – neurologian ja psykiatrian rajapinnalla. Pääkirjoitus, Suomen Lääkärilehti. 2018;1-2:9 (Finnish)
  9. Cajanus A, Hall A, Koikkalainen J, Solje E, Tolonen A, Urhemaa T, Liu Y, Haanpää RM, Hartikainen P, Helisalmi S, Korhonen V, Rueckert D, Hasselbalch S, Waldemar G, Mecocci P, Vanninen R, van Gils M, Soininen H, Lötjönen J, Remes A. The Classification of Frontotemporal Lobar Degeneration According to the C9ORF72 Repeat Expansions with Novel MRI Analysis Tool Dement Geriatr Cogn Dis Extra. 2018 Feb 23;8(1):51-59. doi: 10.1159/000486849.
  10. Remes AM, Haanpää R, Suhonen N, Junttila A, Solje E. Otsalohkodementia –salakavala muistisairaus. Suomen Lääkärilehti. 2018;1-2:37-43 (Finnish)
  11. Haapalinna F, Kokki M, Jääskeläinen O, Hallikainen M, Helisalmi S, Koivisto A, Kokki H, Paajanen T, Penttinen J, Pikkarainen M, Rautiainen M, Soininen H, Solje E, Remes AM, Herukka SK. Subtle Cognitive Impairment and Alzheimer’s Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects. J Alzheimers Dis. 2018;62(1):165-174. doi: 10.3233/JAD-170534.
  12. Korhonen V, Solje E, Suhonen N, Rauramaa T, Vanninen R, Remes AM, Leinonen V. Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case. Fluids Barriers CNS. 2017 14(1):10, doi:  10.1186/s12987-017-0060-7
  13. Solje E, Riipinen P, Helisalmi S, Särkioja T, Laitinen M, Hiltunen M, Hakko H, Remes AM. The role of the FTD-ALS associated C9orf72 expansion in suicide victims. Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul 8:1-4.
  14. Haapalinna F, Paajanen T, Penttinen J, Kokki H, Kokki M, Koivisto AM, Hartikainen P, Solje E, Hänninen T, Remes AM, Herukka S-K. Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women. Dement Geriatr Cogn Dis Extra.  2016 Jul 19;6(2):303-12. doi: 10.1159/000446425.
  15. Solje E, Miettunen J, Marttila R, Helisalmi S, Laitinen M, Koivumaa-Honkanen H, Isohanni M, Hiltunen M, Jääskeläinen E, Remes AM. The C9ORF72 expansion sizes in patients with psychosis -a population based study on the Northern Finland Birth Cohort 1966. Psychiatric Genetics 2016 Apr;26(2):92-4. doi: 10.1097/YPG.0000000000000118.
  16. Natunen T, Takalo M, Kemppainen S, Marttinen M, Kurkinen KMA, Pursiheimo J, Sarajärvi T,  Viswanathan J, Gabbouj S,  Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J,  Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. Relationship between Ubiquilin-1 and BACE1 in Human Alzheimer’s Disease and APdE9 Transgenic Mouse Brain and Cell-Based Models. Neurobiology of Disease 2015 Nov;85:187-205
  17. Solje E, Aaltokallio H, Koivumaa-Honkanen H, Suhonen N, Moilanen V, Traynor B, Tienari P, Hartikainen P, Remes AM. The Phenotype of the C9ORF72 Expansion Carriers According to Revised Criteria for bvFTD, PLoS ONE 2015 10(7): e131817
  18. Solje E, Hartikainen P, Valori M, Vanninen R, Tiihonen J, Hakola P, Tienari P, Remes AM. The combination of C9ORFf72 repeat expansion and DAP12 mutation in siblings with Nasu-Hakola disease, Neurobiology of Aging 2014 Jul;35(7):1780.e13-7