Pekka Jäkälä

Cerebrovascular Disorders and Stroke Recovery / Clinical Research

Pekka Jäkälä
Professor

University of Eastern Finland
Brain Research Unit, Mediteknia
Yliopistonranta 1 B
FI-70211 Kuopio, Finland

+358-(0)44- 717 9324
pekka.jakala (at) uef.fi

Present Positions

  • Professor, Department of Neurology, UEF
  • Director, NeuroCenter Kuopio University Hospital

Academic Degrees

  • MD, Kuopio University, 1994
  • PhD, Kuopio University, 1995
  • Qualified Lecturer, Docent of Experimental Neurology, Kuopio University, 1997
  • Specialist in Neurology, Kuopio University, 2003 
  • Adjunct Professor (Docent), Neurology, Kuopio University, 2006
  • Professor, Kuopio University, 2009 –

Major Positions and Appointments

  • Researcher, Department of Neurology, Kuopio University, 1989 – 1994
  • Junior Researcher, Academy of Finland, 1995 – 1998
  • Visiting Scientist, Center for Molecular Biology (ZMBH), University of Heidelberg, 1997 – 1999
  • Resident Physician, Department of Neurology, Kuopio University Hospital, 1995 2002
  • Chief Physician of Inpatient Clinic, Department of Neurology, Kuopio University Hospital, 2003 – 2006
  • Chief Physician of Outpatient Clinic, Department of Neurology, Kuopio University Hospital, 2007 – 2009
  • Chief of Neurological Care Unit (Stroke Unit), Kuopio University Hospital, 2004 – 2009
  • Director, The Finnish Brain Research and Rehabilitation Center Neuron, 2009 – 2012
  • Professor of Neurodegenerative Diseases and Rehabilitation, UEF, 2009 – 2012
  • Director and Chief Physician, NeuroCenter, Kuopio University Hospital, 2012 – present
  • Professor of Neurology, UEF, 2012 – present

Publications

Association between Migraine and Cryptogenic Ischemic Stroke in Young Adults. Martinez-Majander N, Artto V, Ylikotila P, von Sarnowski B, Waje-Andreassen U, Yesilot N, Zedde M, Huhtakangas J, Numminen H, Jäkälä P, Fonseca AC, Redfors P, Wermer MJH, Pezzini A, Pu-taala J; SECRETO Study Group. Ann Neurol. 2020 Oct 19. doi: 10.1002/ana.25937. Online ahead of print. Ann Neurol. 2020

Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events. Onatsu J, Van-ninen R, Jäkälä P, Mustonen P, Pulkki K, Korhonen M, Hedman M, HÖglund K, Blennow K, Zetterberg H, Herukka SK, Taina M. In Vivo. 2020 Sep-Oct;34(5):2577-2586.

The selection of an optimal transportation strategy in urgent stroke missions: a simulation study. Pappinen J, Miettinen T, Laukkanen-Nevala P, Jäkälä P, Kantanen AM, Mäntyselkä P, Kurola J. Scand J Trauma Resusc Emerg Med. 2020 Jun 1;28(1):48.

Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea. Leino A, Westeren-Punnonen S, Töyräs J, Myllymaa S, Leppänen T, Ylä-Herttuala S, Muraja-Murro A, Kantanen AM, Autere J, Jäkälä P, Mervaala E, Myllymaa K. Sleep Breath. 2020 Dec;24(4):1495-1505.

Pitkänen K and Jäkälä P: Kuntoutuksen pullonkaulat. Duodecim, Aivoinfarktin teemanumero, pääkirjoitus.

Onatsu J, Vanninen R, Jäkälä P, Mustonen P, Pulkki K, Korhonen M, Hedman M, Zetterberg H, Blennow K, Höglund K, Herukka SK, Taina M: Serum Neurofilament Light Chain Concentration Correlates with Infarct Volume but Not Prognosis in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019 Aug;28(8):2242-2249.

Bornstein NM, Saver JL, Diener HC, Gorelick PB, Shuaib A, Solberg Y, Thackeray L, Savic M, Janelidze T, Zarqua N, Yarnitsky D, Molina CA; ImpACT-24B investigators: An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial. Lancet. 2019 Jul 20;394(10194):219-229.

Karhi S, Nerg O, Miettinen T, Mäkipaakkanen E, Taina M, Manninen H, Vanninen R, Jäkälä P: Mechanical Thrombectomy of Large Artery Occlusion Is Beneficial in Octogenarians. In Vivo. 2018 Sep-Oct;32(5):1223-1230.

Kantanen A-M, Nerg O, Kokkonen T, Jäkälä P: Aivoinfarktin nykyhoito – toteamisesta toimintaan! Finnanest, 2017.

Pitkänen K, Jolkkonen J, Jäkälä P: Aivoverenkiertohäiriöt ja diabetes – mitä uutta? BestPractice Neurology, 2017.

Muuronen AT, Taina M, Onatsu J, Korhonen M, Pulkki K, Jäkälä P, Vanninen R, Mustonen P: vWF correlates with visceral and pericardial adipose tissue in patients with a recent stroke of suspected cardiogenic etiology. PLoS One. 2017 Jun 1;12(6):e0178508.

Onatsu J, Taina M, Mustonen P, Hedman M, Muuronen A, Arponen O, Korhonen M, Jäkälä P, Vanninen R, Pulkki K: Soluble urokinase-type plasminogen activator receptor predicts all-cause 5-year mortality in ischemic stroke and TIA. In Vivo. 2017 31(3):381-386.

Taina M, Vanninen R, Sipola P, Muuronen A, Jäkälä P, Hedman M: Cardiac CT Differentiates Left Atrial Appendage Thrombi from Circulatory Stasis in Acute Stroke Patients. In Vivo. 2016 09-10;30(5):671-6.

Julkunen P, Määttä S, Säisänen L, Kallioniemi E, Könönen M, Jäkälä P, Vanninen R, Vaalto S: Functional and structural cortical characteristics after restricted focal motor cortical infarction evaluated at chronic stage – Indications from a preliminary study. Clin Neurophysiol. 2016 Aug;127(8):2775-84.

Pokorney SD, Piccini JP, Stevens SR, Patel MR, Pieper KS, Halperin JL, Breithardt G, Singer DE, Hankey GJ, Hacke W, Becker RC, Berkowitz SD, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Steering Committee & Investigators; ROCKET AF Steering Committee Investigators: Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF. J Am Heart Assoc. 2016 Mar 8;5(3).

Julkunen P, Könönen M, Määttä S, Tarkka IM, Hiekkala SH, Säisänen L, Vanninen R, Karhu J, Jäkälä P: Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke. Neurosci Lett. 2016 Mar 23;617:88-93.

Taina M, Rissanen V, Hedman M, Jäkälä P, Järvinen V, Vanninen R, Sipola P.: Diagnostic Performance of Left Atrial Diameter Measurement in Computed Tomography to Detect Increased Left Atrial Volume. In Vivo. 2015 Jul-Aug;29(4):487-91.

Arponen O, Muuronen A, Taina M, Sipola P, Hedman M, Jäkälä P, Vanninen R, Pulkki K, Mustonen P.: Acute phase IL-10 plasma concentration associates with the high risk sources of cardiogenic stroke. PLoS One. 2015 Apr 29;10(4).

Muuronen AT, Taina M, Hedman M, Marttila J, Kuusisto J, Onatsu J, Vanninen R, Jäkälä P, Sipola P, Mustonen P.: Increased visceral adipose tissue as a potential risk factor in patients with embolic stroke of undetermined source (ESUS). PLoS One. 2015 Mar 10;10(3).

Korhonen M, Muuronen A, Arponen O, Mustonen P, Hedman M, Jäkälä P, Vanninen R, Taina M.: Left atrial appendage morphology in patients with suspected cardiogenic stroke without known atrial fibrillation. PLoS One. 2015 Mar 9;10(3).

Lindsberg PJ, Castrén E, Korkeila J, Alho H, Erkinjuntti T, Isometsä E, Kalso E, Marttunen M, Pihko H, Tienari P, Wartiovaara A, Jäkälä P, Kälviäinen R, Soininen H, Tiihonen J, Karlsson H, Rinne J, Roine RO, Elovaara I, Tamminen T, Ohman J, Majamaa K, Hari R: Investments of research and treatment of brain diseases will pay of time. Duodecim. 2014;130(17):1721-30. Review. Finnish.

Taina M, Korhonen M, Haataja M, Muuronen A, Arponen O, Hedman M, Jäkälä P, Sipola P, Mustonen P, Vanninen R: Morphological and volumetric analysis of left atrial appendage and left atrium: cardiac computed tomography-based reproducibility assessment. PLoS One. 2014 Jul 2;9(7):e101580.

Halperin JL, Hankey GJ, Wojdyla DM, Piccini JP, Lokhnygina Y, Patel MR, Breithardt G, Singer DE, Becker RC, Hacke W, Paolini JF, Nessel CC, Mahaffey KW, Califf RM, Fox KA; ROCKET AF Steering Committee and Investigators.: Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation. 2014 Jul 8;130(2):138-46.

Effect of Middle Cerebral Artery Territory Ischemic Stroke on QT Interval. Simula S, Muuronen AT, Taina M, Jäkälä P, Sipola P, Vanninen R, Hedman M. J Stroke Cerebrovasc Dis. 2014 Apr;23(4):717-23.

Taina M, Sipola P, Muuronen A, Hedman M, Mustonen P, Kantanen AM, Jäkälä P, Vanninen R. Determinants of left atrial appendage volume in stroke patients without chronic atrial fibrillation. PLoS One. 2014 Mar 4;9(3).

Taina M, Vanninen R, Hedman M, Jäkälä P, Kärkkäinen S, Tapiola T, Sipola P. Left atrial appendage volume increased in more than half of patients with cryptogenic stroke. PLoS One. 2013 Nov 4;8(11).

Sipola P, Hedman M, Onatsu J, Turpeinen A, Halinen M, Jäkälä P, Vanninen R. Computed tomography and echocardiography together reveal more high-risk findings than echocardiography alone in the diagnostics of stroke etiology. Cerebrovasc Dis. 2013;35(6):521-30.

Jäkälä P, Jolkkonen J. Time for a neurorestorative therapy in stroke. Expert Opin Biol Ther. 2012 Mar;12(3):267-70.

Prevalence of pulmonary embolism in patients with suspected cardioembolic ischemic stroke. J Thorac Imaging. 2011 Feb;26(1):32-5.

Sipola P, Hedman M, Jäkälä P, Karjalainen AM, Peuhkurinen K, Manninen H, Vanninen R. Endovascular treatment of carotid and vertebral arteries. Ikäheimonen K, Vanninen R, Jäkälä P, Mäkinen K, Manninen H. Duodecim. 2010;126(8):945-55. Review. Finnish.

Peurala SH, Tarkka IM, Juhakoski M, Sandell K, Jäkälä P, Airaksinen O, Sivenius J. Effects of intensive therapy using gait trainer or floor walking exercises early after stroke. J. Rehab. Res., 41:166-173, 2009.

Simula S, Koivisto T, Rinne J, Vanninen R, Jäkälä P. Malignant cerebral infarction and hemicraniectomy. Duodecim. 2009;125(24):2729-38. Finnish.

Peurala SH, Tarkka IM, Juhakoski M, Könönen M, Karhu J, Jäkälä P, Vanninen R, Sivenius J. Restoration of normal cortical excitability and gait ability in acute stroke after intensive rehabilitation. Cerebrovasc Dis., 26(2):208-9; 2008.

Peurala SH, Airaksinen O, Jäkälä P, Tarkka IM, Sivenius J. Effects of intensive gait-oriented physiotherapy during early acute phase of stroke. J Rehabil Res Dev., 44(5);637-48; 2007.

Yavich L, Jäkälä P, Tanila H. Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice. J Neurochem, 99(3):724-32; 2006.

Halinen M, Jäkälä P, Sipola P, Tapiola T, Mustonen P, Kokkonen J. Cardiogenic brain embolisms. Duodecim. 2005;121(18):1961-8. Review. Finnish.