Alzheimer’s disease (AD) is usually considered disease where the nerve cells dye, the brain shrinks and the person becomes demented. However, in the critical early phase, the symptoms may be limited to selective loss of recently acquired memories, whereas general knowledge, old memories and cognitive skills may be well preserved. The key to finding an effective treatment to AD is to understand the underlying mechanisms of the key symptom of the disease, memory loss.
Our group focuses on the earliest pathophysiological steps of the disease process that is currently estimate to take 20-30 years. This is only possible with modern genetically modified disease models that recapitulate the human disease in a time-compressed and highly predictable fashion. We want to understand the consequences of molecular and cellular alternations at the level of neural networks and behavior. Besides studying the disease mechanisms we strive to find new effective interventions to stop the progression of AD.