We have carefully characterized the brain distribution of amyloid accumulation in a typical APP/PS1 mouse model and demonstrated impaired hippocampal-dependent spatial memory but intact striatal-dependent response habit learning in APP/PS1 mice
We were the first to show that amyloid accumulation is faster in female than in male APP/PS1 transgenic mice
We were the first to show that the latest AD drug memantine has beneficial cognitive effects in a transgenic AD mouse model
We have demonstrated that manipulation of dietary lipids has a major impact on cognitive functions in APP/PS1 mice
We were the first to show that hippocampal CA3 area becomes hyperactive in aged rats and perturbs the balance in the hippocampal neural network, a finding that has recently been confirmed in MCI patients
We were the second lab in the world to report that APP transgenic mice display frequent seizures and the only one that has conducted a systematic study on the in prevalence of epileptic seizures in a large APP/PS1 mouse cohort. We have also systematically characterized different subtypes of epileptiforms spikes and their regional distribution in APP/PS1 mice.
