Key publications

Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy.
J Neurosci 29: 3453-62, 2009.

Gureviciene I, Ishchenko I, Ziyatdinova S, Jin N, Lipponen A, Gurevicius K, Tanila H.  Characterization of epileptic spiking associated with brain amyloidosis in APP/PS1 mice.  Frontiers in Neurology 2019; Nov 12;10:1151.

Jin N, Lipponen A, Koivisto H, Gurevicius K, Tanila H. Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice.
Neurobiol Aging 2018; 71:127-141.

Gurevicius K, Lipponen A, Tanila H. Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer’s disease. Cerebral Cortex 2013;23(5):1148-58.

Wilson IA, Ikonen S, Gallagher M, Eichenbaum H, Tanila H. Age-associated alterations of hippocampal place cells are subregion specific.
J Neurosci 25:6877-86, 2005.

Wilson I, Gallagher M, Eichenbaum H, Tanila H. Neurocognitive Aging: prior memories hinder new hippocampal encoding.
Trends Neurosci. 29:662-70, 2006.

Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, Kaipainen S, Takalo M, Svobodová H, Leppänen L, Kemiläinen B, Ryhänen S, Kuulasmaa T, Rahunen E, Juutinen S, Mäkinen P, Miettinen P, Rauramaa T, Pihlajamäki J, Haapasalo A, Leinonen V, Tanila H*, Hiltunen M*. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. Mol Neurodeg 2020;15(1):66.

Gabbouj S. Natunen T, Koivisto H, Jokivarsi K, Takalo M, Marttinen M, Wittrahm R, Kemppainen S, Naderi R, Posado-Fernández A, Ryhänen S, Mäkinen P, Paldanius K, Doria G, Poutiainen P, Flores O, Haapasalo A, Tanila H, Hiltunen M. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.
Neurobiol Aging 2018;75:98-108.

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen H-M, Giniatullin R, Penke B,  Janáky T,  Broersen LM, Hartmann T, Tanila H. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer’s disease independent of brain amyloid deposition.
J Nutr Biochem 2014; 25(2):157-69.

Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.
Neurobiol Aging 2012; 33:1122.e23-e39.

Minkeviciene R, Banerjee P, Tanila H. Memantine improves spatial learning in a transgenic mouse model of Alzheimer’s disease. JPET 311:677-682, 2004.