{"id":143,"date":"2020-10-23T10:49:53","date_gmt":"2020-10-23T07:49:53","guid":{"rendered":"https:\/\/sites.uef.fi\/stemcellcenter\/?page_id=143"},"modified":"2024-11-15T13:39:50","modified_gmt":"2024-11-15T11:39:50","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Recent publications<\/h1>\n

Singh S, H\u00e4m\u00e4l\u00e4inen RH. The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1. Cells 2024 Jan 16;13(2):170. doi: 10.3390\/cells13020170.<\/p>\n

Singh S, Plotnikova L, Karvonen K, Ryytty S, Hypp.nen J, K.lvi.inen R, H\u00e4m\u00e4l\u00e4inen RH. Generation of a human induced pluripotent stem cell line (UEFi004-A)from a patient with Progressive Myoclonic Epilepsytype 1 (EPM1). Stem Cell Res. 2023 Nov <\/span>7;73:103248. doi: 10.1016\/j.scr.2023.103248.<\/p>\n

Ryytty S, H\u00e4m\u00e4l\u00e4inen RH. The Mitochondrial m.3243A>G Mutation on the Dish, Lessons from In Vitro Models. <\/span>Int J Mol Sci. 2023 Aug 30;24(17):13478. doi:10.3390\/ijms241713478.<\/p>\n

Ryytty S, Modi SR, Naumenko N, Shakirzyanova A, Rahman MO, Vaara M, Suomalainen A, Tavi P, H\u00e4m\u00e4l\u00e4inen RH. Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes. Cells. 2022 Aug 19;11(16):2593. doi: 10.3390\/cells11162593.<\/p>\n

Mikhailov N, H\u00e4m\u00e4l\u00e4inen RH. Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases. Ann Biomed Eng. 2022 Aug 24. doi:10.1007\/s10439-022-03051-7.<\/p>\n

Sonninen TM, H\u00e4m\u00e4l\u00e4inen RH, Koskuvi,\u00a0<\/sup>M, Saarelainen N, Oksanen M, Shakirzyanova\u00a0<\/sup>A,\u00a0Wojciechowski S, PuttonenKA,\u00a0<\/sup>Naumenko N, Goldsteins G, Laham-Karam N, Lehtonen M, Tavi P, Koistinaho J, Lehtonen \u0160.<\/em>\u00a0Metabolic alterations in Parkinson\u2019s disease astrocytes.\u00a0Scientific Reports, <\/em>2020 \u00a010(1):14474.\u00a0https:\/\/doi.org\/10.1038\/s41598-020-71329-8<\/em>\u00a0<\/em><\/strong><\/p>\n

Rolova T, Wu Y-C, Koskuvi M, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, H\u00e4m\u00e4l\u00e4inen RH,\u00a0Koistinaho J,\u00a0Lehtonen S.\u00a0Generation of a human induced pluripotent stem cell line (UEFi003-A)\u00a0carrying heterozygous\u00a0A673T\u00a0variant in amyloid precursor protein associated with a reduced risk of\u00a0Alzheimer`s disease. Stem Cell Research, <\/em>2020 14:101968, https:\/\/doi.org\/10.1016\/j.scr.2020.101968<\/a><\/p>\n

Oksanen M, Hy\u00f6tyl\u00e4inen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, Viitanen M, Levonen AL, Hovatta I, Roybon L, Kanninen KM, Lehtonen S, H\u00e4m\u00e4l\u00e4inen RH, Koistinaho J. NRF2 activation boosts antioxidant defences and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer\u2019s disease astrocytes. Glia<\/em>, 2020 Mar;68(3):589-599. doi: 10.1002\/glia.23741. https:\/\/doi.org\/10.1002\/glia.23741<\/a><\/p>\n

H\u00e4m\u00e4l\u00e4inen RH, <\/strong>Landoni JC, Ahlqvist KJ, Goffart S, Ryytty S, Rahman MO, Brilhante V, Icay K, Hautaniemi S, Wang L, Laiho M, Suomalainen A. Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias. <\/strong>Nature Metabolism, <\/em>2019 1(10), 958-965. doi: 10.1038\/s42255-019-0120-1. https:\/\/doi.org\/10.1038\/s42255-019-0120-1<\/a><\/p>\n

Oksanen\u00a0M, Lehtonen\u00a0\u0160, Jaronen M, Goldsteins G, H\u00e4m\u00e4l\u00e4inen RH, Koistinaho J. Astrocyte alterations in neurodegenerative pathologies and their modelling in human-induced pluripotent stem cell platforms.\u00a0 Cellular and Molecular Life Sciences, <\/em>2019 Jul; 76(14):2739-2760. doi: 10.1007\/s00018-019-03111-7.<\/p>\n

Oksanen\u00a0M, Hy\u00f6tyl\u00e4inen I, Voutilainen J, Puttonen KA, H\u00e4m\u00e4l\u00e4inen RH, Graff C,\u00a0Lehtonen\u00a0\u0160, Koistinaho J. Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer’s disease patient carrying a double KM670\/671NL (Swedish) mutation in APP gene. Stem Cell Res.<\/em> 2018 Aug 1;31:181-185. doi: 10.1016\/j.scr.2018.07.024.<\/p>\n

Lehtonen\u00a0\u0160, H\u00f6ytyl\u00e4inen I, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, H\u00e4m\u00e4l\u00e4inen RH,\u00a0Oksanen\u00a0M, Koistinaho J. Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer’s disease. Stem Cell Res.<\/em> 2018 Jul;30:96-99. doi:\u00a010.1016\/j.scr.2018.05.014<\/a>.<\/p>\n

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen \u0160, Gubert Oliv\u00e9 M, Shakirzyanova A, Leskel\u00e4 S, Saraj\u00e4rvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, H\u00e4m\u00e4l\u00e4inen RH, Koistinaho J. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease. Stem Cell Reports<\/em>. 2017 Dec 12;9(6):1885-1897. doi: 10.1016\/j.stemcr.2017.10.016. https:\/\/doi.org\/10.1016\/j.stemcr.2017.10.016<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Recent publications Singh S, H\u00e4m\u00e4l\u00e4inen RH. The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1. Cells 2024 Jan 16;13(2):170. doi: 10.3390\/cells13020170. Singh S, Plotnikova L, Karvonen K, Ryytty S, Hypp.nen J, K.lvi.inen R, H\u00e4m\u00e4l\u00e4inen RH. Generation of a human induced pluripotent stem cell line (UEFi004-A)from a patient […]<\/p>\n","protected":false},"author":329,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-143","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - AIVI Stem Cell Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - AIVI Stem Cell Center\" \/>\n<meta property=\"og:description\" content=\"Recent publications Singh S, H\u00e4m\u00e4l\u00e4inen RH. The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1. Cells 2024 Jan 16;13(2):170. doi: 10.3390\/cells13020170. Singh S, Plotnikova L, Karvonen K, Ryytty S, Hypp.nen J, K.lvi.inen R, H\u00e4m\u00e4l\u00e4inen RH. Generation of a human induced pluripotent stem cell line (UEFi004-A)from a patient […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/\" \/>\n<meta property=\"og:site_name\" content=\"AIVI Stem Cell Center\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-15T11:39:50+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/\",\"url\":\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/\",\"name\":\"Publications - AIVI Stem Cell Center\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/stemcellcenter\/#website\"},\"datePublished\":\"2020-10-23T07:49:53+00:00\",\"dateModified\":\"2024-11-15T11:39:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/stemcellcenter\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/stemcellcenter\/#website\",\"url\":\"https:\/\/sites.uef.fi\/stemcellcenter\/\",\"name\":\"AIVI Stem Cell Center\",\"description\":\"Pluripotent stem cell service provider\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/stemcellcenter\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications - AIVI Stem Cell Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/","og_locale":"en_US","og_type":"article","og_title":"Publications - AIVI Stem Cell Center","og_description":"Recent publications Singh S, H\u00e4m\u00e4l\u00e4inen RH. The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1. Cells 2024 Jan 16;13(2):170. doi: 10.3390\/cells13020170. Singh S, Plotnikova L, Karvonen K, Ryytty S, Hypp.nen J, K.lvi.inen R, H\u00e4m\u00e4l\u00e4inen RH. Generation of a human induced pluripotent stem cell line (UEFi004-A)from a patient […]","og_url":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/","og_site_name":"AIVI Stem Cell Center","article_modified_time":"2024-11-15T11:39:50+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/","url":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/","name":"Publications - AIVI Stem Cell Center","isPartOf":{"@id":"https:\/\/sites.uef.fi\/stemcellcenter\/#website"},"datePublished":"2020-10-23T07:49:53+00:00","dateModified":"2024-11-15T11:39:50+00:00","breadcrumb":{"@id":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.uef.fi\/stemcellcenter\/publications\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.uef.fi\/stemcellcenter\/publications\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.uef.fi\/stemcellcenter\/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https:\/\/sites.uef.fi\/stemcellcenter\/#website","url":"https:\/\/sites.uef.fi\/stemcellcenter\/","name":"AIVI Stem Cell Center","description":"Pluripotent stem cell service provider","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.uef.fi\/stemcellcenter\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/pages\/143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/users\/329"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":1,"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/pages\/143\/revisions"}],"predecessor-version":[{"id":281,"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/pages\/143\/revisions\/281"}],"wp:attachment":[{"href":"https:\/\/sites.uef.fi\/stemcellcenter\/wp-json\/wp\/v2\/media?parent=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}