{"id":1149,"date":"2022-09-15T17:58:42","date_gmt":"2022-09-15T14:58:42","guid":{"rendered":"https:\/\/sites.uef.fi\/tarja-malm-group\/?page_id=1149"},"modified":"2025-12-02T13:11:41","modified_gmt":"2025-12-02T11:11:41","slug":"ephys-core-facility","status":"publish","type":"page","link":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/","title":{"rendered":"EPHYS CORE FACILITY"},"content":{"rendered":"
IN VITRO<\/em> AND EX VIVO<\/em> ELECTROPHYSIOLOGY CORE FACILITY<\/h5>\n

Electrophysiology provides a unique way of investigating cell and tissue functionality. This is important for high quality science not only in basic cell biology and disease investigation but also in the continuously growing fields of stem cells, tissue engineering and therapy development.<\/p>\n

Our in vitro \/ ex vivo electrophysiology core facility has instrumentation for measurement of single cell electrical and functional properties, including combined fluorescence imaging and patch clamp \/ intracellular recording systems for cell cultures and tissue slices as well as multielectrode array platform for measurement of neuronal circuits. We provide services on Ca-imaging on cells and slices, patch-clamp experiments, intracellular voltage recordings, cellular and subcellular high speed confocal imaging of ions or voltage, extracellular voltage recordings (cell cultures, small tissues) and MEA measurements of network activities.<\/p>\n

We offer personal training, help and guidance for experimental planning, tissue or cell processing and data analysis. We also offer a full service package including experimental design, conduction of the measurements and the following analyses, and provide education in electrophysiology. Check for more information here<\/a>.<\/p>\n

Sample type and experiment type are sometimes very research question specific and thus need special protocols to be followed and optimized.<\/p>\n

CMOS-HD MEA<\/strong><\/span><\/p>\n

\"\"<\/p>\n

Video of tracking action potential along axons of a human iPSC-derived excitatory neuron measured using CMOS-HD MEA. Video credit: Henna J\u00e4ntti.<\/p>\n

\"\"\u00a0 \"\"<\/p>\n

\"Anssi<\/p>\n

\"\"<\/p>\n

Electrophysiology provides a unique way of investigating cell and tissue functionality. This is important for high quality science not only in basic cell biology and disease investigation but also in the continuously growing fields of stem cells, tissue engineering and therapy development.<\/p>\n

Our in vitro \/ ex vivo electrophysiology core facility has instrumentation for measurement of single cell electrical and functional properties, including combined fluorescence imaging and patch clamp \/ intracellular recording systems for cell cultures and tissue slices as well as multielectrode array platform for measurement of neuronal circuits. We provide services on Ca-imaging on cells and slices, patch-clamp experiments, intracellular voltage recordings, cellular and subcellular high speed confocal imaging of ions or voltage, extracellular voltage recordings (cell cultures, small tissues) and MEA measurements of network activities.<\/p>\n

We offer personal training, help and guidance for experimental planning, tissue or cell processing and data analysis. We also offer a full service package including experimental design, conduction of the measurements and the following analyses, and provide education in electrophysiology. You can check for more information here<\/a>.<\/p>\n

Sample type and experiment type are sometimes very research question specific and thus need special protocols to be followed and optimized.<\/p>\n\n\n

<\/p>\n\n\n\n

Instrument usage:<\/strong><\/h2>\n\n\n\n

Ca-imaging unit: 26\u20ac\/hour<\/strong><\/p>\n\n\n\n

Total hourly rate for university internal projects (from 16.00 to 08:00), cheaper evening and weekend pricing reduces the workload of day hours by 15\u20ac\/hour.<\/p>\n\n\n\n

Sales price to outsiders (incl. VAT 24%, and 24% overhead, 20% margin) 44\u20ac\/hour Consultation price for outsiders  (incl. VAT 24%, and 24% overhead, 20% margin, indirect employee costs 45%) 62\u20ac\/hour.<\/p>\n\n\n\n

Multichannel systems MEA: 10\u20ac \/hour<\/strong><\/p>\n\n\n\n

Sales price to outsiders 10\u20ac\/hour (incl. VAT 24%, and 24% overhead, 20% margin) 19\u20ac\/hour.<\/p>\n\n\n\n

Consultation price for outsiders (incl. VAT 24%, and 24% overhead, 20% margin, indirect employee costs 45%) 62\u20ac\/ hour.<\/p>\n","protected":false},"excerpt":{"rendered":"

IN VITRO AND EX VIVO ELECTROPHYSIOLOGY CORE FACILITY Electrophysiology provides a unique way of investigating cell and tissue functionality. This is important for high quality science not only in basic cell biology and disease investigation but also in the continuously growing fields of stem cells, tissue engineering and therapy development. Our in vitro \/ ex […]<\/p>\n","protected":false},"author":326,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-1149","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nEPHYS CORE FACILITY - Neuroinflammation Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EPHYS CORE FACILITY - Neuroinflammation Research Group\" \/>\n<meta property=\"og:description\" content=\"IN VITRO AND EX VIVO ELECTROPHYSIOLOGY CORE FACILITY Electrophysiology provides a unique way of investigating cell and tissue functionality. This is important for high quality science not only in basic cell biology and disease investigation but also in the continuously growing fields of stem cells, tissue engineering and therapy development. Our in vitro \/ ex […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/\" \/>\n<meta property=\"og:site_name\" content=\"Neuroinflammation Research Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-02T11:11:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif\" \/>\n\t<meta property=\"og:image:width\" content=\"512\" \/>\n\t<meta property=\"og:image:height\" content=\"554\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/gif\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/\",\"url\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/\",\"name\":\"EPHYS CORE FACILITY - Neuroinflammation Research Group\",\"isPartOf\":{\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif\",\"datePublished\":\"2022-09-15T14:58:42+00:00\",\"dateModified\":\"2025-12-02T11:11:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage\",\"url\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif\",\"contentUrl\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif\",\"width\":512,\"height\":554},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"EPHYS CORE FACILITY\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/#website\",\"url\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/\",\"name\":\"Neuroinflammation Research Group\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.uef.fi\/tarja-malm-group\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"EPHYS CORE FACILITY - Neuroinflammation Research Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/","og_locale":"en_US","og_type":"article","og_title":"EPHYS CORE FACILITY - Neuroinflammation Research Group","og_description":"IN VITRO AND EX VIVO ELECTROPHYSIOLOGY CORE FACILITY Electrophysiology provides a unique way of investigating cell and tissue functionality. This is important for high quality science not only in basic cell biology and disease investigation but also in the continuously growing fields of stem cells, tissue engineering and therapy development. Our in vitro \/ ex […]","og_url":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/","og_site_name":"Neuroinflammation Research Group","article_modified_time":"2025-12-02T11:11:41+00:00","og_image":[{"url":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif","width":512,"height":554,"type":"image\/gif"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/","url":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/","name":"EPHYS CORE FACILITY - Neuroinflammation Research Group","isPartOf":{"@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage"},"image":{"@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage"},"thumbnailUrl":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif","datePublished":"2022-09-15T14:58:42+00:00","dateModified":"2025-12-02T11:11:41+00:00","breadcrumb":{"@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#primaryimage","url":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif","contentUrl":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-content\/uploads\/sites\/202\/2025\/01\/Neuron5.gif","width":512,"height":554},{"@type":"BreadcrumbList","@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/ephys-core-facility\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.uef.fi\/tarja-malm-group\/"},{"@type":"ListItem","position":2,"name":"EPHYS CORE FACILITY"}]},{"@type":"WebSite","@id":"https:\/\/sites.uef.fi\/tarja-malm-group\/#website","url":"https:\/\/sites.uef.fi\/tarja-malm-group\/","name":"Neuroinflammation Research Group","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.uef.fi\/tarja-malm-group\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/pages\/1149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/comments?post=1149"}],"version-history":[{"count":2,"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/pages\/1149\/revisions"}],"predecessor-version":[{"id":2230,"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/pages\/1149\/revisions\/2230"}],"wp:attachment":[{"href":"https:\/\/sites.uef.fi\/tarja-malm-group\/wp-json\/wp\/v2\/media?parent=1149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}