Metabolic Phenotyping Unit

The Metabolic Phenotyping Unit provides state-of-the-art activity and energy metabolism monitoring in a metabolic cage (mice), sampling and assays for glucose and lipid metabolism, and blood pressure monitoring (mice and rats). In addition, post-mortem histopathological assessment of the liver is available.

Metabolic tests

O2, CO2, activity, food/water intake monitoring, endurance capacity

• Metabolic cages
• Treadmill
  
• Assessment of metabolism
• Glucose and insulin tolerance test
• In vivo assays for lipid metabolism: lipoprotein and chylomicron clearance, VLDL secretion, fatty acid oxidation, lipid absorption, retinol excursion
  
  Assessment of blood pressure
• Tail-cuff method

Liver ultrasound and MRI (in collaboration with Biomedical Imaging core facility at BCK

Histopathology

• Special immohistochemical stainings
• Conventional and fluorescence microscopy
• Confocal microscopy (in collaboration with Cellular Imaging Core Facility at BCK)
• Histological slide scanning (in collaboration with Biobank at Kuopio University Hospital)
• Quantitative image analysis
• Consultation for histopathology of mouse and pig cardiovascular system and liver