Selected Publications

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Selected Publications

Salminen A., Kaarniranta K., Kauppinen A. (2019) Immunosenescence: The potential role of myeloid-derived suppressor cells (MDSCs) in age-related immune deficiency. Cell Mol Life Sci, 76(10): 1901-1918. doi: 10.1007/s00018-019-03048-x

Hytti M., Korhonen E., Hyttinen JMT., Roehrich H., Kaarniranta K., Ferrington DA., Kauppinen A. (2018) Antimycin A-induced mitochondrial damage causes human RPE cell death despite activation of autophagy. Oxidat Med Cell Longev, 2019: 583656.  doi: 10.1155/2019/1583656

Korhonen E., Piippo N., Hytti M., Hyttinen JMT., Kaarniranta K., Kauppinen A. (2018) Dual role of p62/SQSTM1 in IL-1b-mediated cytokine release in human retinal pigment epithelial cells. Cytokine, 116: 70-77. doi: 10.1016/j.cyto.2018.12.015

Piippo N., Korhonen E., Hytti M., Skottman H., Kinnunen K., Josifovska N., Petrovski G., Kaarniranta K., Kauppinen A. (2018) Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome. Sci Rep, 8: 6720. doi: 10.1038/s41598-018-25123-2

Piippo N., Korhonen E., Hytti M., Kinnunen K., Kaarniranta K., Kauppinen A. (2018) Oxidative stress is the principal contributor to inflammasome activation in retinal pigment epithelium cells with defunct proteasomes and autophagy. Cell Physiol Biochem, 49: 359-367. doi: 10.1159/000492886

Arjamaa O., Aaltonen V., Piippo N., Csont T., Petrovski G., Kaarniranta K., Kauppinen A. (2017) Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol, Jun 19, doi: 10.1007/s00417-017-3711-0

Kinnunen K., Piippo N., Loukovaara S., Hytti M., Kaarniranta K., Kauppinen A. (2017) Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs). J Cell Commun Signal, 11(3): 275-279, doi: 10.1007/s12079-017-0396-4

Loukovaara S., Piippo N., Kinnunen K., Hytti M., Kaarniranta K., Kauppinen A. (2017) NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy. Acta Ophthalmol, Mar 8, doi: 10.1111/aos.13427

Kauppinen A., Paterno J., Blasiak J., Salminen A., and Kaarniranta K. (2016) Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci, 73(9): 1765-1786, doi: 10.1007/s00018-016-2147-8

Piippo N., Korkmaz A., Hytti M., Kinnunen K., Salminen A., Atalay M., Kaarniranta K., and Kauppinen A. (2014) Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. Biochim Biophys Acta, 1843(12): 3038-3046, doi: 10.1016/j.bbamcr.2014.09.015