OSTPRE

Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study – a population-based prospective cohort study-  started in 1989 – was originally aimed to investigate factors associated with bone mineral density, bone loss, falls and fractures in a target population of 14 220 peri- and postmenopausal women.

Later the scope was broadened and especially the 25-year follow-up enquiry in 2014 and 30-year follow-up enquiry in 2019 focused on physical, psychological and social factors related to healthy aging and mortality.

The unique long-term design of the study allows identification of risk and protective factors for several somatic and mental health outcomes (including some non-skeletal chronic health disorders, functional capacity and subjective wellbeing). Merging the OSTPRE questionnaire data with data from National health registers enables the validation of self-reports and broadens the scope for other important health disorders.

The OSTPRE Study Flow with additional data and major studies conducted.

Recently, the focus of the OSTPRE study is in Women´s Healthy Aging – project. This focuses on the identification of factors that predict healthy physical and psychosocial aging and low mortality. We hypothesize that functional capacity and subjective wellbeing are strongly related to healthy aging in women.

In cooperation with Kuopio University Hospital (KUH / KYS) and University of Eastern Finland, Kuopio Campus

  • University of Cambridge, UK: Addenbrooke´s Hospital
  • University of Sheffield, UK
  • University of Lund, Sweden
  • University Campus San Diego (UCSD)
  • Deakin University/ IMPACT Research Centre
  • Geelong Osteoporosis Study, University of Melbourne
  • Department of Obstetrics and Gynaecology, Kuopio University Hospital (KUH / KYS)
  • Department of Surgery, Kuopio University Hospital (KUH / KYS)
  • Department of Nuclear Medicine & Clinical Physiology, Kuopio University Hospital (KUH / KYS)
  • Department of Pulmonary Diseases, Kuopio University Hospital (KUH / KYS)
  • Research Institute of Public Health, University of Eastern Finland, Kuopio Campus
  • Department of Biochemistry, University of Eastern Finland, Kuopio Campus

OSTPRE-team members and the most important collaborators

Kröger Heikki: PI. Prof., MD, PhD. Dept. of Surgery, Orthopaedics and Traumatology, KUH, KMRU / UEF
Tuppurainen Marjo: BBA-study. Co-PI. Docent, MD, PhD. Dept. of Obstetrics and Gynaecology, KUH, KMRU / UEF
Sirola Joonas: Sarcopenia. Co–PI. Docent, MD, PhD. Dept. of Orthopaedics & Traumatology, KUH, KMRU / UEF
Honkanen Risto: Registers. Co-PI. Prof., MD, PhD, Docent, Epidemiolgist. KMRU / UEF
Rikkonen Toni: Kuopio Fall Prevention Study. Co-PI. Post-doc, MSc, PhD. KMRU / UEF, Univ. of Cambridge 2014-5
Jurvelin Jukka: BMD studies. Prof., PhD. Biophysics of Bone and Cartilage Group (BBC), UEF
Sund Reijo: Statistical methodology and national registers. Professor, KMRU / UEF and Univ. Researcher Centre for Research Methods, Dept. of Social Research, Univ. of Helsinki
Koivumaa-Honkanen Heli: SWB, depression, social psychiatry. Prof., MD, MPH. Dept. of Psychiatry, KUH, KMRU / UEF
Niskanen Leo: Endocrinology. MD, PhD, Docent. Helsinki University Hospital
Tolppanen Anna-Maija: Registers (dementia). PhD, Adj.prof. (analytic epidemiology). Research Centre for Comparative Effectiveness and Patient Safety (RECEPS), UEF
Soininen Hilkka: Neurology. Prof., MD. Dept. of Neurology, UEF
Kankaanpää Eila: Health economics. PhD, Docent. Dept. of Health and social management, UEF
Saari Juho: Well-being. Prof., PhD. Dept. of Social sciences, UEF
Tuomainen Tomi-Pekka: Atherosclerosis. Prof., MD. Epidemiology & Atherosclerosis Research Unit, UEF
Doctoral students: Ville Happonen, Aapo Talonpoika, Lauri Karttunen, Katriina Paasikallio, Sami Salo, Samu Sjöblom, Juha Suuronen, Samuli Juopperi, Henri Mononen, Sofianna Ojala, Julius Sala, Marjo Nieminen, Henri Nygren, Maria Kalliosaari, Fatemeh Alaghehband, Salla Pekonen, Yki Nordling, Muhammad Hasan, Saima Thakur, Otto Mustonen, Outi Elomaa, Mikael Hytönen, Noora Heikkinen, Aukusti Savolainen
Undergraduates: Tomi Istolainen, Miitta Vuorio, Ada Tuominen, Milla Gronoff, Viola Haapasalo, Oula Luukkonen, Anna Moilanen, Sebastian Sunnarborg, Saman Zahid

Link to OSTPRE-publications