Selected Publications

Complications After Ankle Fracture Surgery in Finland Between 1998 and 2020. Happonen V, Kröger H, Sund R. J Bone Joint Surg Am. 2024 Jul 3;106(13):1212-1220.

Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis. Mustonen AM, Palviainen M, Säisänen L, Karttunen L, Tollis S, Esrafilian A, Reijonen J, Julkunen P, Siljander PR, Kröger H, Mäki J, Arokoski J, Nieminen P. Arthritis Res Ther. 2024 Jan 22;26(1):33.

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX. Kanis JA, Johansson H, McCloskey EV, Liu E, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellström D, Merlijn T, Nordström A, Nordström P, O’Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Vandenput L, Harvey NC, Lorentzon M, Leslie WD. Osteoporos Int. 2023;34 (12):2027-2045.

How Often Do Complications and Mortality Occur After Operatively Treated Periprosthetic Proximal and Distal Femoral Fractures? A Register-based Study. Miettinen S, Sund R, Törmä S, Kröger H. Clin Orthop Relat Res. 2023; 481(10):1940-1949.

Effectiveness of exercise on fall prevention in community-dwelling older adults: a 2-year randomized controlled study of 914 women. Rikkonen T, Sund R, Koivumaa-Honkanen H, Sirola J, Honkanen R, Kröger H. Age Ageing. 2023 Apr 1;52(4) Erratum in: Age Ageing. 2023 May 1;52(5)

Comparing self-reports to national register data in the detection of disabling mental and musculoskeletal disorders among ageing women. Heikkinen J, Honkanen RJ, Williams LJ, Quirk S, Kröger H, Koivumaa-HonkanenH. Maturitas. 2022 Oct;164:46-51.

Near-Infrared Spectroscopy Enables Arthroscopic Histologic Grading of Human Knee Articular Cartilage. Sarin JK, Prakash M, Shaikh R, Torniainen J, Joukainen A, Kröger H, Afara IO, Töyräs J. Arthrosc Sports Med Rehabil. 2022 Aug 20;4(5):e1767-e1775.

Manipulation under anesthesia after total knee arthroplasty: a retrospective study of 145 patients. Sala J, Jaroma A, Sund R, Huopio J, Kröger H, Sirola J. Acta Orthop. 2022 Jun 21;93:583-587.

Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial-a randomized controlled trial. Virtanen JK, Nurmi T, Aro A, Bertone-Johnson ER, Hyppönen E, Kröger H, Lamberg-Allardt C, Manson JE, Mursu J, Mäntyselkä P, Suominen S, Uusitupa M, Voutilainen A, Tuomainen TP, Hantunen S. Am J Clin Nutr. 2022 May 1;115(5):1300-1310.

Treatment of Sciatica and Lumbar Radiculopathy with an Intervertebral Foramen Opening Protocol: Pilot Study in a Hospital Emergency and In-patient Setting. Shacklock M, Rade M, Poznic S, Marčinko A, Fredericson M, Kröger H,Kankaanpää M, Airaksinen O. Physiother Theory Pract. 2022 Mar 6:1-11. doi:10.1080/09593985.2022.2037797. Epub ahead of print. PMID: 35253599.

In vivo assessment of the passive stretching response of the bicompartmental human semitendinosus muscle using shear-wave elastography. Kositsky A, Saxby DJ, Lesch KJ, Barrett RS, Kröger H, Lahtinen O, Diamond LE, Korhonen RK, Stenroth L. J Appl Physiol (1985). 2022 Feb 1;132(2):438-447

Characteristics of Long-Term Femoral Neck Bone Loss in Postmenopausal Women: A 25-Year Follow-Up. Moilanen A, Kopra J, Kröger H, Sund R, Rikkonen T, Sirola J. J Bone Miner Res. 2022 Feb;37(2):173-178. doi: 10.1002/jbmr.4444.

Generalized Uncoupled Bone Remodeling Associated With Delayed Healing of Fatigue Fractures. Tong X, Turunen MJ, Burton IS, Kröger H. JBMR Plus. 2022 Jan 19;6(3):e10598. doi: 10.1002/jbm4.10598. PMID: 35309868; PMCID: PMC8914151.

Association between severe lumbar disc degeneration and self-reported occupational physical loading. Salo S, Hurri H, Rikkonen T, Sund R, Kröger H, Sirola J. J Occup Health. 2022 Jan;64(1):e12316. doi: 10.1002/1348-9585.12316. PMID:35084078.

Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65-72 years. Isanejad M, Tajik B, McArdle A, Tuppurainen M, Sirola J, Kröger H, Rikkonen T, Erkkilä A. Eur J Nutr. 2021 Dec 16. doi: 10.1007/s00394-021-02773-z. Epub ahead of print. PMID: 3491310

Urban RCT participants were healthier than non-participants or rural women. Vilpunaho T, Sund R, Koivumaa-Honkanen H, Honkanen R, Kröger H, Rikkonen T. J Clin Epidemiol 2021 Dec;140:44-55

Bone Histomorphometry and ¹⁸F-Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy. Aaltonen L, Koivuviita N, Seppänen M, Burton IS, Kröger H, Löyttyniemi E, Metsärinne K. Calcif Tissue Int. 2021 Jun 17. Epub ahead of print.

Survey of the specializing doctor training in orthopedics and traumatology across university hospitals in Finland. Ojala S, Kröger H, Leppilahti J, Paloneva J, Sirola J. Acta Orthop. 2021 Jun 2:1-3. 

Physical capability after total joint arthroplasty: long-term population-based follow-up study of 6,462 women. Turppo V, Sund R, Huopio J, Kröger H, Sirola J. Acta Orthop. 2021 May 12:1-6.Epub ahead of print.

Cardiovascular and musculoskeletal health disorders associate with greater decreases in physical capability in older women. Juopperi S, Sund R, Rikkonen T, Kröger H, Sirola J. BMC Musculoskelet Disord. 2021 Feb 16;22(1):192. doi:10.1186/s12891-021-04056-4. Erratum in: BMC Musculoskelet Disord. 2021 Apr 12;22(1):349.

Detecting pathological features and predicting fracture risk from dual-energy X-ray absorptiometry images using deep learning. Nissinen T, Suoranta S, Saavalainen T, Sund R, Hurskainen O, Rikkonen T,  Kröger H, Lähivaara T, Väänänen SP.  Bone Rep. 2021 Apr 24;14:101070.

Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up. Rikkonen T, Sund R, Sirola J, Honkanen R, Poole KES, Kröger H. Osteoporos Int. 2021 Apr;32(4):769-777.

Retrospective Population-Based Cohort Study of Incidence, Complications, and Survival of 202 Operatively Treated Periprosthetic Femoral Fractures. Miettinen SSA, Törmä SV, Lappalainen JM, Sund R, Kröger H. J Arthroplasty. 2021 Mar 1:S0883-5403(21)00220-5.. Epub ahead of print.

Regional and gender-specific analyses give new perspectives for secular trend in hip fracture incidence. Pekonen SR, Kopra J, Kröger H, Rikkonen T, Sund R. Osteoporos Int. 2021 Mar 12. Epub ahead of print

Early changes in osteochondral tissues in a rabbit model of post-traumatic osteoarthritis. Huang L, Riihioja I, Tanska P, Ojanen S, Palosaari S, Kröger H, Saarakkala SJ, Herzog W, Korhonen RK, Finnilä MAJ. J Orthop Res. 2021 Feb 13. Epub ahead of print.

Severe traffic injuries in the Helsinki Trauma Registry between 2009-2018. Airaksinen NK, Handolin LE, Heinänen MT. Injury, https://doi.org/10.1016/j.injury.2020.09.025

A fall in the previous 12 months predicts fracture in the subsequent 5 years in postmenopausal women. Afrin N, Sund R, Honkanen R, Koivumaa-Honkanen H, Rikkonen T, Williams L, Kröger H. Osteoporos Int. 2020 May;31(5):839-847.

Predictors of Better Long-term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-up Period. Tuomainen I, Pesonen J, Rade M, Pakarinen M, Leinonen V, Kröger H, Airaksinen O, Aalto T. Preoperative Spine (Phila Pa 1976). 2020 Jun 1;45(11):776-783.

Correlation between 18F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients. Aaltonen L, Koivuviita N, Seppänen M, Tong X, Kröger H, Löyttyniemi E, Metsärinne K. Bone. 2020 May;134:115267.

Revision hip arthroplasty using a porous tantalum acetabular component. Miettinen HJ, Miettinen SS, Kettunen JS, Jalkanen J, Kröger H. Hip Int. 2020 Apr 20:1120700020913294.

Risk factors for early readmission due to surgical complications after treatment of proximal femoral fractures – A Finnish National Database study of 68,800 patients. Yli-Kyyny TT, Sund R, Heinänen M, Malmivaara A, Kröger H. Injury. 2019 Feb;50(2):403-408.

High Postural Sway Is an Independent Risk Factor for Osteoporotic Fractures but Not for Mortality in Elderly Women. Qazi SL, Sirola J, Kröger H, Honkanen R, Isanejad M, Airaksinen O, Rikkonen T. J Bone Miner Res. 2019 May;34(5):817-824.

Near-infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy. Prakash M, Joukainen A, Torniainen J, Honkanen MKM, Rieppo L, Afara IO, Kröger H, Töyräs J, Sarin JK. Osteoarthritis Cartilage 2019 Aug;27(8):1235-1243.

Changes in Bone Histomorphometry after Kidney Transplantation. Keronen S, Martola L, Finne P, Burton IS, Kröger H, Honkanen E. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):894-903.

Drug treatments associated with Achilles tendon rupture. A case-control study involving 1118 Achilles tendon ruptures. Nyyssönen T, Lantto I, Lüthje P, Selander T, Kröger H. Scand J Med Sci Sports. 2018 Dec;28(12):2625-2629.

Role of musculoskeletal disorders in falls of postmenopausal women. Afrin N, Honkanen R, Koivumaa-Honkanen H, Sund R, Rikkonen T, Williams L, Kröger H. Osteoporos Int. 2018 Nov;29(11):2419-2426.

Whole exome sequencing in Finnish families identifies new candidate genes forosteoarthritis. Skarp S, Kämäräinen OP, Wei GH, Jakkula E, Kiviranta I, Kröger H, Auvinen J, Lehenkari P, Ala-Kokko L, Männikkö M. PLoS One. 2018 Aug 29;13(8):e0203313.

Cross-Validation of Arthroplasty Records Between Arthroplasty and Hospital Discharge Registers, Self-Reports, and Medical Records Among a Cohort of 14,220 Women. Turppo V, Sund R, Sirola J, Kröger H, Huopio J. J Arthroplasty. 2018 Dec;33(12):3649-3654.

Pulse-echo ultrasound method for detection of post-menopausal women with osteoporotic BMD. Karjalainen JP, Riekkinen O, Kröger H. Osteoporos Int. 2018 May;29(5):1193-1199.

Long-term effects of functional impairment on fracture risk and mortality in postmenopausal women. Rikkonen T, Poole K, Sirola J, Sund R, Honkanen R, Kröger H. Osteoporos Int. 2018 Sep;29(9):2111-2120.

Role of musculoskeletal disorders in falls of postmenopausal women. Afrin N, Honkanen R, Koivumaa-Honkanen H, Sund R, Rikkonen T, Williams L, Kröger H. Osteoporos Int. 2018 Jul 16. [Epub ahead of print]

Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study. Imtiaz B, Tuppurainen M, Rikkonen T, Kivipelto M, Soininen H, Kröger H, Tolppanen AM. Neurology. 2017 Mar 14;88(11):1062-1068.

Bone loss and wrist fractures after withdrawal of hormone therapy: The 15-year follow-up of the OSTPRE cohort.  Saarelainen J, Hassi S, Honkanen R, Koivumaa-Honkanen H, Sirola J, Kröger H,Komulainen MH, Tuppurainen M. Maturitas. 2016 Mar;85:49-55.

Multimorbidity predicts falls differentially according to the type of fall in postmenopausal women. Afrin N, Honkanen R, Koivumaa-Honkanen H, Lukkala P, Rikkonen T, Sirola J, Williams LJ, Kröger H.  Maturitas. 2016 Sep;91:19-24.

Effects of antidepressants on postmenopausal bone loss – A 5-year longitudinal study from the OSTPRE cohort.  Rauma PH, Honkanen RJ, Williams LJ, Tuppurainen MT, Kröger HP, Koivumaa-Honkanen H. Bone. 2016 Aug;89:25-31.

Optimal graft stiffness and pre-strain restore normal joint motion and cartilage responses in ACL reconstructed knee. Halonen KS, Mononen ME, Töyräs J, Kröger H, Joukainen A, Korhonen RK.  J  Biomech. 2016 Sep 6;49(13):2566-2576.

Dietary protein intake is associated with better physical function and muscle strength among elderly women. Isanejad M, Mursu J, Sirola J, Kröger H, Rikkonen T, Tuppurainen M, Erkkilä AT.  Br J Nutr. 2016;115(7):1291-91.

Targeted re-sequencing of linkage region on 2q21 identifies a novel functional variant for hip and knee osteoarthritis. Taipale M, Jakkula E, Kämäräinen OP, Gao P, Skarp S, Barral S, Kiviranta I,Kröger H, Ott J, Wei GH, Ala-Kokko L, Männikkö M. Osteoarthritis Cartilage. 2016;24(4):655-63

New method for point-of-care osteoporosis screening and diagnostics. Karjalainen JP, Riekkinen O, Töyräs J, Jurvelin JS, Kröger H. Osteoporos Int. 2016; 27:971-977.

Slump Test: Effect of Contralateral Knee Extension on Response Sensations in Asymptomatic Subjects and Cadaver Study. Shacklock M, Yee B, Van Hoof T, Foley R, Boddie K, Lacey E, Poley JB, Rade M, Kankaanpää M, Kröger H, Airaksinen O. Spine (Phila Pa 1976) 2016; 41 (4):E205-10.

Cortical bone histomorphometry in male femoral neck: the investigation of age-association and regional differences. Tong X, Burton IS, Isaksson H, Jurvelin JS, Kröger H. Calcif Tissue Int 2015 Apr;96(4):295-306.

Effect of one-year post-operative alendronate treatment on periprosthetic bone after total knee arthroplasty: a seven-year randomised controlled trial of 26 patients. Jaroma AV, Soininvaara TA, Kröger H. Bone Joint J. 2015 Mar;97-B(3):337-45.

Evaluation of the FRAX Model for Hip Fracture Predictions in the Population-based Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE). Sund R, Honkanen R, Johansson H, Odén A, McCloskey E, Kanis J, Kröger H. Calcif Tissue Int.2014 Jul;95(1):39-45.

WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kröger H, Cole WG, Lehesjoki AE, Nevarez L, Krakow D, Curry CJ, Cohn DH, Gibbs RA, Lee BH,  Mäkitie O. N Engl J Med. 2013 May 9;368(19):1809-16.

Bilateral femoral insufficiency fracture in a 40-year old man. Yli-Kyyny T, Tamminen I, Syri J, Venesmaa P, Kröger H. Lancet 2011 Jun 25; 377(9784):2248 (IF 33.633).

Altered bone composition in children with vertebral fracture. Tamminen I, Mäyränpää M, Turunen M, Isaksson H, Mäkitie O, Jurvelin J, Kröger HJ. Bone Miner Res. 2011 Sep; 26(9):2226-34. (IF 7.059).

Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy. Isaksson H, Turunen MJ, Rieppo L, Saarakkala S, Tamminen IS, Rieppo J, Kröger H, Jurvelin JS. J Bone Miner Res. 2010 Jun; 25(6):1360-6 (IF 7059).

Physical activity slows femoral bone loss but promotes wrist fractures in postmenopausal women – a 15 -year follow-up of ostpre study. Rikkonen T, Salovaara K, Sirola J, Kärkkäinen M, Tuppurainen M, Jurvelin J, Honkanen R, Alhava E, Kröger H. J Bone Miner Res. 2010 Nov; 25(11):2332-40 (IF 7.059).

Effect of vitamin D(3) and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial-the OSTPRE-FPS. Salovaara K, Tuppurainen M, Kärkkäinen M, Rikkonen T, Sandini L, Sirola J, Honkanen R, Alhava E, Kröger H. J Bone Miner Res. 2010 Jan 29;25(7):1487-1495 (IF 7.059)

Predictive value of BMD for hip and other fractures. Johnell O, Kanis JA, Oden A, Johansson H, De Laet C, Delmas P, Eisman JA, Fujiwara S, Kröger H, Mellstrom D, Meunier PJ, Melton LJ,3rd, O’Neill T, Pols H, Reeve J, Silman A, Tenenhouse A. J Bone Miner Res. 2005; 20(7):1185-1194 (IF 7.059).

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: A 2-y randomized trial. Cheng S, Lyytikainen A, Kröger H, Lamberg-Allardt C, Alen M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Vaananen KH, Tylavsky F. Am J Clin Nutr. 2005; 82(5):1115-26; quiz 1147-8 (IF 6.606).

Improving risk assessment: Hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European prospective osteoporosis study. Crabtree NJ, Kröger H, Martin A, Pols HA, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J. Osteoporos Int. 2002; 13(1):48-54 (IF 4.859).

Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: A prospective randomized study. Venesmaa PK, Kröger HP, Miettinen HJ, Jurvelin JS, Suomalainen OT, Alhava EM. J Bone Miner Res. 2001; 16(11):2126-2131 (IF 7.059).

The protective effect of hormone-replacement therapy on fracture risk is modulated by estrogen receptor alpha genotype in early postmenopausal women. Salmen T, Heikkinen AM, Mahonen A, Kröger H, Komulainen M, Saarikoski S, Honkanen R, Maenpaa PH. J Bone Miner Res. 2000; 15(12):2479-2486 (IF 7.059).

An allele of COL9A2 associated with intervertebral disc disease. Annunen S, Paassilta P, Lohiniva J, Perala M, Pihlajamaa T, Karppinen J, Tervonen O, Kroger H, Lahde S, Vanharanta H, Ryhanen L, Goring HH, Ott J, Prockop DJ, Ala-Kokko L. Science. 1999; 285(5426):409-412 (IF 31.377).

Prediction of fracture risk using axial bone mineral density in a perimenopausal population: A prospective study. Kröger H, Huopio J, Honkanen R, Tuppurainen M, Puntila E, Alhava E, Saarikoski S. J Bone Miner Res. 1995; 10(2):302-306 (IF 7.059).