Kuopio BIU equipment consist of three MRI scanners, a SPECT/CT and PET unit, optical, ultrasound and photo acoustic small animal imaging. For MRI most of the contemporary imaging and spectroscopy pulse sequences are available or can be implemented on request. μPET imaging is done in collaboration with Kuopio University Hospital and with its radiochemistry laboratory and cyclotron. Through this collaboration PET imaging with tailor made radiopharmaceuticals can be attained.
Kuopio Biomedical Imaging Unit houses four experimental MRI scanners operating at 7 T, 9.4 T or 11.7T:
- 9.4 T/31 cm horizontal MRI magnet (Agilent DirectDrive, VNMRj 3.1, and Bruker Biospec, PV 5.1 and 6.01) with 1H and X channels : Animals up to rabbits
- 7 T/16 cm horizontal Bruker PharmaScan (PV 5.1 and 6.01) magnet : Animals up to rats
- Vertical 9.4 T/89 mm magnet (Agilent DirectDrive, VNMRj 3.1) : Animals up to mice, tissues
- Vertical 11.7 T/20 mm magnet (Bruker MicroImaing, PV 6.0.1) with 1H and X channels : Materials, cells and tissues
Pre-clinical Hyperpolariser, HYPERMAG (from The Technical University of Denmark), with adjustable polarisation field 3.35-10.1 T and automated dissolution system capable of providing samples up to tens of ml. Situated next to 9.4 T horizontal imaging magnet.
With the Inveon Dedicated PET (Siemens) up to two rats or 4 mice can currently be imaged with PET simultaneously. The detector ring consists of lutetium oxyorthosilicate (LSO) block detectors, with 10 cm transaxial and 12.7 cm axial field-of-view and reaching 1.3 mm resolution. It is mainly used for imaging with various 18F- or 11C-labelled biomolecules.
The Flex SPECT/CT (GMI) unit combines functional imaging provided by SPECT, fused with high-resolution anatomical imaging provided by CT. SPECT/CT unit is suitable for imaging of mice, rats and rabbits with 99mTc, 111In, 123I and 125I tracers. The SPECT unit consist of two head detectors with NaI crystals resulting in matrix size 81 x 81 for a 12.5 x 12.5 cm2 field-of-view. The four different collimators include: high resolution and high sensitivity parallel low energy collimators, low energy pinhole collimators with 1.0 mm and 0.5 mm apertures (resolution up to 1 mm) for 99mTc, 123I and 125I tracers and parallel medium energy collimators for 111In.
The CT unit has a CMOS detector with 50 µm pitch and matrix size is up to 2048 x 2048 for a field-of-view of 10.7 x 10.7 cm2. The maximum voltage of X-Ray tube is 80 kV, and maximum current 1 mA.