Publications

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
Author(s): Kristin Fritsche; Andrea Ziková-Kloas; Philip Marx-Stoelting; Albert Braeuning
Published in: International Journal of Molecular Sciences 23, 2023, ISSN 1422-0067
DOI: 10.3390/ijms24032686

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
Author(s): Jukka Hakkola; Janne Hukkanen; Mikko Karpale
Published in: Cells, Vol 11, Iss 313, p 313 (2022), 2023, ISSN 2073-4409
DOI: 10.3390/cells11030313

Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations
Author(s): Khaled Abass, Olavi Pelkonen, Arja Rautio
Published in: Current Drug Metabolism, Volume 22, 2022, Page(s) 645-656, ISSN 1389-2002
DOI: 10.2174/1389200222666210701164945

Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice
Author(s): Skoda J, Dohnalova K, Chalupsky K, Stahl A, Templin M, Maixnerova J, Micuda S, Grontved L, Braeuning A, Pavek P
Published in: Biochemical pharmacology, Volume 197, 2022, Page(s) 114905-114905, ISSN 0006-2952
DOI: 10.1016/j.bcp.2021.114905

When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
Author(s): Alejandro Díaz-Holguín, Azam Rashidian, Dirk Pijnenburg, Dr. Glaucio Monteiro Ferreira, Alzbeta Stefela, Dr. Miroslav Kaspar, Prof. Eva Kudova, Prof. Antti Poso, Rinie van Beuningen, Prof. Petr Pavek, Dr. Thales Kronenberger
Published in: Chem Med Chem, 2022, ISSN 1860-7187
DOI: 10.1002/cmdc.202200556

EDTox: an R Shiny application to predict the endocrine disruption potential of compounds
Author(s): Sakhteman A, Ghosh A, Fortino V
Published in: Bioinformatics, 2022, ISSN 1367-4811
DOI: 10.1093/bioinformatics/btac045

Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice
Author(s): Brecht Attema; Aafke W.F. Janssen; Deborah Rijkers; Evert M. van Schothorst; Guido J.E.J. Hooiveld; Sander Kersten
Published in: Molecular Metabolism 7, ISSN 2212-8778
DOI: 10.1016/j.molmet.2022.101602

Genome-Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence
Author(s): Cartwright R, Franklin L, Tikkinen KAO, Kalliala I, Miotla P, Rechberger T, Offiah I, McMahon S, O’Reilly B, Lince S, Kluivers K, Post WM, Poelmans G, Palmer MR, Wessells H, Wong A, Kuh D, Kivimaki M, Kumari M, Mangino M, Spector T, Guggenheim JA, Lehne B, De Silva NMG, Evans DM, Lawlor D, Karhunen V, Männikkö M, Marczak M, Bennett PR, Khullar V, Järvelin M-R, Walley A
Published in: The Journal of urology, Volume 206, 2021, Page(s) 679-687, ISSN 0022-5347
DOI: 10.1097/ju.0000000000001822

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities
Author(s): Karine Audouze, Elias Zgheib, Khaled Abass, Asma H. Baig, Isabel Forner-Piquer, Henrik Holbech, Dries Knapen, Pim E. G. Leonards, Diana I. Lupu, Saranya Palaniswamy, Arja Rautio, Maria Sapounidou, Olwenn V. Martin
Published in: Frontiers in Toxicology, Volume 3, 2021, ISSN 2673-3080
DOI: 10.3389/ftox.2021.787017

Pilot study of exposure of the male population to organophosphate and pyrethroid pesticides in a region of high agricultural activity (Córdoba, Argentina)
Author(s): Iohanna Filippi, Natalia Bravo, Joan O. Grimalt, Mariana Butinof, Daniel Lerda, Ricardo A. Fernández, Sonia E. Muñoz, María V. Amé
Published in: Environmental Science and Pollution Research , Volume 28, 2021, Page(s) 908-953, ISSN 1614-7499
DOI: 10.1007/s11356-021-14397-1

Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study
Author(s): Xu S, Hansen S, Rautio A, Järvelin M, Abass K, Rysä J, Palaniswamy S, Huber S, Grimalt JO, Dumas P, Odland Jo
Published in: Environmental Research, Volume 204, 2021, Page(s) 111980, ISSN 0013-9351
DOI: 10.1016/j.envres.2021.1119

Metabolic profiles of socio-economic position: a multi-cohort analysis
Author(s): Oliver Robinson, Alice R Carter, Mika Ala-Korpela, Juan P Casas, Nishi Chaturvedi, Jorgen Engmann, Laura D Howe, Alun D Hughes, Marjo-Riitta Järvelin, Mika Kähönen, Ville Karhunen, Diana Kuh, Tina Shah, Yoav Ben-Shlomo, Reecha Sofat, Chung-Ho E Lau, Terho Lehtimäki, Usha Menon, Olli Raitakari, Andy Ryan, Rui Providencia, Stephanie Smith, Julie Taylor, Therese Tillin, Jorma Viikari, Andrew Wong, Aroon D Hingorani, Mika Kivimäki, Paolo Vineis
Published in: International Journal of Epidemiology, Volume 50, Issue 3, 2021, Page(s) 768-782, ISSN 0300-5771
DOI: 10.1093/ije/dyaa188

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study
Author(s): Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen
Published in: European Journal of Nutrition, Volume 60, Issue 8, 2021 Page(s) 4541-4553, 2021, ISSN 1436-6207
DOI: 10.1007/s00394-021-02606-z

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity
Author(s): Amirhossein Sakhteman, Mario Failli, Jenni Küblbeck, Anna-Liisa Levonen, Vittorio Fortino
Published in: Environmental International, Volume 156, 2021, Page(s) 106751, ISSN 0160-4120
DOI: 10.1016/j.envint.2021.106751

Activation of pregnane X receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanism
Author(s): Mikko Karpale, Aki Juhani Käräjämäki, Outi Kummu, Helena Gylling, Tuulia Hyötyläinen, Matej Oresic, Ari Tolonen, Heidi Hautajärvi, Markku J Savolainen, Mika Ala-Korpela, Janne Hukkanen, Jukka Hakkola
Published in: British Journal of Pharmacology, Volume 178, 2021, Page(s) 2461, ISSN1476-5381
DOI: 10.1111/bph.15433

Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes
Author(s): Saranya Palaniswamy S, Khaled Abass, Jaana Rysä, Jon Øyvind Odland, Joan O. Grimalt, Arja Rautio, Marjo-Riitta Järvelin
Published in: Environment International, Volume 156, 2021 Page(s) 106766, ISSN 0160-4120
DOI: 10.1016/j.envint.2021.10676

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism
Author(s): Smutny T, Hyrsova L, Braeuning A, Ingelman-Sundberg M, Pavek P
Published in: Archives of toxicology, Volume 95, 2020, Page(s) 11-25, ISSN 0340-5761
DOI: 10.1007/s00204-020-02916-x

Organic Air Quality Markers of Indoor and Outdoor PM2.5 Aerosols in Primary Schools from Barcelona
Author(s): Barend L. van Drooge, Ioar Rivas, Xavier Querol, Jordi Sunyer, Joan O. Grimalt
Published in: International Journal of Environmental Research and Public Health, Volume 17, 2020, Page(s) 3685, ISSN 1660-4601
DOI: 10.3390/ijerph17103685

Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3 % of babies
Author(s): Beaumont, R. N., Kotecha, S. J., Wood, A. R., Knight, B. A., Sebert, S., McCarthy, M. I., Hattersley, A. T., Järvelin, M. R., Timpson, N. J., Freathy, R. M., & Kotecha, S
Published in: PLoS genetics, Volume 16, 2020, Page(s) e1009191-e1009191, ISSN 1553-7390
DOI: 10.1371/journal.pgen.1009191

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
Author(s): Oliver Robinson, Marc Chadeau Hyam, Ibrahim Karaman, Rui Climaco Pinto, Mika Ala-Korpela, Evangelos Handakas, Giovanni Fiorito, He Gao, Andy Heard, Marjo‐Riitta Jarvelin, Matthew Lewis, Raha Pazoki, Silvia Polidoro, Ioanna Tzoulaki, Matthias Wielscher, Paul Elliott, Paolo Vineis
Published in: Aging Cell, Volume 19, Issue 6, 2020, ISSN 1474-9718
DOI: 10.1111/acel.13149

PXR and 4β-Hydroxycholesterol Axis and the Components of Metabolic Syndrome
Author(s): Janne Hukkanen, Jukka Hakkola
Published in: Cells, Volume 9, 2020, Page(s) 2445, ISSN 2073-4409
DOI: 10.3390/cells9112445

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Author(s): Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski
Published in: Cells, Volume 9, 2020, Page(s) 2306, ISSN 2073-4409
DOI:  10.3390/cells9102306

The EDCMET Project: Metabolic Effects of Endocrine Disruptors
Author(s): Jenni Küblbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
Published in: International Journal of Molecular Sciences, Issue 21/8, 2020, Page(s) 3021, ISSN 1422-0067
DOI: 10.3390/ijms21083021

Mother/child organophosphate and pyrethroid distributions
Author(s): Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat
Published in: Environment International, Issue 134, 2020, Page(s) 105264, ISSN 0160-4120
DOI: 10.1016/j.envint.2019.105264

Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition
Author(s): Eva Junqué, Sergi Garcia, María Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher, Joan O. Grimalt
Published in: Environmental Research, Issue 182, 2020, Page(s) 108994, ISSN 0013-9351
DOI: 10.1016/j.envres.2019.108994

Urinary cobalt and ferritin in four-years-old children
Author(s): Eva Junqué, Joan O. Grimalt, Ana Fernández-Somoano, Adonina Tardón
Published in: Environmental Research, Issue 183, 2020, Page(s) 109147, ISSN 0013-9351
DOI: 10.1016/j.envres.2020.109147

Organophosphate metabolite concentrations in maternal urine during pregnancy
Author(s): Natalia Bravo, Soraya Peralta, Joan O. Grimalt, Maria Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher
Published in: Environmental Research, Issue 182, 2020, Page(s) 109003, ISSN 0013-9351
DOI: 10.1016/j.envres.2019.109003

Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns
Author(s): Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland
Published in: Environment International, Issue 124, 2019, Page(s) 541-552, ISSN 0160-4120
DOI: 10.1016/j.envint.2019.01.049

Mother-child transfer rates of organohalogen compounds up to four years of age
Author(s): Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano
Published in: Environment International, Issue 133, 2019, Page(s) 105241, ISSN 0160-4120
DOI: 10.1016/j.envint.2019.105241