Inhalation toxicology laboratory measures a wide variety of toxicological endpoints that are relevant in the mechanisms of the air pollution related diseases. Inflammatory mediators are measured from various biological media, including cell culture medium, lavage fluids and serum. With multiplexing assays, up to 10 cytokines can be measured simultaneously from the same sample.
Different pathways of cytotoxicity are also measured with various methods. These measurements are mostly based on the use of fluorescent dyes in cell analyzer, flow cytometry and fluorescence microscopy. The toxicological analyses are complemented with the measurements of genotoxicity and oxidative stress. Altogether, these mechanisms give indication of cardiorespiratory and cancer related pathways of air pollution related diseases.
For more information, please contact Assoc. Prof. Pasi Jalava, pasi.jalava(at)uef.fi.