Transporters under Our Investigation

Endogenous solute carriers (SLCs) and ATP-binding cassette (ABC) proteins transport essential substrates, such as nutrients, hormones, neurotransmitters, metabolites, and drugs across the cell membranes and therefore, have a crucial role in substances’ distribution and disposition in the body. These transporters can also be utilized to enhance drug delivery and target drugs to specific organs, cells or cell organelles. Moreover, if transporter function or expression can be modulated in specific cells, the drug efficacy and safety could be greatly improved.

We are currently studying many transporters, how they could be utilized for targeted and improved drug delivery purposes. These include so far: