LRRK2-mutation and glial cells in Parkinson’s disease

LRRK2-mutation and glial cells in Parkinson’s disease

The doctoral research has been divided into three main aims, where first the LRRK2-microglia phenotype will be discovered, before creating more elaborate co-cultures together with astrocytes and neurons, to uncover the molecular crosstalk between the glial cells and their effect on neuronal well being.

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Sonninen, TM., Hämäläinen, R., Koskuvi, M., Saarelainen, N., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, KA., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J., Lehtonen, Š. 2020 Metabolic alterations in Parkinson’s disease astrocytes. Scientific Reports. 10(1):14474. DOI: 10.1038/s41598-020-71329-8

Oksanen, M., Lehtonen, Š., Jaronen, M., Goldstein, G., Martikainen, R., Koistinaho, J. 2019 Astrocyte alterations in neurodegenerative pathologies. Cell Mol Life Sci 76:2739-2760. DOI: 10.1007/s00018-019-03111-7

Holmqvist S*, Lehtonen Š*, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L. 2016 Creation of a library of induced pluripotent stem cells from Parkinsonian patients. npj Parkinsonʼs disease 2:16009. * equal contribution DOI: 10.1038/npjparkd.2016.9