LRRK2-mutation and glial cells in Parkinson’s disease

LRRK2-mutation and glial cells in Parkinson’s disease

The doctoral research has been divided into three main aims, where first the LRRK2-microglia phenotype will be discovered, before creating more elaborate co-cultures together with astrocytes and neurons, to uncover the molecular crosstalk between the glial cells and their effect on neuronal well being.

Rolova, T., Lehtonen, Š., Goldsteins, G., Kettunen, P., Koistinaho, J. 2021 Metabolic and immune dysfunction of glia in neurodegenerative disorders: focus on iPSC models. Stem Cells. 39(3):256-265. DOI: 10.1002/stem.3309

Sonninen, TM., Hämäläinen, R., Koskuvi, M., Saarelainen, N., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, KA., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J., Lehtonen, Š. 2020 Metabolic alterations in Parkinson’s disease astrocytes. Scientific Reports. 10(1):14474.  ​DOI: 10.1038/s41598-020-71329-8​

Oksanen, M., Lehtonen, Š., Jaronen, M., Goldstein, G., Martikainen, R., Koistinaho, J. 2019 Astrocyte alterations in neurodegenerative pathologies. Cell Mol Life Sci 76:2739-2760. DOI: 10.1007/s00018-019-03111-7

​Holmqvist S*, Lehtonen Š*, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L. 2016 Creation of a library of induced pluripotent stem cells from Parkinsonian patients. npj Parkinsonʼs disease 2:16009. * equal contribution  ​DOI: 10.1038/npjparkd.2016.9