Publications
Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis. Monikh, FA., Lehtonen, Š., Kekäläinen, J., Karkossa, I., Auriola, S., Schubert, K., Zanut, A., Leskinen, J., Bogialli, S., Guo Z., Kukkonen, J., Chen, C., Lynch, I. (2024) Nano today 59:102466.
Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces abberant phenotype in human microglia. Niskanen, J., Peltonen, S., Fazaludeen MF., Giudice, L., Luk, KC., Koistinaho, J., Malm, T., Goldsteins, G., Albert, K., Lehtonen, Š. (2024) Glia 24626, 1098-1136.
Beta-amyloid overproduction induces cerebral amyloid angiopathy-like changes in human iPSC-derived mural cells. Wu,Y-Ch., Lehtonen,Š., Trontti,K., Leinonen,V., Laakso,M., Kuusisto,J., Hovatta,I., Rolova,T., Koistinaho, J. (2024) Fluids and barriers of the CNS 21(1):78.
Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia. Orhan, F., Malwade, S., Khanlarkhani, N., Gkoga, A., Langeder, A., Jungholm, O., Koskuvi, M., Lehtonen, Š., Schwieler, L., Jardemark, K., Tiihonen, J., Koistinaho, J., Erhardt, S., Engberg, G., Samudyata, S., Sellgren, CM (2024) accepted to Am J. Psychiatry
Novel therapeutic strategies and common mechanism of neurodegenerative diseases.Lehtonen,Š. and Jolkkonen, J. (2024) Neuroprotection (editorial) https://doi.org/10.1002/nep3.52
Perspective on stem cell transplantation in brain diseases. Albert, K., Goldsteine, G., Kälvälä, S., Jolkkonen, J.,Lehtonen, Š. (2024) Translational Medicine Communications 9:22.
Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca2+]i distribution in human iPSC-derived cardiomyocytes. Naumenko, N., Koivumäki, JT., Lunko, O., Tuomainen, T., Leigh, R., Rabie, M., Laurila, J., Oksanen, M., Lehtonen, Š., Koistinaho, J. and Tavi, P. (2024) J Mol and Cell Cardiol 193: 78-87.
Induced pluripotent stem cell-derived microglia to study NLRP3 inflammasome activation in Alzheimer’s disease. Erdogan Öner, A., Dansokho, C., Koistinaho, J., Lehtonen, Š., Solakoglu, S., Heneka, MT (2024) J Ist Faculty Med 2024 DOI: 10.26650/IUITFD.1451011
The link between Amyloid β and ferroptosis pathway in Alzheimer’s disease progression. Majerníková, N., Marmolejo-Garza, A., Salinas, C., Luu, M., Zhang, Y., Trombetta-Lima, M., Tomin, T., Birner-Gruenberge, R., Lehtonen, Š., Koistinaho, J., Wolters, J., Ayton, S., den Dunnen WFA., Dolga, AM. (2024) accepted to Cell Death & Disease 15:782.
The impact of VEGF-C-induced dural lymphatic vessel growth on ischemic stroke pathology. Keuters, MH., Antilla, S., Immonen, R., Plotnikova, L., Wojciechowski, S., Lehtonen,Š., Alitalo, K., Koistinaho, J., Dhungana, H. (2024) Transl Stroke Res doi: 10.1007/s12975-024-01262-9.
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia. Spathopoulou, A., Fenkart, G., Marteau, V., Podlesnic, M., Kruszewski K., Koskuvi, M., Rethelyi, J., Apáti, A., Conti, L., Ku, M., Koal, T., Müller, U., Talmazan, R., Ojansuu, I., Vaurio, O., Lähteenvuo, M., Lehtonen, Š., Mertens, J., Günther, K., Tiihonen, J., Koistinaho, J., Trajanoski, Z., Edenhofer, F. (2024) Mol Psychiatry 29(10):3128-3140
Astrocytes regulate neuronal network burst frequency through NMDA receptors species- and donor-specifically. Räsänen, N., Tiihonen, J., Koskuvi, M., Lehtonen,Š., Jalkanen, N., Karmila, N., Weert, I., Pietiläinen, O., Koistinaho, J. (2024) Biological Psychiatry: Global Open Science 4(4):100313.
Genetic contribution to microglial activation in schizophrenia. Koskuvi, M., Pörsti, E., Hewitt, T., Räsänen, N., Wu, YC., Trontti, K., McQuade, A., Ojansuu, I., Vario, O., Cannon, T., Lönnqvist, J., Therman, S., Suvisaari, J., Kaprio, J., Blurton-Jones, M., Hovatta, I., Lähteenvuo, M., Rolova, T., Lehtonen Š., Tiihonen, J.,Koistinaho, J. (2024) Mol Psychiatry 29(9): 2622-2633.
Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease. Syvänen, V., Koistinaho, J., Lehtonen, Š.(2024) Expert Opin Drug Discov 19(5):603-616.
Particulate matter from car exhaust alters function of human iPSC-derived microglia. Jäntti, H., Jonk, S., Gomez-Budia, M., Ohtonen, S., Fagerlund, I., Fazaludeen, MF., Aakko-Saksa, P., Pebay, A., Lehtonen, Š., Koistinaho, J., Kanninen, KM., Jalava, PI., Malm, T., Korhonen, P. (2024) Part Fibre Toxicol 21(1):6.
Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling. Nguyen, H-T., Rissanen S-L., Peltokangas, M., Laakkonen, T., Ketunen, J., Barthod, L., Sivakumar, R., Palojärvi, A., Junttila, P., Talvitie, J., Bassis, M., Nickels, SL., Kälvälä, S., Lehtonen, Š., Schwamborn, JC, Mosser, S., Singh, P. (2024) Tissue Barriers doi: 10.1080/21688370.2024.2315702.
Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson’s disease related transcriptional profile and functions. Ohtonen, S., Giudice, L., Jäntti, H., Fazaludeen, F., Shakirzyanova, A., Gomez-Budia, M., Välimäki, NN., Korvenlaita, N., Fagerlund, I., Bruder, J., Renner, H., Schöler, H., Koistinaho, J., Amiry-Moghaddam, M., Savchenko, E., Roybon, L., Lehtonen, Š., Korhonen, P., Malm, T. (2023) Scientific Reports 13 (1):22118.
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase. Kettunen, P., Lesnikova, A., Räsänen, N., Ojha, R., Palmunen, L., Laakso, M., Lehtonen, Š., Kuusisto, J., Pietiläinen, O., Saber, S. H., Joensuu, M., Vapalahti, O. P., Koistinaho, J., Rolova, T., & Balistreri, G. (2023). Journal of Virology, 97(4), e00144-23.
Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction. Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., Trombetta-Lima, M., Oun, A., Hunneman, J., Chen, T., Koistinaho, J., Lehtonen, S., Kortholt, A., Wolters, J. C., Bakker, B. M., Eggen, B. J. L., Boddeke, E., & Dolga, A. (2023). Nature Communications, 14(1), 6454.
Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study. Albert, K., Kälvälä, S., Hakosalo, V., Syvänen, V., Krupa, P., Niskanen, J., Peltonen, S., Sonninen, T.-M., & Lehtonen, Š. (2022). Biomedicines, 10(10), 2649.
CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases. Goldsteins, G., Hakosalo, V., Jaronen, M., Keuters, M. H., Lehtonen, Š., & Koistinaho, J. (2022). Antioxidants, 11(2), 405.
Microglial amyloid beta clearance is driven by PIEZO1 channels. Jäntti, H., Sitnikova, V., Ishchenko, Y., Shakirzyanova, A., Giudice, L., Ugidos, I. F., Gómez-Budia, M., Korvenlaita, N., Ohtonen, S., Belaya, I., Fazaludeen, F., Mikhailov, N., Gotkiewicz, M., Ketola, K., Lehtonen, Š., Koistinaho, J., Kanninen, K. M., Hernández, D., Pébay, A., … Malm, T. (2022). Journal of Neuroinflammation, 19(1), 147
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia. Koskuvi, M., Lehtonen, Š., Trontti, K., Keuters, M., Wu, Y., Koivisto, H., Ludwig, A., Plotnikova, L., Virtanen, P. L. J., Räsänen, N., Kaipainen, S., Hyötyläinen, I., Dhungana, H., Giniatullina, R., Ojansuu, I., Vaurio, O., Cannon, T. D., Lönnqvist, J., Therman, S., … Koistinaho, J. (2022). Glia, 70(4), 650–660.
The iPSC perspective on schizophrenia. Räsänen, N., Tiihonen, J., Koskuvi, M., Lehtonen, Š., & Koistinaho, J. (2022). Trends in Neurosciences, 45(1), 8–26.
Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice. Välimäki, N.-N., Bakreen, A., Häkli, S., Dhungana, H., Keuters, M. H., Dunlop, Y., Koskuvi, M., Keksa-Goldsteine, V., Oksanen, M., Jäntti, H., Lehtonen, Š., Malm, T., Koistinaho, J., & Jolkkonen, J. (2022). Stroke, 53(10), 3192–3201.
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia. Albert, K., Niskanen, J., Kälvälä, S., & Lehtonen, Š. (2021). International Journal of Molecular Sciences, 22(9), 4334.
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids. Fagerlund, I., Dougalis, A., Shakirzyanova, A., Gómez-Budia, M., Pelkonen, A., Konttinen, H., Ohtonen, S., Fazaludeen, M. F., Koskuvi, M., Kuusisto, J., Hernández, D., Pebay, A., Koistinaho, J., Rauramaa, T., Lehtonen, Š., Korhonen, P., & Malm, T. (2021). Cells, 11(1), 124.
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo. Keuters, M. H., Keksa-Goldsteine, V., Dhungana, H., Huuskonen, M. T., Pomeshchik, Y., Savchenko, E., Korhonen, P. K., Singh, Y., Wojciechowski, S., Lehtonen, Š., Kanninen, K. M., Malm, T., Sirviö, J., Muona, A., Koistinaho, M., Goldsteins, G., & Koistinaho, J. (2021). Scientific Reports, 11(1), 3518.
Metabolic and immune dysfunction of glia in neurodegenerative disorders: Focus on iPSC models. Rõlova, T., Lehtonen, Š., Goldsteins, G., Kettunen, P., & Koistinaho, J. (2021). Stem Cells, 39(3), 256–265.
Studying non–cell-autonomous neurodegeneration in Parkinson’s disease with induced pluripotent stem cells. Sonninen, T.-M., Plotnikova, L., Laham-Karam, N., Goldsteins, G., Koistinaho, J., & Lehtonen, Š. (2021). In IPSCs for Modeling Central Nervous System Disorders (pp. 251–276). Elsevier.
Molecular signaling pathways underlying schizophrenia. Tiihonen, J., Koskuvi, M., Lähteenvuo, M., Trontti, K., Ojansuu, I., Vaurio, O., Cannon, T. D., Lönnqvist, J., Therman, S., Suvisaari, J., Cheng, L., Tanskanen, A., Taipale, H., Lehtonen, Š., & Koistinaho, J. (2021). Schizophrenia Research, 232, 33–41.
Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells. Wu, Y.-C., Sonninen, T.-M., Peltonen, S., Koistinaho, J., & Lehtonen, Š. (2021). International Journal of Molecular Sciences, 22(14), 7710.
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture. Grubman, A., Vandekolk, T. H., Schröder, J., Sun, G., Hatwell-Humble, J., Chan, J., Oksanen, M., Lehtonen, S., Hunt, C., Koistinaho, J. E., Nilsson, S. K., Haynes, J. M., Pouton, C. W., & Polo, J. M. (2020). Stem Cell Reports, 14(6), 1018–1032.
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery. Oikari, L. E., Pandit, R., Stewart, R., Cuní-López, C., Quek, H., Sutharsan, R., Rantanen, L. M., Oksanen, M., Lehtonen, S., De Boer, C. M., Polo, J. M., Götz, J., Koistinaho, J., & White, A. R. (2020). Stem Cell Reports, 14(5), 924–939.
NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer’s disease astrocytes. Oksanen, M., Hyötyläinen, I., Trontti, K., Rolova, T., Wojciechowski, S., Koskuvi, M., Viitanen, M., Levonen, A., Hovatta, I., Roybon, L., Lehtonen, Š., Kanninen, K. M., Hämäläinen, R. H., & Koistinaho, J. (2020). Glia, 68(3), 589–599.
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease. Rolova, T., Wu, Y.-C., Koskuvi, M., Voutilainen, J., Sonninen, T.-M., Kuusisto, J., Laakso, M., Hämäläinen, R. H., Koistinaho, J., & Lehtonen, Š. (2020). Stem Cell Research, 48, 101968.
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases. Sonninen, T.-M., Goldsteins, G., Laham-Karam, N., Koistinaho, J., & Lehtonen, Š. (2020). Cells, 9(10), 2183.
Metabolic alterations in Parkinson’s disease astrocytes. Sonninen, T.-M., Hämäläinen, R. H., Koskuvi, M., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, K., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J., & Lehtonen, Š. (2020). Scientific Reports, 10(1), 14474.
Neurobiological roots of psychopathy. Tiihonen, J., Koskuvi, M., Lähteenvuo, M., Virtanen, P. L. J., Ojansuu, I., Vaurio, O., Gao, Y., Hyötyläinen, I., Puttonen, K. A., Repo-Tiihonen, E., Paunio, T., Rautiainen, M.-R., Tyni, S., Koistinaho, J., & Lehtonen, Š. (2020). Molecular Psychiatry, 25(12), 3432–3441.
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Konttinen, H., Cabral-da-Silva, M. E. C., Ohtonen, S., Wojciechowski, S., Shakirzyanova, A., Caligola, S., Giugno, R., Ishchenko, Y., Hernández, D., Fazaludeen, M. F., Eamen, S., Budia, M. G., Fagerlund, I., Scoyni, F., Korhonen, P., Huber, N., Haapasalo, A., Hewitt, A. W., Vickers, J., … Malm, T. (2019). Stem Cell Reports, 13(4), 669–683.
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis. Korhonen, P., Pollari, E., Kanninen, K. M., Savchenko, E., Lehtonen, Š., Wojciechowski, S., Pomeshchik, Y., Van Den Bosch, L., Goldsteins, G., Koistinaho, J., & Malm, T. (2019). IBRO Reports, 6, 74–86.
Dysfunction of Cellular Proteostasis in Parkinson’s Disease. Lehtonen, Š., Sonninen, T.-M., Wojciechowski, S., Goldsteins, G., & Koistinaho, J. (2019). Frontiers in Neuroscience, 13, 457.
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms. Oksanen, M., Lehtonen, S., Jaronen, M., Goldsteins, G., Hämäläinen, R. H., & Koistinaho, J. (2019). Cellular and Molecular Life Sciences, 76(14), 2739–2760.
Sex-specific transcriptional and proteomic signatures in schizophrenia. Tiihonen, J., Koskuvi, M., Storvik, M., Hyötyläinen, I., Gao, Y., Puttonen, K. A., Giniatullina, R., Poguzhelskaya, E., Ojansuu, I., Vaurio, O., Cannon, T. D., Lönnqvist, J., Therman, S., Suvisaari, J., Kaprio, J., Cheng, L., Hill, A. F., Lähteenvuo, M., Tohka, J., … Koistinaho, J. (2019). Nature Communications, 10(1), 3933.
Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling. Koivumäki, J. T., Naumenko, N., Tuomainen, T., Takalo, J., Oksanen, M., Puttonen, K. A., Lehtonen, Š., Kuusisto, J., Laakso, M., Koistinaho, J., & Tavi, P. (2018). Frontiers in Physiology, 9, 80.
Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer’s disease. Lehtonen, Š., Höytyläinen, I., Voutilainen, J., Sonninen, T.-M., Kuusisto, J., Laakso, M., Hämäläinen, R. H., Oksanen, M., & Koistinaho, J. (2018). Stem Cell Research, 30, 96–99.
Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer’s disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene. Oksanen, M., Hyötyläinen, I., Voutilainen, J., Puttonen, K. A., Hämäläinen, R. H., Graff, C., Lehtonen, Š., & Koistinaho, J. (2018). Stem Cell Research, 31, 181–185.
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease. Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., Rinne, J. O., Hiltunen, M., Haapasalo, A., Giniatullin, R., Tavi, P., Zhang, S.-C., Kanninen, K. M., Hämäläinen, R. H., & Koistinaho, J. (2017). Stem Cell Reports, 9(6), 1885–1897.
Creation of a library of induced pluripotent stem cells from Parkinsonian patients. Holmqvist, S., Lehtonen, Š., Chumarina, M., Puttonen, K. A., Azevedo, C., Lebedeva, O., Ruponen, M., Oksanen, M., Djelloul, M., Collin, A., Goldwurm, S., Meyer, M., Lagarkova, M., Kiselev, S., Koistinaho, J., & Roybon, L. (2016). Npj Parkinson’s Disease, 2(1), 16009.
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP + Toxicity-Induced Parkinson’s Disease Models. Lehtonen, Š., Jaronen, M., Vehviläinen, P., Lakso, M., Rudgalvyte, M., Keksa-Goldsteine, V., Wong, G., Courtney, M. J., Koistinaho, J., & Goldsteins, G. (2016) Antioxidants & Redox Signaling, 25(8), 485–497.
Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases. Lehtonen, Š., Lehtonen, M., & Koistinaho, J. (2016). In M. Tomizawa (Ed.), Pluripotent Stem Cells—From the Bench to the Clinic. InTech.
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Lemarchant, S., Pomeshchik, Y., Kidin, I., Kärkkäinen, V., Valonen, P., Lehtonen, S., Goldsteins, G., Malm, T., Kanninen, K., & Koistinaho, J. (2016). Molecular Neurodegeneration, 11(1), 10.
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. Liddell, J. R., Lehtonen, S., Duncan, C., Keksa-Goldsteine, V., Levonen, A.-L., Goldsteins, G., Malm, T., White, A. R., Koistinaho, J., & Kanninen, K. M. (2016). Journal of Neuroinflammation, 13(1), 49.
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Korhonen, P., Kanninen, K. M., Lehtonen, Š., Lemarchant, S., Puttonen, K. A., Oksanen, M., Dhungana, H., Loppi, S., Pollari, E., Wojciechowski, S., Kidin, I., García-Berrocoso, T., Giralt, D., Montaner, J., Koistinaho, J., & Malm, T. (2015). Brain, Behavior, and Immunity, 49, 322–336.
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. Pomeshchik, Y., Kidin, I., Korhonen, P., Savchenko, E., Jaronen, M., Lehtonen, S., Wojciechowski, S., Kanninen, K., Koistinaho, J., & Malm, T. (2015). Brain, Behavior, and Immunity, 44, 68–81.
Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal Cord Injury. Pomeshchik, Y., Puttonen, K. A., Kidin, I., Ruponen, M., Lehtonen, S., Malm, T., Åkesson, E., Hovatta, O., & Koistinaho, J. (2015). Cell Transplantation, 24(9), 1799–1812.
Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aβ Toxicity. Kärkkäinen, V., Pomeshchik, Y., Savchenko, E., Dhungana, H., Kurronen, A., Lehtonen, S., Naumenko, N., Tavi, P., Levonen, A.-L., Yamamoto, M., Malm, T., Magga, J., Kanninen, K. M., & Koistinaho, J. (2014). Stem Cells, 32(7), 1904–1916.
Tyrosine hydroxylase gene transfections to different sites of striatum in the rat model of Parkinson’s disease. Raasmaja, A., Lehtonen, S., Kääriäinen, T., Lampela, P., Huotari, M., & Lecklin, A. (2013). Open Journal of Genetics, 03(02), 30–37.
Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells. Huuskonen, P., Storvik, M., Kyllönen, T., Lehtonen, S., El-Nezami, H., Auriola, S., & Pasanen, M. (2012). Toxicology Letters, 211, S186.
Production of monocytic cells from bone marrow stem cells: Therapeutic usage in Alzheimer’s disease. Magga, J., Savchenko, E., Malm, T., Rolova, T., Pollari, E., Valonen, P., Lehtonen, Š., Jantunen, E., Aarnio, J., Lehenkari, P., Koistinaho, M., Muona, A., & Koistinaho, J. (2012). Journal of Cellular and Molecular Medicine, 16(5), 1060–1073.
Aflatoxin B1 – a potential endocrine disruptor – up-regulates CYP19A1 in JEG-3 cells. Storvik, M., Huuskonen, P., Kyllönen, T., Lehtonen, S., El-Nezami, H., Auriola, S., & Pasanen, M. (2011). Toxicology Letters, 202(3), 161–167.