PUBLICATIONS

SELECTED PUBLICATIONS

  1. StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling. Giudice L, Mohamed A, Malm T.PLoS Comput Biol. 2024 Apr 12;20(4):e1012022. doi: 10.1371/journal.pcbi.1012022. eCollection 2024 Apr.PMID: 38607982 Free PMC article.
  2. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling. Scoyni F, Sitnikova V, Giudice L, Korhonen P, Trevisan DM, Hernandez de Sande A, Gomez-Budia M, Giniatullina R, Ugidos IF, Dhungana H, Pistono C, Korvenlaita N, Välimäki NN, Kangas SM, Hiltunen AE, Gribchenko E, Kaikkonen-Määttä MU, Koistinaho J, Ylä-Herttuala S, Hinttala R, Venø MT, Su J, Stoffel M, Schaefer A, Rajewsky N, Kjems J, LaPierre MP, Piwecka M, Jolkkonen J, Giniatullin R, Hansen TB, Malm T.Cell Rep. 2024 Mar 26;43(3):113862. doi: 10.1016/j.celrep.2024.113862. Epub 2024 Mar 5.PMID: 38446664 Free article.
  3. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs. Scoyni F, Giudice L, Väänänen MA, Downes N, Korhonen P, Choo XY, Välimäki NN, Mäkinen P, Korvenlaita N, Rozemuller AJ, de Vries HE, Polo J, Turunen TA, Ylä-Herttuala S, Hansen TB, Grubman A, Kaikkonen MU, Malm T.Alzheimers Dement. 2024 Feb;20(2):954-974. doi: 10.1002/alz.13502. Epub 2023 Oct 12.PMID: 37828821 Free PMC article.
  4. Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function. Ohtonen S, Giudice L, Jäntti H, Fazaludeen MF, Shakirzyanova A, Gómez-Budia M, Välimäki NN, Niskanen J, Korvenlaita N, Fagerlund I, Koistinaho J, Amiry-Moghaddam M, Savchenko E, Roybon L, Lehtonen Š, Korhonen P, Malm T.Sci Rep. 2023 Dec 13;13(1):22118. doi: 10.1038/s41598-023-49294-9.PMID: 38092815 Free PMC article.
  5. Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia. Korvenlaita N, Gómez-Budia M, Scoyni F, Pistono C, Giudice L, Eamen S, Loppi S, de Sande AH, Huremagic B, Bouvy-Liivrand M, Heinäniemi M, Kaikkonen MU, Cheng L, Hill AF, Kanninen KM, Jenster GW, van Royen ME, Ramiro L, Montaner J, Batkova T, Mikulik R, Giugno R, Jolkkonen J, Korhonen P, Malm T.J Extracell Vesicles. 2023 Jan;12(1):e12297. doi: 10.1002/jev2.12297.PMID: 36594832 Free PMC article.
  6. Microglial amyloid beta clearance is driven by PIEZO1 channels. Jäntti H, Sitnikova V, Ishchenko Y, Shakirzyanova A, Giudice L, Ugidos IF, Gómez-Budia M, Korvenlaita N, Ohtonen S, Belaya I, Fazaludeen F, Mikhailov N, Gotkiewicz M, Ketola K, Lehtonen Š, Koistinaho J, Kanninen KM, Hernández D, Pébay A, Giugno R, Korhonen P, Giniatullin R, Malm T.J Neuroinflammation. 2022 Jun 15;19(1):147. doi: 10.1186/s12974-022-02486-y.PMID: 35706029 Free PMC article.
  7. Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan. Ugidos IF, Pistono C, Korhonen P, Gómez-Budia M, Sitnikova V, Klecki P, Stanová I, Jolkkonen J, Malm T. 2022 May;53(5):1500-1509. doi: 10.1161/STROKEAHA.122.039138. Epub 2022 Apr 25.PMID: 35468000 Review.
  8. Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids. Fagerlund I, Dougalis A, Shakirzyanova A, Gómez-Budia M, Pelkonen A, Konttinen H, Ohtonen S, Fazaludeen MF, Koskuvi M, Kuusisto J, Hernández D, Pebay A, Koistinaho J, Rauramaa T, Lehtonen Š, Korhonen P, Malm T. 2021 Dec 30;11(1):124. doi: 10.3390/cells11010124.PMID: 35011686 Free PMC article.
  9. Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays. Pelkonen A, Pistono C, Klecki P, Gómez-Budia M, Dougalis A, Konttinen H, Stanová I, Fagerlund I, Leinonen V, Korhonen P, Malm T. 2021 Dec 29;11(1):106. doi: 10.3390/cells11010106.PMID: 35011667 Free PMC article.Review.
  10. Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease. Pistono C, Bister N, Stanová I, Malm T.Front Cell Dev Biol. 2021 Jan 25;8:623771. doi: 10.3389/fcell.2020.623771. eCollection 2020.PMID: 33569385 Free PMC article.
  11. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals. Loppi S, Korhonen P, Bouvy-Liivrand M, Caligola S, Turunen TA, Turunen MP, Hernandez de Sande A, Kołosowska N, Scoyni F, Rosell A, García-Berrocoso T, Lemarchant S, Dhungana H, Montaner J, Koistinaho J, Kanninen KM, Kaikkonen MU, Giugno R, Heinäniemi M, Malm T.Aging Cell. 2021 Jan;20(1):e13287. doi: 10.1111/acel.13287. Epub 2020 Dec 28.PMID: 33369048 Free PMC article.
  12. Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions. Bister N, Pistono C, Huremagic B, Jolkkonen J, Giugno R, Malm T.J Extracell Vesicles. 2020 Oct;10(1):e12002. doi: 10.1002/jev2.12002. Epub 2020 Nov 14.PMID: 33304471 Free PMC article.
  13. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation. Kolosowska N, Gotkiewicz M, Dhungana H, Giudice L, Giugno R, Box D, Huuskonen MT, Korhonen P, Scoyni F, Kanninen KM, Ylä-Herttuala S, Turunen TA, Turunen MP, Koistinaho J, Malm T.J Neuroinflammation. 2020 Jun 19;17(1):194. doi: 10.1186/s12974-020-01870-w.PMID: 32560730 Free PMC article.
  14. Glial smog: Interplay between air pollution and astrocyte-microglia interactions. Gómez-Budia M, Konttinen H, Saveleva L, Korhonen P, Jalava PI, Kanninen KM, Malm T.Neurochem Int. 2020 Jun;136:104715. doi: 10.1016/j.neuint.2020.104715. Epub 2020 Mar 10.PMID: 32169588 Free article.
  15. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T.Stem Cell Reports. 2019 Oct 8;13(4):669-683. doi: 10.1016/j.stemcr.2019.08.004. Epub 2019 Sep 12.PMID: 31522977 Free PMC article.
  16. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice. Singh Y, Leinonen H, Fazaludeen F, Jaronen M, Guest D, Buckley N, Byts N, Oksa P, Jalkanen K, Iqbal I, Huuskonen M, Savchenko E, Keksa-Goldsteine V, Chew S, Myllyharju J, Tanila H, Ooi L, Koistinaho J, Kanninen KM, Malm T.Hum Mol Genet. 2019 Oct 1;28(19):3309-3322. doi: 10.1093/hmg/ddz165.PMID: 31294445
  17. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis. Korhonen P, Pollari E, Kanninen KM, Savchenko E, Lehtonen Š, Wojciechowski S, Pomeshchik Y, Van Den Bosch L, Goldsteins G, Koistinaho J, Malm T.IBRO Rep. 2019 Jan 11;6:74-86. doi: 10.1016/j.ibror.2019.01.005. eCollection 2019 Jun.PMID: 30705990 Free PMC article.
  18. PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes. Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19.PMID: 30453390 Free PMC article.
  19. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T.J Neuroinflammation. 2017 Dec 4;14(1):237. doi: 10.1186/s12974-017-1010-7.PMID: 29202856 Free PMC article.
  20. Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets. Grubman A, Kanninen KM, Malm T.J Mol Neurosci. 2016 Nov;60(3):390-404. doi: 10.1007/s12031-016-0825-5. Epub 2016 Sep 22.PMID: 27660215 Review.
  21. Exosomes as new diagnostic tools in CNS diseases. Kanninen KM, Bister N, Koistinaho J, Malm T.Biochim Biophys Acta. 2016 Mar;1862(3):403-10. doi: 10.1016/j.bbadis.2015.09.020. Epub 2015 Oct 20.PMID: 26432482 Free article.No abstract available.
  22. Exosomes in cerebral diseases – novel form of intercellular communication. Kanninen K, Malm T. 2016;132(21):1957-63.PMID: 29190047 Review.
  23. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T.Brain Behav Immun. 2015 Oct;49:322-36. doi: 10.1016/j.bbi.2015.06.013. Epub 2015 Jun 22.PMID: 26111431
  24. Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T.Brain Behav Immun. 2015 Feb;44:68-81. doi: 10.1016/j.bbi.2014.08.002. Epub 2014 Aug 18.PMID: 25153903
  25. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T.Neurobiol Dis. 2014 Apr;64:16-29. doi: 10.1016/j.nbd.2013.12.003. Epub 2013 Dec 15.PMID: 24345324
  26. Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T.J Neuroinflammation. 2013 Aug 20;10:102. doi: 10.1186/1742-2094-10-102.PMID: 23957944 Free PMC article.
  27. Brain environment and Alzheimer’s disease mutations affect the survival, migration and differentiation of neural progenitor cells. Karkkainen V, Magga J, Koistinaho J, Malm T.Curr Alzheimer Res. 2012 Nov;9(9):1030-42. doi: 10.2174/156720512803569028.PMID: 22950909
  28. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer’s Disease: Involvement of the Nrf2-ARE Pathway. Kanninen K, White AR, Koistinaho J, Malm T.Int J Alzheimers Dis. 2011;2011:985085. doi: 10.4061/2011/985085. Epub 2011 May 2.PMID: 21629716 Free PMC article.