PUBLICATIONS

SELECTED PUBLICATIONS

1. Konttinen, e Castro Cabral-da-Silva, Ohtonen S, Wojciechowski S, Shakirzyanova S, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen F, Eamen S, Gómez Budia M, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, W. Hewitt A, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay S, Koistinaho J, Ooi L, Malm T. PSEN1ΔE9, APPswe and APOE4 confer disparate phenotypes in human iPSC-derived microglia. Stem Cell Reports 2019, Oct 8;13(4):669-683. DOI: https://doi.org/10.1016/j.stemcr.2019.08.004.

2. Singh Y, Leinonen H, Fazaludeen F, Jaronen, M, Debbie G, Buckley N, Byts N, Oksa P, Jalkanen K, Iqbal I, Huuskonen M, Savchenko E, Keksa-Goldsteine V, Chew S, Myllyharju J, Tanila H, Ooi L, Koistinaho J, Kanninen K and Malm T. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice. Human Molecular Genetics. 2019, Jul 11, pii: ddz165. DOI: https://doi.org/10.1093/hmg/ddz165.

3. Turunen T, Roberts T, Laitinen P, Väänänen M-A, Korhonen P, Malm T, Ylä-Herttuala S, and Turunen M. Changes in nuclear and cytoplasmic microRNA distribution following hypoxic stress”. Scientific Reports 2019, Jul 17;9(1):10332. DOI: https://doi.org/10.1038/s41598-019-46841-1.

4. Ezzat K, Pernemalm M, Pålsson S, Roberts TC, Järver P, Dondalska A, Bestas B, Sobkowiak MJ, Levänen B, Sköld M, Thompson EA, Kari OK, Lajunen T, Ishchenko Y, Malm T, Wood MJA, Power UF, Masich S, Lindén A, Sandberg JK, Lehtiö J, Spetz AL, EL Andaloussi S. The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation. Nature Communications 2019, May 27;10(1):2331. DOI: https://doi.org/10.1038/s41467-019-10192-2.

5. Konttinen H, Gureviciene I*, Oksanen M*, Grubman A, Loppi, Huuskonen MT, Korhonen P, Lampinen T, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T. PPARβ/δ-agonist GW0742 Ameliorates Dysfunction in Fatty Acid Oxidation in PSEN1ΔE9 Astrocytes. Glia 2019, Jan;67(1):146-159. DOI: https://doi.org/10.1002/glia.23534.

6. Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain Behav Immun 2018 Oct; 73:670-681. DOI: https://doi.org/10.1016/j.bbi.2018.07.021

7. Dhungana H, Huuskonen M, Jaronen M, Lemarchant S, Ali S, Keksa-Goldsteine V Goldsteins G, Kanninen K, Koistinaho J, Malm T. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke induced neuroinflammation. J Neuroinflammation, 2017, Dec 4;14(1)237. DOI: https://doi.org/10.1186/s12974-017-1010-7.

8. Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T (2015). Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Brain Behav Immun. 2015 Jun 22. doi: 10.1016/j.bbi.2015.06.013. DOI: https://doi.org/10.1016/j.bbi.2015.06.013.

9. Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury. Cell Transplant 2015;24(9):1799-812. DOI: https://doi.org/10.3727/096368914X684079.

10. Malm T, Mariani M, Donovan LJ, Neilson L, Landreth GE. Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation. J Neuroinflammation 2015. Jan 16;12:7. DOI: https://doi.org/10.1186/s12974-014-0229-9.